Clinical trials: Diabetic Polyneuropathy
Peripheral (Sensorimotor) Diabetic Polyneuropathy
To Assess the Bioequivalence of Test Oral Formulation of Alpha Lipoic Acid 600 mg HR Film Coated Tablets of Ilko Ilac San. Ve Tic. A.S. Versus Reference Thioctacid (Alpha Lipoic Acid) 600 mg HR Film Coated Tablets of Meda Pharma GmbH& CO .KG, Germany.
To assess the bioequivalence of test oral formulation of Alpha Lipoic acid 600 mg HR film coated tablets of Ilko Ilac San. Ve Tic. A.S.
- Trial name
- NCT04214665
- Testing
- Alpha Lipoic acid 600 mg HR film coated tablets
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ilko Ilac San. ve Tic. A.S.
Diabetic Polyneuropathy, Diabetic Gastroparesis
Pilot Study to Evaluate Magnetic Marker Imaging on Diabetic Polyneuropathy and Gastroparesis
The purpose of this study is to determine whether Magnetic Marker Monitoring is an appropriate opportunity to diagnose and to quantify a suspicious gastroparesis in subjects with diabetic polyneuropathy.
- Conditions
- Diabetic Polyneuropathy, Diabetic Gastroparesis, Diabetes Mellitus
- Trial name
- NCT01607684
- Testing
- Magnetic Marker Imaging (MMI) with Magma 3D system
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Oxidative Stress, Diabetic Polyneuropathy
Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy
Aims: To evaluate the effect of ezetimibe/simvastatin and rosuvastatin on oxidative stress and mitochondrial function in patients with DPN.
- Trial name
- NCT02129231
- Testing
- calcined magnesia, Ezetimibe/simvastatin, Rosuvastatin
- Where
- Mexico
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Small Fiber Neuropathy, Diabetic Neuropathies
Diabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study
The aim of work is to study the clinical, electrodiagnostic and neurosonographic characteristics of diabetic patients with small fiber neuropathy in the Egyptian population, and to evaluate both the diagnostic and the prognostic…
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Autonomic Neuropathy, Diabetic Peripheral Neuropathy
- Trial name
- NCT05993871
- Testing
- Clinical Evaluation/Questionnaires, Nerve Conduction Study, Small fiber electrodiagnostic tests
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tanta University
Diabetic Polyneuropathy, Diabetic Foot
The Effect of Mini Trampoline Exercise Program on Diabetic Foot Care Behavior and Polyneuropathy
This study was planned to examine the effect of home-based mini trampoline exercise program on diabetic foot care behavior and diabetic polyneuropathy in Type 2 diabetes patients.
- Conditions
- Diabetic Polyneuropathy, Diabetic Foot, Type 2 Diabetes
- Trial name
- NCT05668325
- Testing
- Mini trampoline exercise group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Diabetes Mellitus, Type 2, Polyneuropathy Diabetes
Resistance Training in Patients With Diabetic Neuropathy
This is a population-based study of type 2 diabetes patients with and without neuropathy recruited from the Danish National Type 2 Diabetes cohort (DD2).
- Conditions
- Diabetes Mellitus, Type 2, Polyneuropathy Diabetes, Diabetes Complications, Diabetic Peripheral Neuropathy
- Trial name
- NCT03252132
- Testing
- 12-week resistance training
- Where
- Denmark
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Danish Pain Research Center
Neuropathic Pain
Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy
Epinosine B Forte ampoule is an intramuscular injectable supplement containing adenosine triphosphate (ATP), Cocarboxylase (vitamin B1 derivative), vitamin B12, and nicotinamide (vitamin B3).
- Trial name
- NCT07296354
- Testing
- adenosine triphosphate, Vitamin B Complex
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Egyptian International Pharmaceutical Industries Co
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy
Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study
The project aims to investigate the validity, and reliability of outcome measures of muscle strength, functioning (gait, balance, and fine motor skills), physical activity, and patient-reported outcome measures of functioning…
- Conditions
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy, POEMS Syndrome, Multifocal Motor Neuropathy
- Trial name
- PolyImPAct (NCT06040567)
- Testing
- Validity and reliability of outcome measures in polyneuropathy, Healthy controls
- Where
- Denmark
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetic Polyneuropathy, Magnetic Resonance Imaging
Diffusion Tensor Imaging of Median Nerve in Diabetic Peripheral Neuropathy
This study is a diagnostic accuracy study that aims to evaluate the role of DTI in evaluation of DPN in comparison to clinical scores and nerve conduction studies (NCS).
- Trial name
- NCT03934970
- Testing
- Diffusion tensor imaging of peripheral nerves
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Normal Eyes of Subjects Without Diabetes Mellitus, Subjects With Diabetes Mellitus Type 2 Without Coexisting DPN
Repeatability of Static & Dynamic Composite Confocal Microscopy for Assessment of the Corneal Nerve Fiber Plexus in Early Diabetic Polyneuropathy
This prospective study was was divided into 2 parts and carried out at 2 sites in Germany. Part 1 assessed Repeatability in healthy, non-diabetic population (Group "control").
- Conditions
- Normal Eyes of Subjects Without Diabetes Mellitus, Subjects With Diabetes Mellitus Type 2 Without Coexisting DPN, Subjects With Diabetes Mellitus Type 2 With Coexisting Early to Moderate DPN
- Trial name
- NCT05326958
- Testing
- HRT RCM, HRT RCM-E
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Diabetes Mellitus, Type 2, Polyneuropathy Diabetes
24-hour Blood Pressure Dynamics and Autonomic Adrenergic Regulation in Type 2 Diabetics
Autonomic neuropathy is a common complication of type 2 diabetes mellitus. Symptoms from cardiovascular autonomic neuropathy include, dizziness, orthostatic hypotension and insufficient heart rate and blood pressure (BP)…
- Conditions
- Diabetes Mellitus, Type 2, Polyneuropathy Diabetes, Autonomic Neuropathy, Diabetic Neuropathies
- Trial name
- NCT04208295
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetic Polyneuropathy
A Double-Blind, Placebo-Controlled Study of Fermented Deglycyrrhizinated Licorice Extract
This double-blind, placebo-controlled study evaluated the efficacy of oral α-amylase enzyme replacement therapy in treating early-stage diabetic polyneuropathy (DPN).
- Trial name
- NCT07148804
- Testing
- Fermented Deglycyrrhizinated Licorice, Non-fermented Deglycyrrhizinated Licorice
- Where
- Egypt
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Helwan University
Diabetes Mellitus, Type 2, Diabetic Polyneuropathy
Use of GDF15 as a Biomarker for Early Diagnosis of DM and Monitoring of Progress of Complications in Asians
Significant differences in the expression of individual Growth Differentiation Factor 15 (GDF-15) proteins among Taiwanese harboring different mitochondrial genotypes are noted, and their blood serum levels also exhibited…
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Polyneuropathy, Diabetic Nephropathies
- Trial name
- NCT04119167
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Polyneuropathies, Diabetic Complications Neurological
Is Serum Irisin Level a Biomarker in Diabetic Polyneuropathy?
Diabetic polyneuropathy is a common complication of type 2 diabetes mellitus associated with sensory impairment and functional disability. Irisin is a myokine that has been implicated in glucose metabolism and neuroprotection.
- Conditions
- Polyneuropathies, Diabetic Complications Neurological, Diabetes Mellitus Type 2
- Trial name
- NCT07734597
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- GÜLDEN ANATACA
Diabetic Patients With Polyneuropathy
Improving Mobility in Diabetic Patients Through Resistance Training
Impaired mobility is a major health problem affecting many subjects with diabetes mellitus. It is associated with loss of quality of life and it is a strong predictor for poor health outcomes.
- Trial name
- NCT00759265
- Testing
- resistance training
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes Mellitus, Diabetic Polyneuropathy
Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Diabetic Polyneuropathy
This study aimed to evaluate talar cartilage thickness in individuals with diabetic polyneuropathy using ultrasonography and to compare the findings with those of healthy individuals.
- Trial name
- NCT07801131
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Insulin-like Growth Factor I, Insulin-like Growth Factor II
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
Background: The pathogenetic factors underlying development of diabetic polyneuropathy (DP) remain unclear. Reduced neurotrophic stimulation has been proposed as a possible mechanism.
- Conditions
- Insulin-like Growth Factor I, Insulin-like Growth Factor II, Diabetes Complications, Polyneuropathies
- Trial name
- NCT01718015
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Carpal Tunnel Syndrome (CTS), Diabetic Polyneuropathy
Impact of Diabetic Polyneuropathy on Carpal Tunnel Syndrome: Shear Wave Elastography, Ultrasound, and Hand Function
This observational study examines changes in the median nerve in patients diagnosed with diabetic polyneuropathy (DPN) and carpal tunnel syndrome (CTS) using shear wave elastography, microvascular imaging, and cross-sectional…
- Conditions
- Carpal Tunnel Syndrome (CTS), Diabetic Polyneuropathy, Shear Wave Elastography, Median Nerve
- Trial name
- NCT06933511
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Ultrasonography, Peroneal Neuropathies
High-resolution Ultrasound in Lower Extremity Nerves and Common Fibular Neuropathies.
This study establishes reference material of selected lower extremity nerves at pre-defined sites with high-resolution ultrasound.
- Trial name
- NCT03560505
- Testing
- Ultrasound protocol
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sándor Beniczky
Diabetes Mellitus, Polyneuropathies
Neurogenic Inflammation in Diabetes
Polyneuropathy is a complication of diabetes mellitus which leads to decreased sensation in arms and legs. This in turn can lead to the development of (infected) foot ulcers.
- Conditions
- Diabetes Mellitus, Polyneuropathies, Arthropathy, Neurogenic
- Trial name
- NCT01370837
- Testing
- Intracutaneous injection of Candida albicans antigen., Temperature measurement.
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center