Clinical trials: Diabetic Neuropathy, Painful
Diabetic Peripheral Neuropathic Pain (DPN)
Effect of Trimetazidine on Endothelin-1 and Clinical Outcomes of Patients With Diabetic Peripheral Neuropathy
The goal of this clinical trial is to investigate if trimetazidine can improve clinical outcomes of patients with diabetic peripheral neuropathy.
- Trial name
- NCT07794475
- Testing
- Trimetazidine Dihydrochloride Tablets
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sara Refaat Azab Metry
Painful Diabetic Neuropathy and Post Herpetic Neuralgia
A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia
The purpose of this study is to assess the efficacy and safety of pregabalin for the treatment of diabetic peripheral neuropathy (DPN) or postherpetic neuralgia (PHN)
- Trial name
- NCT00629681
- Testing
- Pregabalin
- Where
- 46 sites in Germany
- Volunteers
- 217 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Neuropathic Pain, Diabetes Mellitus
Eye Movement Desensitization and Reprocessing (EMDR) as a Treatment for Chronic Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to investigate the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy in reducing pain intensity in individuals with chronic painful diabetic neuropathy (PDN).
- Trial name
- EMDR4CPDN (NCT06171230)
- Testing
- Eye Movement Desensitization and Reprocessing, Attention control phase
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Dijklander Ziekenhuis
Diabetic Peripheral Neuropathy
Laser Therapy for Diabetic Peripheral Neuropathic Pain
The proposed study is a randomized, double-blinded clinical trial to evaluate the efficacy of a course of laser therapy on peripheral neuropathic pain in persons with diabetes.
- Trial name
- NCT02328911
- Testing
- Laser treatment
- Where
- United States
- Sponsor
- University of Miami
Diabetic Peripheral Neuropathy (DPN)
Far-Infrared Socks for Neuropathic Pain and Nerve Function in Diabetic Patients
This study aims to evaluate the effectiveness of far-infrared radiation (FIR) emitting socks in improving neuropathic pain, nerve conduction, and quality of life in patients with diabetic peripheral neuropathy (DPN).
- Trial name
- FIR-DPN (NCT06880484)
- Testing
- Far-Infrared Radiation (FIR) Socks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- TC Erciyes University
Diabetic Peripheral Neuropathy
Combined Effects of INF and OEP in Patients With Diabetic Peripheral Neuropathy
DPN often leads to balance issues, sensory deficits, and chronic pain, which can severely impact daily functioning and independence.
- Trial name
- NCT07274735
- Testing
- Intraneural facilitation therapy, Otago exercise program, Intraneural facilitation therapy with Otago exercise program
- Where
- Pakistan
- Volunteers
- 65 people
- Sponsor
- Riphah International University
Painful Diabetic Peripheral Neuropathy
Painful Diabetic Peripheral Neuropathy Study of Chinese OutPatiEnt
Painful Diabetic peripheral Neuropathy Study of Chinese OutPatiEnt (PDN-SCOPE): a multi-center cross-sectional registry study of clinical characteristics and treatment survey of PDN in China
- Trial name
- SCOPE (NCT03520608)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking University Third Hospital
Diabetic Peripheral Neuropathic Pain
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
- Trial name
- NCT06628908
- Testing
- Suzetrigine, Pregabalin
- Where
- 76 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Painful Diabetic Neuropathy
A Trial to Assess the Efficacy and Safety of 400mg/Day Lacosamide in Subjects With Painful Diabetic Neuropathy
The purpose of this trial is to assess whether 400mg/day of lacosamide is effective in reducing pain caused by distal diabetic neuropathy.
- Trial name
- NCT00350103
- Testing
- SPM 929
- Where
- Germany
- Volunteers
- 551 people
- Sponsor
- UCB Pharma
Diabetic Neuropathy, Chemotherapy Induced Neuropathy
A Clinical Outcomes Study to Measure Reduction in Pain and Numbness During Administration of an Amino Acid Formulation in Subjects Diagnosed With Peripheral Neuropathy
A clinical outcomes study measuring reduction in pain and numbness experienced in four types of peripheral neuropathy patients during 60 day administration of the an amino acid formulation.
- Conditions
- Diabetic Neuropathy, Chemotherapy Induced Neuropathy, HIV Neuropathy, Trauma Induced Neuropathy
- Trial name
- Neuron012703 (NCT01537705)
- Testing
- Neuron012703 (Medical Food)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Targeted Medical Pharma
Painful Diabetic Peripheral Neuropathy (PDPN)
Cryoneurolysis for Painful Diabetic Neuropathy of the Foot
The study is a single-center, randomized, participant- and observer-masked, human-subjects, post-market clinical pilot study to investigate the use of ultrasound-guided percutaneous cryoneurolysis to treat diabetic neuropathy of…
- Trial name
- NCT06646731
- Testing
- cryoneurolysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Diabetic Foot, Diabetic Neuropathies
US & HILT Comparative Effect on Neuropathic Pain, Strength & QOF in Diabetic Foot
To compare the effects of therapeutic ultrasound and high intensity laser therapy on neuropathic pain , strength and quality of life in patients with diabetic foot
- Trial name
- NCT06479577
- Testing
- ultrasound, high intensity laser therapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Painful Diabetic Peripheral Neuropathy
Efficacy of Pregabalin and Duloxetine in Patients With PDPN: the Effect of Pain on Cognitive Function, Sleep and Quality of Life
The objective and the purpose of the trial is to: assess the efficacy of Pregabalin Krka and Dulsevia® in patients with PDPN, investigate the effect of Pregabalin Krka and Dulsevia® on pain and on quality of life (QOL)…
- Trial name
- BLOSSOM (NCT04246619)
- Testing
- Pregabalin, Duloxetine
- Where
- 13 sites in Croatia, North Macedonia and 3 more
- Volunteers
- 254 people
- Sponsor
- KRKA
Painful Diabetic Neuropathy
The Benefits of Vitamin D 5000 IU as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient
Diabetic neuropathy is one of the micro-vascular complications of diabetes, 30-50% occurring in all diabetic patients. This complication is one of the major cause of morbidity and mortality in diabetic patientsand leading to a…
- Trial name
- NCT04689958
- Testing
- Standard therapy, Vitamin D 5,000IU Oral Tablet
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Duta Wacana Christian University
Painful Diabetic Neuropathy
A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y
This trial is assessing the analgesic efficacy and safety of a new central analgesic in subjects with pain due to diabetic peripheral neuropathy (DPN).
- Trial name
- NCT01056315
- Testing
- GRT3938Y
- Where
- 61 sites in United States
- Volunteers
- 553 people
- Sponsor
- Grünenthal GmbH
Peripheral Arterial Disease, Painful Diabetic Neuropathy
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
Peripheral arterial disease (PAD) affects over 230 million adults worldwide and is a highly morbid, costly, and disabling condition.
- Conditions
- Peripheral Arterial Disease, Painful Diabetic Neuropathy, Diabetes Mellitus, Type 2, Chronic Pain
- Trial name
- NCT06480786
- Testing
- Spinal cord stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Nebraska
Painful Diabetic Peripheral Neuropathy (PDPN)
Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral Neuropathy
A phase 3, prospective, adaptive, randomized, multicenter, double-blind, triple-masked, parallel clinical trial to evaluate the efficacy and safety of N0750 in relieving pain associated with painful diabetic peripheral neuropathy…
- Trial name
- ENFORCE (NCT06715462)
- Testing
- N0750, Cymbalta®, Lyrica®
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Painful Diabetic Neuropathy, Diabetic Neuropathies, Painful
Graded Exposure in Patients With Painful Diabetic Neuropathy
Objective: To investigate the effects of a cognitive behavioural intervention targeting specific fears in patients with painful diabetic neuropathy, on physical activity and quality of life.
- Conditions
- Painful Diabetic Neuropathy, Diabetic Neuropathies, Painful, Neuralgia, Diabetic
- Trial name
- PDN&GEXP (NCT03066570)
- Testing
- Graded Exposure
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maastricht University Medical Center
Diabetic Neuropathy
A Study of Effectiveness and Safety of JNJ-42160443 in Patients With Diabetic Painful Neuropathy
The purpose of this study is to evaluate the analgesic efficacy, safety and tolerability of multiple doses of JNJ-42160443 when administered as a single, subcutaneous injection every 28 days to patients with diabetic painful…
- Trial name
- NCT00993018
- Testing
- JNJ-42160443 (1 mg), JNJ-42160443 (3 mg), JNJ-42160443 (10 mg)
- Where
- 23 sites in United States
- Volunteers
- 77 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetic Neuropathies
Effect of Spinal Cord Stimulation in Painful Diabetic Polyneuropathy
Rationale: Diabetic neuropathy is one of the most common complications of Diabetes Mellitis (DM). Pain is a common symptom of diabetic neuropathy, affecting 11-34% of patients suffering form DM.
- Trial name
- SCS (NCT00802022)
- Testing
- spinal cord stimulation
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center