Clinical trials: Diabetes in Children
Type 1 Diabetes Mellitus, Glycemic Control
Effect of Immediate Hemoglobin A1c on Glycemic Control in Children With Type I Diabetes Mellitus
Immediate feedback of hemoglobin A1c (A1c) results to adults with type 1 and 2 diabetes allows more appropriate care decisions at the clinic visit and may improve glycemic control.
- Trial name
- NCT00898534
- Testing
- Bayer DCA2000+ Hemoglobin A1c analyzer
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes
Impact of a Diabetes Camp on Glycemic Control Among Children and Adolescents Living With Type 1 Diabetes in Cameroon
Therapeutic education is central to the management of diabetes, especially in children and adolescents. Camps represent an ideal environment for education.
- Trial name
- NCT02632032
- Testing
- Insulin
- Volunteers
- 46 people
- Sponsor
- Yaounde Central Hospital
Type 1 Diabetes
Safety Evaluation of MiniMed™ 780G System With DS5 CGM in Children
The purpose of this study is to evaluate the safety of the MiniMed 780G insulin pump used in combination with the DS5 CGM in type 1 pediatric subjects (2-6 years of age) in a home setting.
- Trial name
- SUCCEED2 (NCT06604871)
- Testing
- Insulin Pump with Continuous Glucose Monitoring
- Where
- 8 sites in United States
- Volunteers
- 56 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
Dose Finding Study of Il-2 at Ultra-low Dose in Children With Recently Diagnosed Type 1 Diabetes
Human recombinant interleukin-2 (rhIL-2) is a biological signalling protein playing a key role in the regulation of the immune system.
- Trial name
- DFIL2-Child (NCT01862120)
- Testing
- Dose D1 of interleukin-2, Dose D2 of Interleukin-2, Dose D3 of interleukin-2
- Where
- 6 sites in France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes Mellitus
Preschool CGM Use and Glucose Variability in Type 1 Diabetes
The objectives of this clinical study is to evaluate the efficacy continuous glucose monitoring (CGM) use on glucose variability (GV) in preschool children with T1D treated with CSII.
- Trial name
- NCT03293082
- Testing
- CGM ON, CGM OFF
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Type 1 Diabetes Mellitus
Comparing the Metabolic Control of Once to Twice-daily Insulin Detemir Injections
An open-label, treat to target, intervention study in order to compare the metabolic control of once to twice-daily insulin Detemir injections in children and adolescence with type 1 diabetes mellitus.
- Trial name
- NCT00542399
- Testing
- Levemir (insulin detemir), Levemir twice a day
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
Effect of Fiber Supplementation in Children With Type 1 Diabetes
High fiber foods are recommended as a preferential source of carbohydrate by the Nutrition Study Group of the European Association for the Study of Diabetes.
- Trial name
- NCT01399892
- Testing
- soluble fiber in the form of benefiber
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
The Role of Amylin and Glucagon in T1DM
The purpose of this study is to see if giving pramlintide and insulin before a meal would lower high blood sugar and if a glucagon (a naturally made hormone in the body but reduced in diabetes and its role is in prevention of low…
- Trial name
- NCT00206258
- Testing
- Pramlintide and glucagon
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hyperinsulinism, Diabetes
Bionic Pancreas in Children With Hyperinsulinism and Post-Pancreatectomy Diabetes
This is a pilot study designed to determine if the bihormonal bionic pancreas provides improved blood glucose control, compared to the current standard of care, in individuals with hyperinsulinism who developed diabetes after…
- Conditions
- Hyperinsulinism, Diabetes, Pancreatic Diseases, Pancreatectomy; Hyperglycemia
- Trial name
- NCT03303196
- Testing
- Bihormonal Bionic Pancreas
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Type I Diabetes
Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes
This is a randomized, double-blind, placebo-controlled phase 2 study. Specific aim is to evaluate feasibility and safety of anti-IL-1 (interleukin 1) treatment in the course of standard therapy for diabetic ketoacidosis in…
- Trial name
- NCT01477476
- Testing
- Anakinra
- Where
- 2 sites in United States
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- PSO4 (NCT01823341)
- Testing
- Pump suspension algorithm
- Where
- 3 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus
Sports Participation in Children and Adolescents With Type 1 Diabetes Mellitus
On the basis of a questionnaire the participation at sports activities of children and adolescents with type 1 diabetes mellitus will be studied.
