Clinical trials: Diabetic Macular Edema
Diabetic Retinopathy
Squalamine Lactate Eye Drops in Combination With Ranibizumab in Patients With Diabetic Macular Edema (DME)
A randomized, controlled study of the safety and efficacy of Squalamine Lactate Eye Drops in combination with Ranibizumab intravitreal injections in patients with diabetic macular edema.
- Trial name
- NCT02349516
- Testing
- Squalamine Lactate Ophthalmic Solution 0.2%
- Where
- United States
- Sponsor
- Starr Muscle
Diabetic Macular Edema
Diabetic Retinopathy Assessed by Ultra-wide
Patients with diabetic macular edema treated with aflibercept injections for visual impairment will be observed in standard care during 12 months.
- Trial name
- REGARD1 (NCT03157206)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Association Pour La Recherche En Vision Du Service D'Ophtalmologie De L'Hôpital
Diabetic Macular Oedema
Near Infrared Photobiomodulation Treatment for Diabetic Macular Oedema
This pilot study aims to establish that treatment with near infrared light (NIR) reduces diabetic macular oedema in patients suffering diabetic retinopathy by exerting a positive beneficial effect at retinal cellular level.
- Trial name
- NIRD (NCT02181400)
- Testing
- Ellex Integre NIR laser
- Where
- Australia
- Volunteers
- 21 people
- Sponsor
- University of Sydney
Diabetic Retinopathy, DR
Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With and Without Diabetic Retinopathy
This is a prospective study designed to evaluate the long-term safety and efficacy of ABBV-RGX-314. Eligible participants are those who were previously enrolled in a clinical study of DR with and without center involved-diabetic…
- Trial name
- NCT05296447
- Testing
- Standard of Care, Aflibercept
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- AbbVie
Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration
Effectiveness of Multidisciplinary Protocolised Interventions on IVT Non-adherence Rates
The purpose of this research study is to test whether a personalised care approach improves adherence compared to standard care.
- Conditions
- Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration, Intravitreal Injection
- Trial name
- ADHERE (NCT07567898)
- Testing
- multidisciplinary protocolized intervention (MPI), Routine medical care & monitoring
- Volunteers
- 200 people
- Sponsor
- Singapore Eye Research Institute
Diabetic Macular Oedema
Aflibercept anD navigateD vErsus coNvensional Laser in Diabetic macUlar edeMa
Diabetic macular edema (DME) in diabetic retinopathy (DR) is the leading cause of visual impairment among the 300,000 Danish patients with diabetes (DM) and will in time affect 29% of patients.
- Trial name
- ADDENDUM (NCT02554747)
- Testing
- Navigated laser, Conventional laser
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Diabetic Macular Edema
A Pharmacokinetic stuDy of intRavitreal Aflibercept Injection in Vitrectomized and Non-vitrectomized Eyes With Diabetic Macular Edema
The primary objective is to investigate and characterize the intraocular pharmacokinetics (free and bound) following intravitreal aflibercept injection (IAI) in vitrectomized and non-vitrectomized eyes with diabetic macular edema…
- Trial name
- DRAW-2 (NCT04588948)
- Testing
- Intravitreal Aflibercept
- Where
- United States
- Sponsor
- Stanford University
Diabetic Macular Edema
The Effect of Bevacizumab and Ziv-aflibercept in Diabetic Macular Edema
In this double clinical trial 132 patient with the history of DME (Diabetic Macular Edema) to receive intravitreous bevacizumab at a dose of 1.25mg (44 patient) , ziv-aflibercept at dose of 1.25 mg (44 patient) , ziv-aflibercept…
- Trial name
- NCT02645734
- Testing
- bevacizumab, ziv-aflibercept 1.25 mg, ziv-aflibercept 2.5mg
- Where
- Iran
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Osteoporosis, Diabetes Mellitus
A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers
Diabetes mellitus is a common disease with much impact on human's health and is related to osteoporosis. But the mechanism remains unclear.
- Trial name
- NCT02429232
- Testing
- Pioglitazone, Linagliptin
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Diabetic Macular Edema
Treatment of Diabetic Macular Edema With Aflibercept and Micropulse Laser
The goal of this pilot study is to investigate the safety and efficacy of micropulse (MP) macular laser in combination with intravitreal aflibercept for the treatment of centre-involved diabetic macular edema.
