Clinical trials: Diagnoses Disease
Breast Cancer, Breast Lesions of Uncertain Malignant Potential (B3 Lesions)
BRCA1, RASSF1A and PTEN Methylation in Breast Lesions of Uncertain Malignant Potential
This prospective interventional diagnostic study evaluates the clinical utility of methylation analysis of BRCA1, RASSF1A and PTEN genes in breast lesions of uncertain malignant potential (B3 lesions).
- Trial name
- NCT07416500
- Testing
- MS-MLPA Methylation Analysis
- Where
- Slovenia
- Volunteers
- 301 people
- Sponsor
- Institute of Oncology Ljubljana
Colorectal Neoplasms Malignant
Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread…
- Trial name
- COVID-CRC (NCT04712292)
- Testing
- Surgical procedure for confirmed or suspected colorectal cancer
- Where
- 45 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- University of Bologna
Diabetic Kidney Disease
To Improve the Ability of Early Screening and Diagnosis in Patients With Diabetic Nephropathy
This is a large-scale, multi-center, observational study. It is planned to establish a large database of 10,000 patients with type 2 diabetes mellitus to investigate the prevalence, awareness and screening rates of diabetes…
- Trial name
- NCT05047471
- Where
- 50 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Yiming Mu
Juvenile Idiopathic Arthritis
Personalized Estimates of Response and Severity Outcomes in Newly-diagnosed JIA
The PERSON-JIA Trial is a cluster-randomized trial testing the use of Shared Decision Making (SDM) with families for treatment of children with arthritis.
- Trial name
- PERSON-JIA (NCT05310799)
- Testing
- Shared Decision Making (SDM)
- Where
- Canada
- Volunteers
- 842 people
- Sponsor
- University of British Columbia
Breast Cancer
Application of Ultrasound Artificial Intelligence and Elastography in Differential Diagnosis of Breast Nodules
The application of computer-aided diagnosis (CAD) technology "S-Detect" enables qualitative and quantitative automated analysis of ultrasound images to obtain objective, repeatable and more accurate diagnostic results.
- Trial name
- NCT03887598
- Testing
- Ultrasound diagnosis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xin-Wu Cui
Intracerebral Hemorrhage
Clinical Diagnosis and Treatment of Intracerebral Hemorrhage Based on Artificial Intelligence
The purpose of this study is to test the reliability and validity of an artificial intelligence system and a related 5-score scale to predict hematoma expansion, and conduct a study cohort of intracerebral hemorrhage to screen…
- Trial name
- CATCH-AI (NCT04951570)
- Where
- China
- Volunteers
- 1,374 people
- Sponsor
- Beijing Tiantan Hospital
Stable Coronary Heart Disease
Use of Different Diagnostic Coronary Catheters Over the Radial Access - the UDDC - Radial Trial
There is no evidence from prospective randomized clinical trials regarding the performance of conventional (two-catheter-concept; TCC) versus one-catheter-concepts (OCC) for invasive coronary angiography over the radial access.
- Trial name
- UDDC (NCT02947542)
- Testing
- One-catheter concept, Standard catheter
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Hepatic Cancer, Hepatic Resection
Immunohistochemical Algorithm for the Diagnosis and Classification of Hepatocellular Carcinomas With TERT, TP53 and CTNNB1 Mutation
The presence of certain mutations in HCC, such as TERT and TP53, have a suspected or proven prognostic role in resected patients, but lack a morphological or immunophenotypic counterpart, which would allow us to define which…
- Trial name
- NCT06718153
- Testing
- Immunohistochemistry and in situ hybridisation analysis
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Prostate Cancer (Diagnosis)
Validation of a Platelet Proteomic Assay for Diagnosing and Monitoring Prostate Cancer
This is a single center study evaluating whether a new blood test based on platelet proteins rather than plasma proteins can improve detection of prostate cancer and evaluate the degree of serious disease.
- Trial name
- NCT07144228
- Testing
- HeLP TM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Malaria,Falciparum, Malaria in Pregnancy
Plasmodium Falciparum Genomic Intelligence in Mozambique
Mozambique is among the ten countries with the highest burden of malaria worldwide, with an estimated 9.3 million cases in 2018, and constitutes a core target for the World Health Organization (WHO) and the Roll Back Malaria…
- Conditions
- Malaria,Falciparum, Malaria in Pregnancy, Malaria
- Trial name
- GenMoz (NCT05306067)
- Testing
- LDH-based malaria rapid diagnostic test, Malaria rapid diagnostic test
- Where
- Mozambique
- Volunteers
- 21,848 people, healthy volunteers welcome
- Sponsor
- Centro de Investigacao em Saude de Manhica
Esophageal Cancer, Lymph Node Metastases
99m Tc-3PRGD2 SPECT/CT Imaging in the Diagnosis of Lymph Node Metastasis of Esophageal Carcinoma
The esophageal squamous cell carcinoma (ESCC) has high prevalence and mortality in China, which become a severe challenge for public health.
- Conditions
- Esophageal Cancer, Lymph Node Metastases, Diagnoses Disease
- Trial name
- NCT04504565
- Testing
- 99mTc-3PRGD2
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Coronary Artery Disease
Comparison of the HyperQ Versus Conventional Electrocardiogram (ECG) to Detect Ischemia
The purpose of the investigation is to verify the efficiency of the HyperQ™ system in detecting exercise induced ischemia, with higher specificity and sensitivity than conventional ECG Stress testing.
- Trial name
- NCT00917800
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- West German Heart Center Essen
Colorectal Cancer
Peripheral Blood Monocytes as Predictive Marker for Colorectal Cancer Diagnosis: A Comparative Study of a Stool Based Versus Blood Based Screening Test
In this prospective study, the main goal is to evaluate the strength of Monomark -a monocyte-based transcriptomic test combined to a mathematical model- in patients with a positive FIT test.
- Trial name
- MonoFIT+ (NCT03462992)
- Testing
- MonoMark
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- DNAlytics
Adenomyosis
Validation and Optimisation of Ultrasound Diagnosis of Adenomyosis
Defining ultrasound criteria for normal uterine biometry and assessing the prevalence of repeat abortions in patients with abnormalities of the uterine cavity
- Trial name
- NCT06795711
- Where
- Italy
- Volunteers
- 465 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Cancer
Cyclophosphamide and Docetaxel or Doxorubicin in Treating Women With Newly Diagnosed Breast Cancer That Can Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, docetaxel, and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00801411
- Testing
- cyclophosphamide, docetaxel, doxorubicin hydrochloride
- Where
- 2 sites in Singapore
- Volunteers
- 318 people
- Sponsor
- National Cancer Centre, Singapore
Obstructive Sleep Apnea
Clinical Evaluation of a Wearable Technology for the Diagnosis of Sleep Apnoea
This trial will aim to test a new wearable device for the diagnosis of Sleep Apnoea.
- Trial name
- NCT04028011
- Testing
- Novel Wearable device
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Acurable Ltd.
Neurodevelopmental Disorder (Diagnosis), Feeding Disorder
Feeding Disorders in Children
Pediatric Feeding Disorders (PFDs) are conditions characterized by persistent difficulties in food intake, commonly manifesting as food selectivity, food refusal, and dysfunctional mealtime behaviors.
- Conditions
- Neurodevelopmental Disorder (Diagnosis), Feeding Disorder, ARFID
- Trial name
- FEEDING (NCT07431671)
- Testing
- Interdisciplinary intervention, Standard rehabilitation program
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS San Raffaele Roma
Vertigo
Diagnostic Aid for Vertigo Patients
Consultations for vertigo in general practice are difficult, primarily due to practitioners' lack of experience. Patient referrals can be inaccurate, leading to missed opportunities or misuse of resources.
- Trial name
- ADPV (NCT07299487)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19
Vital Sensor Monitors for CV19 Detection
This study will monitor physical bio-markers such as heart rate, respiratory rate, and temperature to detect potential COVID-19 infections.
- Trial name
- NCT04635787
- Testing
- ANNE One
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Northwestern University
Deep Vein Thrombosis (DVT)
Improving Emergency Department Testing for Deep Vein Thrombosis
This observational study will use a new way to test for deep vein thrombosis (DVT) of the leg. A DVT is a blood clot in the leg and is a medical problem that can cause swelling, pain, and redness.
- Trial name
- NCT06195787
- Where
- Canada
- Volunteers
- 458 people
- Sponsor
- Dr. Kerstin de Wit