- Trial name
- NCT03291834
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Jessa Hospital
Type 1 Diabetes
Use of Control-IQ Technology 2.0 in Adults, Children, and Preschoolers With Type 1 Diabetes
The goal of this clinical trial is to assess safety of and explore glycemic outcomes with Control-IQ technology 2.0 in adults, children and preschoolers with type 1 diabetes.
- Trial name
- NCT05683392
- Testing
- t:slim X2 insulin pump with Control-IQ technology 2.0
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- Tandem Diabetes Care, Inc.
Overweight/Obesity
Reducing Diabetes Risk Factors in American Indian Children: Tribal Turning Point
This study will evaluate a behavioral intervention designed to reduce risk factors for type 2 diabetes in American Indian youth aged 7-10 years.
- Trial name
- TTP (NCT03573856)
- Testing
- Active Living, Health and Safety
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Cognitive-Behavioral Therapy (CBT) in Children With Diabetes
Diabetes mellitus in children and adolescents is a source of stress and poor quality of life for themselves and their family. Development of adaptive coping strategies may be improved by focused parent and children training.
- Trial name
- DI-CO (NCT02839031)
- Testing
- "CBT" (Cognitive-Behavioral Therapy), Control (telephonic support without CBT content)
- Where
- France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus
The Role of FTO Gene Polymorphism and Insulin Preparation in Obesity in Children With Type 1 Diabetes Mellitus
The project aims at assessment of the effect of the FTO gene polymorphism and the type of treatment on the development of overweight/obesity and features of metabolic syndrome in children with type 1 diabetes.
- Trial name
- FTO_T1DM (NCT01279161)
- Where
- 6 sites in Poland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
Insulin Requiring Diabetes
CEP249 Pediatric Accuracy Study
The purpose of this study is to evaluate the Enlite Sensor™ and Enlite 3 Sensor performance in pediatric patients with insulin requiring diabetes at the beginning, middle and end of sensor wear.
- Trial name
- NCT01991470
- Testing
- Enlite sensors
- Where
- 11 sites in United States
- Volunteers
- 186 people
- Sponsor
- Medtronic MiniMed, Inc.
Type1diabetes
Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children
To investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of…
- Trial name
- MAIT-DT1 (NCT05054361)
- Testing
- MAIT cells analysis, MAIT cytokines production analysis, Lactulose/Mannitol Test
- Where
- 2 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Gestatiaonl Diabetes Mellitus, Insulin Resistance
Impact of Gestational Diabetes on Childhood Obesity
In this study, we aimed to investigate the relationship between obesity, glucose intolerance (insulin resistance), dyslipidemia and diabetes in children aged 5-12 born to mothers with Gestational Diabetes Mellitus (GDM) in…
- Conditions
- Gestatiaonl Diabetes Mellitus, Insulin Resistance, Dyslipaemia, Obesity &Amp; Overweight
- Trial name
- NCT07069296
- Testing
- blood samples were collected from participants, blood samples
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Diabetes (Insulin-requiring, Type 1 or Type 2), Skin Abnormalities
Study on Influencing Factors of Skin Complications Related to Insulin Injection in Children With Type 1 Diabetes Mellitus
This study was a cross-sectional, observational design without involving random grouping or intervention. From July 2026 to June 2027, 199 children with type 1 diabetes who had received insulin treatment for at least 6 months and…
- Trial name
- NCT07615803
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine