Clinical trials: Diabetes Type I
Type 1 Diabetes Mellitus
Fr1da Early Diagnosis and Care of Type 1 Diabetes
The Fr1da study: "Early diagnosis and care of type 1 diabetes" aims to carry out a comprehensive, population-based screening for the early diagnosis of type 1 diabetes as part of the U7 to U11 preventive medical check-up for…
- Trial name
- Fr1da (NCT04039945)
- Where
- Germany
- Volunteers
- 285,000 people, healthy volunteers welcome
- Sponsor
- Helmholtz Zentrum München
Diabetes, Hypoglycemia
Phase 1 Study of BHT-3021 in Subjects With Type 1 Diabetes Mellitus
The purpose of this study is to determine the safety of BHT-3021 injections given weekly for 12 weeks and to evaluate the effect of BHT-3021 on antibody and immune (T cell) responses to autoantigens (e.g. insulin).
- Trial name
- NCT00453375
- Testing
- BHT-3021
- Where
- 18 sites in United States, Australia and 1 more
- Volunteers
- 80 people
- Sponsor
- Bayhill Therapeutics
Diabetes Mellitus, Type 1
A Study to Test How Insulin NNC0471-0119 H Works in the Body in Participants With Type 1 Diabetes When Given by an Insulin Pump
The study is looking at the effect and safety of a new fast-acting insulin (NNC0471 0119) to people with type 1 diabetes when given by an insulin pump.
- Trial name
- NCT06809621
- Testing
- NNC0471-0119 H, Insulin aspart
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 1
Comparison of Two Pen Systems in Patients With Diabetes Treated With Insulin
This trial is conducted in Europe. The aim of this trial is to compare two insulin delivery pens in the everyday life setting of patients with diabetes treated with insulin.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT00569998
- Testing
- NovoPen™ 4, NovoPen® 3
- Where
- 23 sites in Austria, Germany and 3 more
- Volunteers
- 208 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
A Research Study Looking at How Faster Aspart Injected in Double Concentration Works in the Body of People With Type 1 Diabetes Mellitus
This study is looking at how five different formulations of faster aspart 200 U/mL reach and stay in the blood after injection. The purpose is to find a formulation that behaves similarly to the reference product called faster…
- Trial name
- NCT03723759
- Testing
- Faster Aspart 200 U/mL, Faster aspart 100 U/mL
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
ACCU-CHEK® Aviva Expert Study: Does Use of a Bolus Advisor Improve Glycemic Control in Patients Not Achieving Optimal Control Using Multiple Daily Injections (MDI)?
This clinical, prospective, randomized, multi-center study determined if the use of an insulin bolus advisor improves glycemic control as measured by a change in HbA1c in patients failing multiple daily injection/intensified…
- Trial name
- ABACUS (NCT01460446)
- Testing
- Aviva Expert blood glucose meter, Aviva Nano blood glucose meter
- Where
- 33 sites in Germany, United Kingdom
- Volunteers
- 218 people
- Sponsor
- Hoffmann-La Roche
Type 1 Diabetes Mellitus
To Investigate the Efficacy and Safety of Individualized Doses of BioChaperone Insulin Lispro in Comparison to Humalog® U-100 in Patients With Type 1 Diabetes Mellitus
This is a double-blind, randomised, controlled, two period crossover phase Ib trial using an individualized standard meal with a fixed nutrient ratio in subjects with type 1 diabetes mellitus to investigate postprandial blood…
- Trial name
- NCT02528396
- Testing
- BioChaperone insulin lispro, Humalog®
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Adocia
Type 1 Diabetes Mellitus
A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus
The main purpose of this study is to evaluate the effect of excipients sodium citrate and treprostinil without insulin on local infusion site pain in participants with type 1 diabetes mellitus (T1DM) on continuous subcutaneous…
- Trial name
- NCT05067270
- Testing
- Sodium Citrate, Treprostinil, Humalog diluent
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
Feasibility Study Assessing The Ability Of An Insulin Pump-Controlling Algorithm To Minimize Hypoglycemia And Hyperglycemia In Patients With Type 1 Diabetes In A Clinical Research Setting
The purpose of this study is to evaluate the performance of an insulin pump controlling algorithm while the subject is under close medical supervision in the Clinical Research Center (CRC) setting.
