Clinical trials: Diabetic Nephropathy.
Type 2 Diabetes, Cardiovascular Complication
Effects and Safety of Diabetic GUideline Algorithm Implementation Performed by Primary Care Physicians in the Community
The Effects and Safety of Diabetic GUideline Algorithm Implementation in the Community (GUARD-Community) study is a 2-arm, cluster-randomized control trial to evaluate the effect and safety of guideline algorithm intervention…
- Conditions
- Type 2 Diabetes, Cardiovascular Complication, Diabetic Kidney Disease
- Trial name
- GUARD (NCT05349955)
- Testing
- Intensive guideline algorithm implementation, Conventional guideline algorithm implementation
- Where
- 13 sites in China
- Volunteers
- 5,600 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetic Nephropathy
Phase 2 Study to Evaluate Safety & Efficacy of VPI-2690B in Diabetic Nephropathy Patients
The purpose of this study is to determine whether VPI-2690B Injection is effective in the treatment of diabetic nephropathy.
- Trial name
- NCT02251067
- Testing
- VPI-2690B low dose, VPI-2690B medium dose, VPI-2690B high dose
- Where
- 34 sites in United States, Puerto Rico
- Volunteers
- 165 people
- Sponsor
- Vascular Pharmaceuticals, Inc.
Proteinuric Kidney Disease, Diabetic Nephropathy
Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease
Primary Hypothesis: Aldosterone breakthrough will occur at a far lower frequency during renin inhibition (0-10% over 9 months), alone or in combination with an ARB, compared to conventional ARB therapy (35-45% over 9 months).
- Conditions
- Proteinuric Kidney Disease, Diabetic Nephropathy, Hypertensive Nephrosclerosis, IgA Nephropathy
- Trial name
- NCT01129557
- Testing
- Aliskiren, Valsartan
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Columbia University
Diabetic Kidney Disease
Prognostic Imaging Biomarkers for Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a common complication of diabetes, and is now the most common form of chronic kidney disease. DKD is the leading cause of kidney disease requiring dialysis or kidney transplantation, and its…
- Trial name
- iBEAt (NCT03716401)
- Testing
- MRI (magnetic resonance imaging), US (ultrasound), Renal Biopsy
- Where
- 7 sites in Finland, France and 4 more
- Volunteers
- 500 people
- Sponsor
- University of Leeds
Diabetic Nephropathy
Phase IIa Trial to Determine the Effects of Bardoxolone Methyl on Renal Function in Patients With Diabetic Nephropathy
To determine the effects of three different doses of bardoxolone methyl administered orally on the kidney function (glomular filtration rate) in patients with diabetic nephropathy.
- Trial name
- NCT00664027
- Testing
- RTA 402 (Bardoxolone Methyl)
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Biogen
Diabetic Nephropathy
Naoxintong Capsule for Diabetic Nephropathy With Dampness Retention Pattern: A Multicenter, Randomized, Double-Blind, Placebo-Controlled TrialAcronymNXT-DKD
Diabetic nephropathy (DN) is a leading cause of end-stage kidney disease worldwide and is associated with a high risk of cardiovascular events and mortality.
- Trial name
- NXT-DKD (NCT07698223)
- Testing
- Naoxintong Capsule
- Where
- 8 sites in China
- Volunteers
- 410 people
- Sponsor
- Chen Xiangmei
Type 1 Diabetes Mellitus With Diabetic Nephropathy
Validation of Biomarkers of Diabetic Nephropathy in Type I Diabetic Children
About 30 to 40% of patients suffering from type I diabetes are at risk of developing a diabetic nephropathy (DN) leading more or less rapidly to an end-stage renal disease.
- Trial name
- peeDIAB2 (NCT02164279)
- Testing
- Urinary sample collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
Diabetic Nephropathies, Type 2 Diabetes
Perfenidone in Type 2 Diabetic Patients With Diabetic Neuropathy
The purpose of this study is to determine the effectiveness \& safety of pirfenidone in type 2 diabetic patients with diabetic nephropathy
- Trial name
- PenDaNt (NCT06224790)
- Testing
- Pirfenidone
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sidrah Lodhi
Diabetic Nephropathies, Diabetic Kidney Disease
Formoterol in Diabetes
The purpose of the study is to evaluate if formoterol fumarate is effective in treating patients with diabetic kidney disease. Study participants will be randomly assigned to either receive formoterol fumarate (in addition to…
- Trial name
- NCT07022418
- Testing
- Formoterol furmarate (20 μg)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Medical University of South Carolina
Diabetic Nephropathies, Hypertension
1 Year Trial Telmisartan 80 mg Versus Valsartan 160 mg in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy
The general aim of this study is to compare telmisartan 80 mg with valsartan 160 mg in hypertensive patients with type 2 diabetes and overt nephropathy with adjusted blood pressure beyond the target of 130/80 mmHg after one year…
- Trial name
- NCT00153023
- Testing
- Telmisartan, Valsartan
- Where
- 111 sites in Czechia, Denmark and 11 more
- Volunteers
- 885 people
- Sponsor
- Boehringer Ingelheim
Diabetic Nephropathies
This International Study Tests BI 690517 in Patients With Diabetic Kidney Disease. The Study Tests How 3 Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated
The primary objective of this current trial is to investigate the safety and tolerability of 3 oral doses of BI 690517 over 28 days in female and male patients with diabetic nephropathy as add-on-therapy to Angiotensin Converting…
- Trial name
- NCT03165240
- Testing
- BI 690517, Eplerenone
- Where
- 40 sites in Denmark, France and 8 more
- Volunteers
- 62 people
- Sponsor
- Boehringer Ingelheim
Diabetes
Clinical Characteristics and Disease Burden of Diabetic Patients Based on Tianjin Regional Database
The study aims to investigate the clinical characteristics, treatment, and economic burden of disease of Chinese diabetic/non-diabetic patients with/without established cardiovascular disease (CVD), chronic kidney disease (CKD)…
- Trial name
- NCT04903496
- Where
- China
- Volunteers
- 1,233,162 people
- Sponsor
- Boehringer Ingelheim
Diabetic Nephropathies
Nitric Oxide (NO) Activity and Diabetic Nephropathy
Experimental data suggest that oxidative stress and endothelial dysfunction are key players in the pathogenesis of diabetic nephropathy.
- Trial name
- NCT00136188
- Testing
- Folic Acid
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Type 2 Diabetes Mellitus With Diabetic Nephropathy
A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria
To evaluate the safety and efficacy of IW-1973 in patients with type 2 diabetes mellitus with albuminuria who are on a stable regimen of renin-angiotensin system inhibitors.
- Trial name
- NCT03217591
- Testing
- IW-1973
- Where
- 54 sites in United States
- Volunteers
- 156 people
- Sponsor
- Akebia Therapeutics
Diabetes Mellitus
Prospective Evaluation of Proteinuria and Renal Function in Diabetic Patients With Progressive Renal Disease
The purpose of this study is to evaluate the effects of Crestor (rosuvastatin) and (Lipitor) atorvastatin on urinary protein excretion over 1 year in patients with Type 1 or 2 diabetes with moderate proteinuria and…
- Trial name
- PLANET 1 (NCT00296374)
- Testing
- Rosuvastatin, Atorvastatin
- Where
- 116 sites in United States, Argentina and 9 more
- Volunteers
- 353 people
- Sponsor
- AstraZeneca
ANCA Associated Vasculitis, Extramembranous Glomerulopathy
Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis
The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.
- Conditions
- ANCA Associated Vasculitis, Extramembranous Glomerulopathy, Nephrotic Syndrome, Minimal Change, Interstitial Nephritis
- Trial name
- PROTECT-Fi (NCT07010250)
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Kidney Disease stage3 and 4, Type 2 Diabetes Mellitus
Pentoxifylline Effect in Patients With Diabetic Nephropathy.(PENFOSIDINE STUDY)
One of the purposes of the management of the patient with chronic kidney disease (CKD)is to slow the decline of renal function. The mechanisms by which the renal function declines involve inflammatory and fibrotic responses due…
- Trial name
- PENFOSIDINE (NCT03664414)
- Testing
- pentoxifylline
- Where
- Mexico
- Volunteers
- 196 people
- Sponsor
- Maria Eugenia Galván Plata
Diet Modification, Diabetic Kidney Disease
Effect of the Teleconsultation of Renal Nutrition on Renal Function and Glycemic Control in Patients With DKD
The modern era is characterized by progress, development and social and economic globalization. Currently the electronic technology has applications in a wide variety of work areas. A clear example of this, is telemedicine.
- Conditions
- Diet Modification, Diabetic Kidney Disease, Chronic Kidney Diseases
- Trial name
- NCT03344549
- Testing
- Renal nutrition teleconsultation, Face-to-face consultation of renal nutrition
- Where
- Mexico
- Volunteers
- 53 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Type 2 Diabetes Mellitus, Diabetic Nephropathy
Effects of Spironolactone Combination Therapy on Proteinuria, Kidney Function, and Blood Pressure
The detrimental effects of aldostrone are not adequately arrested by the use of angiotensin converting enzyme (ACE), angiotensin II receptor blocker (ARB) or a combination of both.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Nephropathy, Essential Hypertension
- Trial name
- NCT01667614
- Testing
- spironolacone 25 mg tablets added to losartan
- Where
- Iran
- Volunteers
- 136 people
- Sponsor
- Tehran University of Medical Sciences
Diabetic Nephropathy, Hypertension
Effect of Green Tea (Epigallocatechin Gallate) on Albuminuria in Patients With Diabetic Nephropathy.
The purpose of this study is to determine the safety and effect of green tea (epigallocatechin gallate) in albuminuria in diabetic patients and nephropathy.
- Trial name
- NCT01923597
- Testing
- Green tea extract
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Campinas, Brazil