Clinical trials: Diabetic Retinopathy, completed
Diabetic Retinopathy
Pharmacological Intervention in Diabetic Retinopathy
The purpose of this study is to determine if diabetic retinopathy can be treated with prostaglandin analogues, prostaglandin synthesis inhibitors or carbonic anhydrases inhibitors.
- Trial name
- XAVOT (NCT00619034)
- Testing
- Latanoprost, diclofenac and dorzolamide (eyedrops), Diclofenac, Dorzolamide
- Where
- Denmark
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetic Retinopathy, Macular Edema
Visual Function, Center Point Thickness and Macular Volume After Photocoagulation
The purpose of this study is to correlate changes of visual function three weeks after photocoagulation for macular edema, with changes of center point thickness and macular volume.
- Trial name
- NCT00906659
- Where
- Mexico
- Volunteers
- 89 people
- Sponsor
- Hospital Juarez de Mexico
Diabetic Retinopathy, Oxidative Stress
Combined Antioxidant Therapy on Oxidative Stress in Aqueous and Vitreous Humor of Diabetic Retinopathy Patients
The present study aims to support previous research on the effects of antioxidant therapy on the outcome of diabetic retinopathy and local oxidative stress values.
- Conditions
- Diabetic Retinopathy, Oxidative Stress, Diabetes
- Trial name
- NCT04071977
- Testing
- Combined antioxidant therapy
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Diabetes, Retinopathy
Feasibility of an Intervention to Increase Diabetic Retinopathy Screening Attendance
The purpose of this study is to test a way to support practices to improve attendance at retinopathy screening among people with diabetes.
- Trial name
- NCT03901898
- Testing
- Training, audit, and reminders, Intervention after 6 months (wait list)
- Where
- Ireland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University College Cork
Diabetic Retinopathy, Diabetic Macular Edema
Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema
This study will evaluate the clinical efficacy of intra-vitreal injections of Ranibizumab (Lucentis) in the treatment of Diabetic Macular Edema as compared to grid/focal laser.
- Trial name
- NCT00387582
- Testing
- Ranibizumab (Lucentis), Argon Laser
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Rocky Mountain Retina Consultants
Diabetic Retinopathy, Clinically Significant Macular Edema
Reduction of Foveal Sensitivity in Eyes With Diabetic Macular Edema
Clinically significant macular edema (CSME) is a thickening of the macula associated with the risk of visual loss, which increases its centre is involved.
- Trial name
- NCT01824862
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Juarez de Mexico
Diabetic Macular Edema
Efficacy and Safety of Brolucizumab vs Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema
The purpose of this study was to evaluate the efficacy and safety of brolucizumab vs. aflibercept in the treatment of patients with visual impairment due to diabetic macular edema (DME).
- Trial name
- KINGFISHER (NCT03917472)
- Testing
- Brolucizumab, Aflibercept
- Where
- 92 sites in United States, Hungary and 3 more
- Volunteers
- 517 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes, Diabetic Retinopathy
Validation Study of RETINA-AI Galaxy™ v2.0, an Automated Diabetic Retinopathy Screening Device
Diabetes affects over 37 million Americans and over 530 million people globally. Each diabetic patient needs at least one retinal exam per year starting immediately at the time of diagnosis if they have Type II diabetes (and…
- Conditions
- Diabetes, Diabetic Retinopathy, Diabetic Macular Edema, Diabetic Eye Problems
- Trial name
- NCT05368623
- Testing
- Color fundus photograph, Optical Coherence Tomography (OCT) of the retina, Mydriatic Agent
- Where
- 3 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- RETINA-AI Health, Inc.
Diabetic Macular Edema (DME), Neovascular (Wet) Age-Related Macular Degeneration
A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324
A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324
- Trial name
- JADE (NCT07484074)
- Testing
- Faricimab, OLN324
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 164 people
- Sponsor
- Ollin Biosciences, Inc.
Proliferative Diabetic Retinopathy
Efficacy of PreOperative Bevacizumab for Diabetic Eye Disease
Reports of the use of intravitreal bevacizumab (Avastin, Genentech) for the reduction of neovascularization in proliferative diabetic retinopathy have demonstrated significant regression in the number of new vessels.
- Trial name
- NCT01041690
- Testing
- Bevacizumab
- Where
- Egypt
- Volunteers
- 19 people
- Sponsor
- Cairo University
Diabetic Retinopathy, Sleep Apnea
CPAP Effect on the Progression of Diabetic Retinopathy in Patients With Sleep Apnea
Objectives: Main objective: To compare the percentage of patients with new microaneurysm or hard exudates after 12 months between the CPAP group and the control group.
- Trial name
- RetinAS (NCT02874313)
- Testing
- Continuous positive airway pressure, Pharmacological treatment, Conventional anti-diabetic diet recommendations
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Hospital Universitario La Paz
Diabetes Mellitus, Diabetic Retinopathy
Intravitreal Long Acting Gas in the Prevention of Early Postoperative Vitreous Hemorrhage in Diabetic Vitrectomy
Recurrent vitreous hemorrhage after vitrectomy for complications of diabetic retinopathy is a common occurrence. The hemorrhage may appear within the first few weeks after surgery or months later.
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Vitreous Hemorrhage
- Trial name
- NCT00155454
- Testing
- Intravitreal long acting gas (10% C3F8)
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- National Taiwan University Hospital
Retinopathy, Diabetic
Diabetic Retinopathy Classification: ETDRS 7-fields vs Widefield Imaging (ClarusDR)
The goal of this observational study is to analyse and compare Diabetic Retinopathy severity level using 30º ETDRS 7-fields and Wide-field Imaging techniques using Clarus 500 (Carl Zeiss Meditech Inc., Dublin, USA) and Optos…
- Trial name
- ClarusDR (NCT05746975)
- Where
- Portugal
- Volunteers
- 81 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Retinopathy
ETDRS PRP With IVR Versus Retinal Photocoagulation Targeted to Ischemic Retina With IVR for the Treatment of PDR
Purpose: To compare panretinal photocoagulation (PRP) as described in ETDRS Study combined with intravitreal injection of ranibizumab (IVR) (ETDRS-PRP group) and retinal photocoagulation targeted to ischemic retina combined with…
- Trial name
- NCT03904056
- Testing
- ISQ-RP, ETDRS-PRP group
- Volunteers
- 23 people
- Sponsor
- São Paulo State University
Macular Edema, Diabetic Retinopathy
Targeted Laser in Diabetic Macular Edema
Our hypothesis is that implementing laser photocoagulation (IGTL) as an adjunctive treatment to intravitreal injections should lead to a significant reduction in the need for intravitreal injections in patients with diabetic…
- Trial name
- TaLa-DME (NCT03751501)
- Testing
- Indocyanine green-Guided Targeted Laser photocoagulation
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Diabetic Retinopathy, Dyslipidemias
Effects of Oral Fenofibrate on Retinal Thickness and Macular Volume
Lipid levels in the blood are proposed to play a role in the progression of diabetic retinopathy. Lipid levels can be controlled with dyslipidemic drugs, such as fenofibrate.
- Conditions
- Diabetic Retinopathy, Dyslipidemias, Diabetes Mellitus
- Trial name
- NCT04885153
- Testing
- Fenofibrate
- Volunteers
- 36 people
- Sponsor
- Universitas Indonesia
Retinal Diseases, Diabetic Retinopathy
Evaluation of Diabetic Retinopathy Using Ultra-Widefield Fundus Images Compared With Two-Field Fundus Images
This study aims to compare the accuracy of evaluating diabetic retinopathy using ultra-widefield fundus images versus two-field fundus images.
- Conditions
- Retinal Diseases, Diabetic Retinopathy, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT05836194
- Where
- China
- Volunteers
- 769 people
- Sponsor
- Ningbo Eye Hospital
Retinopathy, Diabetic
Evaluation of a Health Education Program for Type 2 Diabetes Patients
The goal of this, Retrospective and Prospective Low- Interventional study, is to implement health education interventions to promote self-care and reduce disease complications in DM Type 2 patients at higher risk of…
- Trial name
- EDUCA-DM (NCT06066021)
- Testing
- health educational sessions in diabetic patients type 2.
- Where
- Portugal
- Volunteers
- 27 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Proliferative Diabetic Retinopathy, Angiogenesis
Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis
Fractalkine (FKN) is a chemoattractant and adhesion molecule for leukocytes. Angiogenic effect of FKN also has been reported. We investigate FKN-mediated angiogenesis in ocular angiogenic disorders.
- Trial name
- NCT00728598
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Type 1 Diabetes, Diabetic Retinopathy
The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes
The purpose of this study is to compare the effect of two antihypertensive drugs on retinal vessel diameter in young type 1 diabetics.
- Conditions
- Type 1 Diabetes, Diabetic Retinopathy, Eye Diseases, Diabetes Complications
- Trial name
- NCT00337298
- Testing
- Amlodipine, Lisinopril
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- University of Aarhus