- Trial name
- NCT01401751
- Testing
- Hypoglycemia-Hyperglycemia Minimizer System
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Animas Corporation
Diabetic Foot
Phase 2b Study of GAM501 in the Treatment of Diabetic Ulcers of the Lower Extremities
This is a Phase 2b, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of one or two applications of topically applied GAM501 (Ad5PDGF-B/Bovine Type I Collagen Gel) in subjects ≥ 18 years old…
- Trial name
- MATRIX (NCT00493051)
- Testing
- GAM501, Standard of care
- Where
- 29 sites in United States
- Volunteers
- 124 people
- Sponsor
- Tissue Repair Company
Type 1 Diabetes Mellitus
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK-1293 Compared With a Basal Insulin in Participants With Type 1 Diabetes (MK-1293-005)
The purpose of this study is to assess the safety, pharmacokinetics, and pharmacodynamics of MK-1293 compared with a basal insulin (EU-Lantus™) in participants with Type 1 Diabetes.
- Trial name
- NCT02059174
- Testing
- MK-1293, EU-Lantus™, Novolog™
- Volunteers
- 76 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Type 1
The MIND Study - Microangiopathy IN Diabetes
This clinical investigation will evaluate two contactless optical devices based on spatial frequency domain and laser speckle technology for quantification of the skin micro-circulation in patients with diabetes mellitus type 1.
- Trial name
- NCT06989190
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Diabetes, Diabetes Mellitus, Type 1
Observational Study With InnoLet® in Daily Clinical Practice
This study is conducted in Asia. The aim of this study is to review the efficacy and safety of insulin treatment with InnoLet® in daily clinical practice.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01492959
- Testing
- insulin human
- Where
- South Korea
- Volunteers
- 1,030 people
- Sponsor
- Novo Nordisk A/S
Diabetes
Comparative Glucose Clamp Study of Wockhardt's Insulin Human Regular for Injection and Actrapid, in Type 1 Diabetics
The aim of this trial is to demonstrate bioequivalence of Wosulin R to Actrapid with regard to its total and to its maximum serum insulin concentrations.
- Trial name
- NCT00752180
- Testing
- Wosulin R, Actrapid
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Wockhardt
Identification of Infants at Risk for Type 1 Diabetes
Freder1k-Study - Testing Infants for Type 1 Diabetes Risk
The Freder1k-Study will identify infants who have a high genetic risk of type 1 diabetes.
- Trial name
- NCT03316261
- Where
- Germany
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Helmholtz Zentrum München
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Efficacy and Safety of Insulin Degludec in Children and Adolescents With Type 1 Diabetes Mellitus
This trial is conducted in Africa, Asia, Europe and the United States of America (USA). The aim of this trial is to investigate the efficacy and safety of insulin degludec in children and adolescents with type 1 diabetes mellitus.
- Trial name
- BEGIN™ (NCT01513473)
- Testing
- insulin degludec, insulin detemir, insulin aspart
- Where
- 81 sites in United States, Bulgaria and 10 more
- Volunteers
- 350 people
- Sponsor
- Novo Nordisk A/S
Overweight, Obese
A Study of CT-868 in Type 1 Diabetes Mellitus
This study will evaluate the changes in glycemic control in overweight and obese adults with Type 1 Diabetes Mellitus after receiving CT-868 for 16 weeks. The effectiveness and safety of CT-868 will be compared to placebo.
- Conditions
- Overweight, Obese, Type 1 Diabetes Mellitus
- Trial name
- NCT06062069
- Testing
- CT-868, CT-868 Pen Injector
- Where
- 22 sites in United States
- Volunteers
- 111 people
- Sponsor
- Carmot Therapeutics, Inc.
Clamp Study
A Study to Compare Pharmacokinetics and Pharmacodynamics of RinGlar® to Lantus® in Type 1 Diabetes Mellitus Patients
Pharmacokinetics and pharmacodynamics study of 2 formulation of insulin glargine (RinGlar® GEROPHARM vers. Lantus® Sanofi-Aventis)
- Trial name
- NCT04101383
- Testing
- RinGlar®, Lantus®
- Where
- 2 sites in Russia
- Volunteers
- 42 people
- Sponsor
- Geropharm
Diabetes Mellitus, Type 1
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
This study compares insulin icodec, an insulin taken once a week to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 1 diabetes.
- Trial name
- ONWARDS 11 (NCT07076199)
- Testing
- Insulin icodec, Insulin glargine, Insulin aspart
- Where
- 182 sites in United States, Australia and 6 more
- Volunteers
- 877 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Neuropeptide Therapy of Recent Onset Type 1 Diabetes
This study evaluates the delivery of substance P via the celiac artery in the treatment of recent onset type 1 diabetes.
- Trial name
- NCT02820558
- Testing
- Substance P
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Vanilloid Genetics Inc.
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