Clinical trials: Diabetic Retinopathy, completed
Age-related Macular Degeneration, Diabetic Retinopathy
Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study)
To compare the efficacy and comfort of two FDA approved pre-injection antiseptics when used for intravitreal injections.
- Conditions
- Age-related Macular Degeneration, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- PAVE (NCT04018482)
- Testing
- Povidone Iodine, Hypochlorous Acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- California Retina Consultants
Age-Related Macular Degeneration, Retinal Vein Occlusion
Resistance to Antibiotics in Patients Receiving Eye Injections
The administration of short courses of topical antibiotic drops before and/or after intravitreal injections is a common practice, but increasing evidence suggests this may not lower the risk of infectious endophthalmitis and…
- Conditions
- Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy
- Trial name
- NCT02126423
- Testing
- Conjunctival and nasopharyngeal swabs
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Prism Vision Group
Diabetic Retinopathy
A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy
The study's main purpose is to asses the safety, tolerability, and effect of oral administration of RG7774 on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe non-proliferative diabetic…
- Trial name
- CANBERRA (NCT04265261)
- Testing
- RG7774
- Where
- 68 sites in United States, Australia and 5 more
- Volunteers
- 139 people
- Sponsor
- Hoffmann-La Roche
Diabetic Retinopathy
Trial to Assess the Efficacy of Neuroprotective Drugs Administered Topically to Prevent or Arrest Diabetic Retinopathy
To assess whether neuroprotective drugs administered topically (somatostatin and brimonidine) are able to prevent or arrest the development and progression of neurodegenerative changes
- Trial name
- EUROCONDOR (NCT01726075)
- Testing
- COLIRIOBCN070660, Brimonidine
- Where
- 11 sites in Denmark, France and 5 more
- Volunteers
- 450 people
- Sponsor
- BCN Peptides
Pain
Intravitreal Injection Site and Perceived Pain
The objective of this study is to explore the perception of pain during intravitreal injection related to the distance of the entry site from the limbus.
- Trial name
- NCT05640895
- Testing
- Intravitreal injection site
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
High Risk Proliferative Diabetic Retinopathy
Prospective, Randomized, Multicentre, Open-label, Phase II / III Study to Assess Efficacy and Safety of Ranibizumab 0.5 mg Intravitreal Injections Plus Panretinal Photocoagulation (PRP) Versus PRP in Monotherapy in the Treatment of Subjects With High Risk Proliferative Diabetic Retinopathy.
This study is a prospective, randomized, multicentre, open label study that intents to compare the efficacy and safety of ranibizumab 0.5 mg Intravitreal (ITV) injections plus Panretinal Photocoagulation versus Panretinal…
- Trial name
- PROTEUS (NCT01941329)
- Testing
- Panretinal Photocoagulation (PRP), Intravitreous injection of ranibizumab
- Where
- 13 sites in France, Italy and 2 more
- Volunteers
- 94 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Epiretinal Membrane, Macular Hole
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
The aim of this study is to test the efficacy of the combination of dye Lutein, Zeaxanthin and brilliant blue to stain the internal limiting membrane as well as the epiretinal membranes during the Vitrectomy surgery.
- Conditions
- Epiretinal Membrane, Macular Hole, Proliferative Diabetic Retinopathy
- Trial name
- NCT01627977
- Testing
- Dye of Lutein, Zeaxanthin and Brilliant Blue
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Type 1 Diabetes, Diabetic Retinopathy
Incidence of Retinopathy and Associated Risk Factors in Children and Young Adults With Type 1 Diabetes in Denmark
The objective of this study is to clarify the current diabetic status, including development of complications, in a nationwide cohort of type 1 diabetics, who were last examined together in a large study in 1995.
- Trial name
- DCPD1987 (NCT01785667)
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- Odense University Hospital
DIABETES MELLITUS, DIABETIC RETINOPATHY
Contrast Sensitivity and Diabetic Macular Edema
Contrast sensitivity is a tool use to evaluate the visual function in all patients. It can be modified by different pathologies or by age.
- Conditions
- DIABETES MELLITUS, DIABETIC RETINOPATHY, MACULAR EDEMA
- Trial name
- NCT02217306
- Where
- Mexico
- Volunteers
- 132 people
- Sponsor
- Hospital Juarez de Mexico
Diabetic Retinopathy, Diabetes Mellitus
Sorbinil Retinopathy Trial (SRT)
To evaluate the safety and efficacy of the investigational drug sorbinil, an aldose reductase inhibitor, in preventing the development of diabetic retinopathy and neuropathy in persons with insulin-dependent diabetes.