- Trial name
- DAM (NCT03143192)
- Testing
- Micropulse Laser
- Where
- 2 sites in Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Keyvan Koushan
Diabetic Macular Edema
Assessment of Biomarker Profile in Diabetic Macular Edema With Intravitreal Aflibercept Injection
To assess the biomarker profile in diabetic macular edema patients in response to intravitreal aflibercept injection. Patients with diabetic macular edema who meet study requirements will receive monthly intravitreal injections…
- Trial name
- NCT03297684
- Testing
- Aflibercept Injection [Eylea]
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Advanced Eye Research Associates
Central Retinal Vein Occlusion With Macular Edema
Use of Ziv Aflibercept in Different Retinal Diseases
A prospective interventional case series study was conducted on 20 eyes of 20 patients with active myopic choroidal neovascularisation (CNV) ,20 eyes with resistant diabetic macular edema and 15 eyes with non ischaemic central…
- Trial name
- NCT04290195
- Testing
- Ziv-Aflibercept 25 MG/ML [Zaltrap]
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Amin El Sayed Nawar
Diabetic Retinopathy
The Effect of Intravitral Injection of Triamcinolone Combined With Cataract Surgery (Phacoemulsification) on Diabetic Macular Edema and Diabetic Retinopathy
In this study, regressed proliferative diabetic retinopathy, very severe, severe and moderate non-prolifrative diabetic retinopathy patients who were going to have a cataract surgery, underwent a complete eye examination, OCT…
- Trial name
- NCT00849537
- Testing
- Triamcinolone
- Where
- 3 sites in Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Diabetes Mellitus, Macular Edema
Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema
A Single Arm, Single Dose Study to Evaluate the Effect of intravitreal dexamethasone implant (Ozurdex®) on hard exudates of diabetic macular edema.
- Conditions
- Diabetes Mellitus, Macular Edema, Retinal Exudates and Deposits
- Trial name
- NCT02399657
- Testing
- Intravitreal dexamethasone 0.7mg implant
- Where
- 8 sites in South Korea
- Volunteers
- 48 people
- Sponsor
- Inje University
Diabetic Macular Oedema
To Evaluate the Comparative Efficacy of Lucentis (Ranibizumab) 0.5mg Intravitreal Injection in Patients With Diabetic Macular Oedema (DME) With Well Controlled and Poorly Controlled Diabetes Mellitus
To demonstrate the comparative effectiveness of 12 months of Lucentis (ranibizumab) in patients with well controlled compared to those with poorly controlled diabetes using an PRN treatment schedule.
- Trial name
- CONTROL (NCT03495765)
- Testing
- Ranibizumab
- Where
- Australia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marsden Eye Specialists
Macular Edema
Diffuse Diabetic Maculopathy With Intravitreal Triamcinolone or Laser
This study compares the use of intravitreous triamcinolone and laser therapy to treat maculopahty in patients with type 2 diabetes mellitus in a short-tem period of 6 months
- Trial name
- NCT00668239
- Testing
- intravitreous triamcinolone, laser therapy
- Where
- 3 sites in Brazil
- Volunteers
- 14 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetic Macular Edema
The Study of CU06-1004 in Patients With Diabetic Macular Edema (DME)
This phase 2a trial is a randomized, open-label, parallel-group study in approximately 60 patients with DME to evaluate the efficacy and safety of CU06-1004 orally administered once daily for 12 weeks.
- Trial name
- NCT05573100
- Testing
- CU06-1004
- Where
- 11 sites in United States, Puerto Rico
- Volunteers
- 67 people
- Sponsor
- Curacle Co., Ltd.
Diabetic Macular Edema
Comparison of VA Guided Versus OCT Guided TER Using Aflibercept for Diabetic Macular Edema (AVOCT Study)
This study will evaluate the effectiveness of aflibercept (Eylea®) using two different treatment protocols in patients with vision loss from diabetic macular edema.
- Trial name
- AVOCT (NCT03394573)
- Testing
- OCT guided treatment arm, VA guided treatment arm
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Type 1 or 2 With Diabetic Retinopathy
Incidence of Macular Edema After Panretinal Photocoagulation (PRPC) Performed in a Single Session Versus Four Sessions in Diabetic Patients.
The aim of this study is to show that PRPC performed in a single session using a Pascal laser leads to better management of the disease (better rate of regression of neovessels, lower risk of a loss of visual acuity in the long…
- Trial name
- Pascal (NCT01766362)
- Testing
- PRPC using Pascal laser
- Where
- 3 sites in France
- Volunteers
- 83 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetic Macular Edema (DME)
Comparison of Bevacizumab and Aflibercept in Treatment of Diabetic Macular Edema
Diabetic macular edema is a frequent complication of long-standing diabetes mellitus in which fluid leaks into the central part of the retina (macula), leading to reduced vision.
- Trial name
- NCT07338097
- Testing
- Aflibercept (2.0 mg), Bevacizumab
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- CMH Multan Institute of Medical Sciences