Clinical trials: Diabetic Retinal Disease
Diabetic Macular Edema
Dose Ranging Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Diabetic Macular Edema
The purpose of this study is to determine the safety and efficacy of an ocular sirolimus (rapamycin) formulation at various doses in patients with diabetic macular edema.
- Trial name
- NCT00656643
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Santen Inc.
Proliferative Diabetic Retinopathy
A Pilot Study on the Effects of ILARIS® on Patients With Proliferative Diabetic Retinopathy (PDRP)
The pilot study evaluates the efficacy and safety of Canakinumab (ILARIS®) in subjects with proliferative diabetic retinopathy secondary to type 1 and 2 diabetes.
- Trial name
- ILARIS (NCT01589029)
- Testing
- CANAKINUMAB (ILARIS®)
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- PD Dr. med. Stephan Michels
Macular Edema
Japanese Safety Study of VEGF Trap-Eye in DME (Diabetic Macular Edema)
This study will assess the safety and tolerability of intravitreally (IVT) administered VEGF Trap-Eye in Japanese subjects with diabetic macular edema (DME) over the period of one year.
- Trial name
- VIVID-Japan (NCT01512966)
- Testing
- VEGF Trap-Eye (BAY86-5321)
- Where
- 18 sites in Japan
- Volunteers
- 73 people
- Sponsor
- Bayer
Glaucoma, Age-related Macular Degeneration
Evaluation of New Head-mounted Visual Aids Among Patients With Low Vision
Glaucoma, age-related macular degeneration (AMD), retinitis pigmentosa, RP, diabetic retinopathy (DR) are the most common blinding eye diseases in the world.
- Conditions
- Glaucoma, Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy
- Trial name
- NCT06076720
- Testing
- New head-mounted visual aids
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Diabetic Retinopathy
A Multicenter, Randomized, Double-blind Non-inferiority Trial to Evaluate the Efficacy and Safety of Entelon®
This was a multicentre, randomised, double-blind controlled study that compared the efficacy and safety of V. vinifera extract, calcium dobesilate (CD), and placebo in subjects with DME.
- Trial name
- NCT03962296
- Testing
- Vitis vinifera extract, Calcium Dobesilate
- Volunteers
- 153 people
- Sponsor
- Hanyang University
Central Retinal Vein Occlusion, Proliferative Diabetic Retinopathy
Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion
The purpose of this study is to look at how effective, safe, and well tolerated Intravitreal Aflibercept Injection is in subjects with Central Retinal Vein Occlusion (CRVO) or Proliferative Diabetic Retinopathy (PDR).
- Trial name
- ANDROID (NCT01724554)
- Testing
- Intravitreal Aflibercept Injection
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ophthalmic Consultants of Boston
Diabetic Retinopathy, Artificial Intelligence
Implementation of an Integrated System of Artificial Intelligence and Referral Tracking for Real-time Diabetic Retinopathy Screening
This research study aims to bring an artificial intelligence system to screen for diabetic retinopathy (DR) along with referral tracking systems to the screening unit in Uthai Hospital in Phra Nakhon Sri Ayutthaya to assess the…
- Conditions
- Diabetic Retinopathy, Artificial Intelligence, Screening
- Trial name
- NCT05166122
- Testing
- Artificial Intelligence
- Where
- Thailand
- Volunteers
- 1,600 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Diabetic Macular Edema, Macular Ischemia
Effect of Ranibizumab Versus Bevacizumab on the Macular Perfusion in Diabetic Macular Edema
The Early Treatment Diabetic Retinopathy Study (ETDRS) group founded guidelines for treating patients with clinically significant diabetic macular edema (DME) with focal/grid macular laser photocoagulation.
- Conditions
- Diabetic Macular Edema, Macular Ischemia, Diabetic Retinopathy, Vascular Endothelial Growth Factor Overexpression
- Trial name
- REBEL (NCT04991350)
- Testing
- Intravitreal ranibizumab, Intravitreal bevacizumab
- Where
- Egypt
- Volunteers
- 5 people
- Sponsor
- Cairo University
Diabetic Retinopathy
Self-testing Diagnosis Imaging Model for Diabetic Retinopathy
This is a prospective clinical study. At the Shaoguan Diabetic Eye Screening Programme, patients ages 30-80 will undergo the two diagnostic models: (1) in a remote diagnostic clinic site, patients undergo a self-testing device…
- Trial name
- NCT05223556
- Testing
- Full Self-Diagnostic device in a remote diagnostic imaging site, Human imager operated diagnostic device in the hospital
- Where
- China
- Volunteers
- 167 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Proliferative Diabetic Retinopathy
Analgesic Effect of Etoricoxib (ARCOXIA®) 120MG During Retinal Laser Photocoagulation
The study wants to show if the medication etoricoxib 120 mg have reduces the patients pain during the laser photocoagulation, for diabetic retinopathy.
- Trial name
- NCT00529594
- Testing
- Etoricoxib (Treatment Group)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Macular Edema, Diabetic
Treat-and-extend Regimen of Aflibercept in Diabetic Macular Edema (VIBIM Study)
Efficacy of Treat-and-extend regimen (TER) using aflibercept in diabetic macular edema (DME) will be evaluated.
- Trial name
- VIBIM (NCT02788877)
- Testing
- aflibercept
- Where
- 8 sites in South Korea
- Volunteers
- 48 people
- Sponsor
- Pusan National University Hospital
Diabetes Mellitus, Diabetic Retinopathy
A Phase 2 Study Exploring The Safety And Efficacy Of Novel Drug Treatment In Subjects With Diabetic Macular Edema (DME)
This study will evaluate the safety and efficacy of AG-014699 in diabetic patients
- Trial name
- NCT00457470
- Testing
- AG-014699
- Sponsor
- Pfizer
Diabetic Retinopathy
A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm
Study GR41675 is a Multicenter, Randomized Study in Participants with Diabetic Retinopathy (DR) Without Center-Involved Diabetic Macular Edema (CI-DME) to Evaluate the Efficacy, Safety of the Port Delivery System with Ranibizumab…
- Trial name
- PAVILION (NCT04503551)
- Testing
- PDS Implant Pre-Filled with 100 mg/mL Ranibizumab, Intravitreal Ranibizumab 0.5 mg Injection
- Where
- 65 sites in United States, Puerto Rico
- Volunteers
- 174 people
- Sponsor
- Hoffmann-La Roche
High Risk Proliferative Diabetic Retinopathy
Prospective, Randomized, Multicenter, Open Label, Phase II Study to Access Efficacy and Safety of Lucentis® Monotherapy Compared With Lucentis® Plus Panretinal Photocoagulation (PRP) and PRP in the Treatment of Patients With High Risk Proliferative Diabetic Retinopathy
The purpose of this trial is to evaluate safety and to compare the efficacy of intravitreous injection of ranibizumab alone (0.5 mg), versus combination of intravitreous injection of ranibizumab (0.5 mg) plus panretinal…
- Trial name
- NCT01280929
- Testing
- Panretinal Photocoagulation (PRP), Intravitreous injection of ranibizumab
- Where
- 7 sites in Portugal
- Volunteers
- 54 people
- Sponsor
- José Cunha-Vaz
Diabetes Mellitus, Diabetic Retinopathy (DR)
Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Supply Side
The goal of this clinical trial is to determine whether integration of vision care into the DM treatment system, by providing specific recommendations to doctors for management of diabetes alongside feedback on positive eye exams…
- Trial name
- NCT06968637
- Testing
- care recommendations
- Where
- 2 sites in Bangladesh
- Volunteers
- 336 people
- Sponsor
- Orbis
Diabetic Retinopathy, Retinal Neovascularisation
Ranibizumab in Diabetic Vitrectomy. A Prospective, Randomised Controlled Trial of Ranibizumab Pre-treatment in Diabetic Vitrectomy - a Pilot Study
This study will evaluate the effect of ranibizumab on patients undergoing vitrectomy surgery for the complications of diabetic retinopathy.
- Trial name
- RaDiVit (NCT01306981)
- Testing
- Ranibizumab, Saline
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Diabetic Retinopathy, Diabetic Macular Edema
Adaptive Optics for Ophthalmic Technologies
This is a feasibility study to assess the use of wide field adaptive optics optical coherence tomography (WF-AO-OCT) to determine whether there are structural differences in the peripheral retina in participants diagnosed with…
- Trial name
- NCT02826655
- Testing
- WF-AO-OCT
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetic Retinopathy, Retinal Vein Occlusion
Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease
This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in…
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Hypertension,Essential, Retinal Vascular Disorder
- Trial name
- OCTA-RVD (NCT04505618)
- Testing
- Swept-Source (SS) OCT Angiography, Spectral-Domain (SD) OCT Angiography, Fundus Imaging
- Where
- United States
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Proliferative Diabetic Retinopathy, Diabetic Retinopathy
Single Session vs Multiple-Session Panretinal Photocoagulation for Treatment of Proliferative Diabetic Retinopathy
Proliferative diabetic retinopathy (PDR) is the leading cause for blindness in working-age adults. The current gold standard treatment for PDR is panretinal photocoagulation (PRP).
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabetic Retinopathy Visually Threatening, Diabetic Macular Edema
- Trial name
- SMART-PRP (NCT06549023)
- Testing
- Single-session panretinal PRP (SS-PRP), Multiple-session panretinal PRP (MS-PRP)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Age-Related Macular Degeneration, Retinal Vein Occlusion
Resistance to Antibiotics in Patients Receiving Eye Injections
The administration of short courses of topical antibiotic drops before and/or after intravitreal injections is a common practice, but increasing evidence suggests this may not lower the risk of infectious endophthalmitis and…
- Conditions
- Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy
- Trial name
- NCT02126423
- Testing
- Conjunctival and nasopharyngeal swabs
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Prism Vision Group
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