- Trial name
- NCT00000159
- Testing
- Sorbinil
- Sponsor
- National Eye Institute (NEI)
Retinal Degeneration, Diabetic Retinopathy
Clinical and Pathophysiological Description of Ocular Ischemic Syndrome
The purpose of this study is to characterize the disease Ocular Ischemic Syndrome.
- Trial name
- NCT00403195
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Diabetic Retinopathy
Assessment of EyeArt Performance With Retinal Cameras
The study evaluates the performance of the EyeArt system for detecting diabetic retinopathy from images captured using retinal cameras and operators.
- Trial name
- NCT04984200
- Testing
- Retinal imaging, Mydriatic Agent
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Eyenuk, Inc.
Proliferative Diabetic Retinopathy
Bevacizumab and Long Acting Gas in Diabetic Vitrectomy
Persistent or recurrent vitreous hemorrhage after vitrectomy for diabetic retinopathy complications is a common occurrence with an incidence of 12% to 63%.
- Trial name
- NCT00656435
- Testing
- Bevacizumab
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Diabetic Nephropathy, Diabetic Retinopathy
Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT)
Investigators with the goal of optimizing glycemic and blood pressure control saw type 1 diabetic patients weekly. A control group received 3-4 subcutaneous insulin injections per day; an intravenous insulin pulsed infusion group…
- Trial name
- NCT00594152
- Testing
- CIIIT
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Joslin Diabetes Center
Proliferative Diabetic Retinopathy
Analgesic Effect of Etoricoxib (ARCOXIA®) 120MG During Retinal Laser Photocoagulation
The study wants to show if the medication etoricoxib 120 mg have reduces the patients pain during the laser photocoagulation, for diabetic retinopathy.
- Trial name
- NCT00529594
- Testing
- Etoricoxib (Treatment Group)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Proliferative Diabetic Retinopathy - High Risk
Patient Comfort Using Green vs. Yellow Pan Retinal Photocoagulation
Our aim is to compare patient comfort when using the 532 nanometer (green) wavelength laser to the 577 nanometer (yellow) wavelength laser during pan retinal photocoagulation to treat patients with diabetic retinopathy.
- Trial name
- NCT02995629
- Testing
- laser indirect ophthalmoscopy pan retinal photocoagulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wills Eye
Diabetic Retinopathy, Dyslipidemias
Effects of Oral Fenofibrate on Retinal Thickness and Macular Volume
Lipid levels in the blood are proposed to play a role in the progression of diabetic retinopathy. Lipid levels can be controlled with dyslipidemic drugs, such as fenofibrate.
- Conditions
- Diabetic Retinopathy, Dyslipidemias, Diabetes Mellitus
- Trial name
- NCT04885153
- Testing
- Fenofibrate
- Volunteers
- 36 people
- Sponsor
- Universitas Indonesia
Diabetic Retinopathy, DR, Diabetic Mellitus
Efficacy and Safety of AEYE Diagnostic Screening (AEYE-DS) Software Device for Detection of Diabetic Retinopathy From Digital Funduscopic Images
The goal of this clinical trial is to learn about the performance of the AEYE-DS Software Device to automatically detect more than mild Diabetic Retinopathy (mtmDR) in adult participants diagnosed with Diabetic Mellitus (DM)…
- Trial name
- NCT06241664
- Testing
- AEYE-DS Software
- Where
- United States
- Volunteers
- 601 people
- Sponsor
- AEYE Health Inc
Retinal Detachment, Vitrectomy
Comparative Study of 1000 Centistoke Versus 5000 Centistoke Silicone Oil for Repair of Complex Retinal Detachments
The purpose of this study is to assess the retinal redetachment rates with 1000 centistoke versus 5000 centistoke silicone oil tamponade for repair of complex retinal detachments.
- Conditions
- Retinal Detachment, Vitrectomy, Proliferative Vitreoretinopathy, Diabetic Retinopathy
- Trial name
- NCT01255293
- Testing
- 1000 centistoke silicone oil, 5000 centistoke silicone oil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mid Atlantic Retina
Diabetic Retinopathy, Diabetic Retinal Disease
Nursing Intervention Based on Stress Adaptation Theory for Patients Undergoing Diabetic Retinal Laser Surgery
This randomized controlled study evaluated whether a nursing intervention based on stress adaptation theory could improve pain trajectory and procedural tolerance in patients undergoing ambulatory retinal laser photocoagulation…
- Trial name
- NCT07544381
- Testing
- Nursing Intervention Based on Stress Adaptation Theory, Routine Peri-Procedural Care
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong