Clinical trials: Diagnostic Screening Programs
Artificial Intelligence, Diagnostic Imaging
Real-time Artificial Intelligence System for Detecting Multiple Ocular Fundus Lesions by Ultra-widefield Fundus Imaging
This prospective multicenter study will evaluate the efficacy of a real-time artificial intelligence system for detecting multiple ocular fundus lesions by ultra-widefield fundus imaging in real-world settings.
- Conditions
- Artificial Intelligence, Diagnostic Imaging, Abnormality of the Fundus, Diagnostic Screening Programs
- Trial name
- NCT04859634
- Testing
- Taking an ultra-widefield fundus image
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Satisfaction, Patient
Shared Decision Making and Satisfaction With the Diagnostic-therapeutic Process in the Shared Decision Making and Satisfaction With Colorectal Cancer Screening. The CyDESA Study
A cross sectional multicenter study (3 centers) to know the participation in decision making and the experience and satisfaction of participants with a positive immunological fecal test (FIT) result in relation to the screening…
- Trial name
- CyDESA (NCT04610086)
- Where
- Spain
- Volunteers
- 846 people
- Sponsor
- Corporacion Parc Tauli
Atrial Fibrillation
RedStroke - Reducing Europe's Stroke Incidence
In the RedStroke study, the effect of a smartphone application in detecting Atrial Fibrillation (AF) will be assessed in a double-blind randomised controlled multicenter trial.
- Trial name
- RedStroke (NCT04108884)
- Testing
- App measurement, 14 day Holter ECG
- Where
- 7 sites in Germany, Greece and 4 more
- Volunteers
- 1,019 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiovascular Disease (CVD), Cardiovascular Risk Factor
Women's Advanced Risk-assessment in Manitoba
The main objective of this study is to test the ability of novel cardiovascular disease (CVD) prognostic tools to identify women at risk for future CVD. We plan to establish a cardiovascular health screening program at the St.
- Conditions
- Cardiovascular Disease (CVD), Cardiovascular Risk Factor, Vascular Stiffness
- Trial name
- WARM (NCT03938155)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- St. Boniface Hospital
Solid Tumor Cancer
A Study of a Distress Screening and Referral Program in People With Recently Diagnosed Cancer
It is recommended that cancer centers screen patients for distress and refer them to mental health services when their distress levels reach a certain level.
- Trial name
- NCT07117461
- Testing
- NCCN Distress Thermometer
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Colorectal Neoplasms
Evaluation of a Model for the Early Diagnosis of Colorectal Cancer by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA to the Community Colorectal Cancer Screening Program
The incidence rate and mortality of colorectal cancer are increasing year by year. Most colorectal cancer develops from colorectal adenoma and is a disease that can be prevented and controlled.
- Trial name
- METHOD-3 (NCT05638243)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Congenital Heart Disease in Pregnancy, Prenatal Diagnosis
The National Program for the Improvement of Management of Fetal Congenital Heart Disease in China
To investigate and evaluate the capacity of prenatal screening, diagnosis and counseling of congenital heart disease in medical institutions in China, in order to understand the current status and existing problems of prenatal…
- Conditions
- Congenital Heart Disease in Pregnancy, Prenatal Diagnosis, Fetal Echocardiography
- Trial name
- NCT05940363
- Testing
- Improvement on Prenatal Screening and Treatment Capabilities for Congenital Heart Disease with a Comprehensive Diagnosis and Treatment Program Incorporating New Technologies
- Volunteers
- 9,000 people
- Sponsor
- Beijing Anzhen Hospital
Breast Cancer, Benign Breast Disease
Evaluating Scaleup of an Adapted Breast Cancer Early Diagnosis Program in Rwanda
Breast cancer incidence is increasing in low- and middle-income countries (LMICs) and breast cancer mortality is high in these regions largely due to late stage diagnoses.
- Conditions
- Breast Cancer, Benign Breast Disease, Cervix Cancer
- Trial name
- NCT05364138
- Where
- Rwanda
- Volunteers
- 2,357 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Neurology, Aromatic Amino Acid Decarboxylase Deficiency
Newborn Screening and Early Diagnosis of AADC Deficiency in the Ligurian Population
Aromatic L-amino acid decarboxylase deficiency (AADC-D) is a rare genetic disorder that affects the production of neurotransmitters in the brain and can cause severe neurological and developmental problems.
- Conditions
- Neurology, Aromatic Amino Acid Decarboxylase Deficiency, Pediatric Neurological Disorder
- Trial name
- NBS3OMD22 (NCT07877714)
- Where
- 10 sites in Italy
- Volunteers
- 16,000 people
- Sponsor
- Istituto Giannina Gaslini
Arteriovenous Graft Stenosis, Arteriovenous Graft Thrombosis
Optimal Screening Program in Detecting Stenosis and Predicting Thrombosis in Hemodialysis Graft
A well-functioning vascular access is essential for providing adequate life-sustaining treatment in patients with end stage renal disease on maintenance hemodialysis.
- Trial name
- NCT03839264
- Testing
- Graft stenosis and thrombosis
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Atrial Fibrillation
Hong Kong Outpatient AF Screening Using Single-lead ECG Device
Stroke is a leading cause of mortality, morbidity and rising healthcare cost worldwide. In 'real-world' practice, AF is often diagnosed too late at time of stroke and detection can be difficult because AF may be present without…
- Trial name
- NCT02409654
- Testing
- Patient education, Routine care
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Follow-Up Study for Men Diagnosed With Prostate Cancer Through Participation in a Prostate Specific Antigen Screening Program
There is controversy concerning the preferred treatment for men with localized prostate cancer with regard to the relative effectiveness of different treatments in controlling the cancer and how different treatments affect the…
- Trial name
- NCT00035217
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Fabry Disease
Fabry Disease in Cerebrovascular Disease
Fabry disease is an X-linked disorder of glycosphingolipid catabolism caused by a deficiency of the enzyme α-galactosidase A (α-Gal A), which leads to a progressive accumulation of globotriaosylceramide (Gb-3) in plasma and…
- Trial name
- NCT02859363
- Testing
- 26 common Fabry mutation types in Taiwan
- Where
- Taiwan
- Volunteers
- 700 people
- Sponsor
- Chang Gung Memorial Hospital
Cardiovascular Diseases, Diabetes Mellitus Type 2
"Screening for Change: Early Risk Detection and Integrated Prevention for Diabetes and Cardiovascular Diseases in the Marche Region"
This study aims to test the feasibility of a new systematic screening program to allow the early detection of individuals aged 50 years at risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs) in the resident…
- Trial name
- JAC_AST (NCT07344701)
- Testing
- Screening program
- Where
- 2 sites in Italy
- Volunteers
- 2,951 people
- Sponsor
- Marche Region Regional Health Agency
Colorectal Cancer
Participation and Detection Rate of Screening CT Colonography and Screening Sigmoidoscopy
The objectives of this multicenter, randomized trial is to assess the participation rate achievable through two different screening strategies (Computed Tomographic Colonography-CTC and sigmoidoscopy-FS), to compare detection…
- Trial name
- Proteus (NCT01739608)
- Testing
- Invitation to screening
- Where
- Italy
- Volunteers
- 40,945 people
- Sponsor
- Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte
Diabetes Mellitus, Type 2, Pre Diabetes
Increasing Uptake of EHR-enabled Population Health Outreach Strategies to Improve Diabetes Screening
The study team's central hypothesis is that the Parkland Diabetes Detection Program (PDDP) screening invitations targeted by race/ethnicity with culturally concordant messaging and tailored by glycemic risk (known PDM vs.
- Trial name
- NCT05730582
- Testing
- Parkland Diabetes Detection Program (PDDP) Screening Invitation
- Where
- United States
- Volunteers
- 500,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Plasmodium Falciparum Malaria
Mass Screening and Treatment for Reduction of Falciparum Malaria
In this project, the investigators aim at an operational research deployment of Ultrasensitive Rapid Diagnostic Test (URDT) -based Mass Screening and Treatment (MSAT) in the Malaria Elimination Task Force (METF) elimination…
- Trial name
- MSAT (NCT04093765)
- Testing
- Ultrasensitive Rapid Diagnostic Test (URDT), Antimalarials
- Where
- Thailand
- Volunteers
- 5,542 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV/AIDS, Cancer
IMPACt of an Enhanced Screening Program on the Detection of Non-AIDS NEOplasms in HIV Patients
Introduction: The incidence of malignancies is higher in the HIV-infected population than in the general population, and it is already one of the leading causes of death in people living with the virus.
- Trial name
- IMPACNEO (NCT04735445)
- Testing
- Digital rectal exam and / or anal cytology (day 1 and after 36 months), Semestral digital rectal exam and / or anal cytology if abnormal → ANOSCOPY with biopsy, Cervical cytology and cervical sample for HPV detection (day 1 and after 36 months)
- Where
- Spain
- Volunteers
- 4,638 people
- Sponsor
- Felix Gutierrez
Ovarian Diseases, Ovarian Neoplasms
Cancer Screening Program for Women at High Risk for Developing Ovarian Cancer
The main purpose of this program is to see whether periodically measuring CA-125 (tumor marker) levels in the blood and undergoing transvaginal ultrasounds over time will be effective in the early detection of ovarian cancer.
- Trial name
- OCEDP (NCT01292733)
- Testing
- Laboratory Tumor Marker Analysis, Transvaginal Ultrasound, Health Status Questionnaire
- Where
- United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
SARS-CoV-2 Infection, COVID-19
Evaluation of a Screening Program for SARS-CoV-2 Infection in the General Population Based on the Use of New Detection Approaches or for Diagnostic Orientation on Saliva
The investigators hypothesize that detection of SARS-CoV2 on saliva samples will increase the performance of the screening program compared to the reference strategy (RT-PCR on a nasopharyngeal swab).
- Trial name
- SALICOV (NCT04578509)
- Testing
- Nasopharyngeal swab, Saliva sample, axillary sweat sample
- Where
- France
- Volunteers
- 5,197 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris