Clinical trials: Diagnostic Strategies
Coronary Artery Stenosis
Multivessel Disease Diagnosed at the Time of PPCI for STEMI: Complete Revascularization Versus Conservative Strategy.
The aim of the study is to find the optimal management of patients with acute myocardial infarction with ST elevations treated by primary PCI who have at least one significant stenosis of non-culprit coronary artery.
- Trial name
- Prague-13 (NCT01332591)
- Testing
- Percutaneous coronary intervention
- Where
- Czechia
- Volunteers
- 213 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Deep Vein Thrombosis
Systematic Machine Learning Algorithm for Rapid Thrombosis Detection
The goal of this clinical trial is to compare the use of a machine learning-based algorithm and point-of-care D-dimer to laboratory D-dimer and compression ultrasound to exclude deep vein thrombosis in the under extremities in…
- Trial name
- DVT-SMART (NCT06842446)
- Testing
- POC D-dimer, POC ultrasound, Machine learning model
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Ostfold Hospital Trust
Multiple Myeloma, Newly Diagnosed
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
This is a prospective, single-center, clinical study to evaluate the efficacy and safety of a fully immunotherapy-based strategy guided by MRD-driven dynamic risk stratification in transplant-ineligible patients with newly…
- Trial name
- MAGIC-TIEMM (NCT07106736)
- Testing
- BCMA CAR-T, GPRC5D/CD3 BiTEs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Quality of Health Care, Pulmonary Embolism
Strategies for Suspected Pulmonary Embolism in Emergency Departments
Aims: 1) To evaluate the effectiveness of two interventions aimed at improving the management of patients with suspected pulmonary embolism: Written guidelines and Computer-Assisted Decision Support (CADS).
- Trial name
- NCT00188032
- Testing
- Computer-Assisted diagnostic Decision Support, written diagnostic guidelines, electronic therapeutic reminders
- Where
- 20 sites in France
- Volunteers
- 1,331 people
- Sponsor
- University Hospital, Angers
Any Chronic, Non-traumatic Orthopedic Condition
Testing an AI Large Language Model Tool for Cognitive Debiasing in Musculoskeletal Care
The goal of this clinical trial is to find out whether using an artificial intelligence (AI) tool called a Large Language Model (LLM) can help patients think more clearly about their symptoms and improve their trust and…
- Trial name
- NCT07022769
- Testing
- LLM-facilitated cognitive debiasing aid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Pancreatic
Tumor Exosome Liquid Biopsy Strategy to Diagnose Pancreatic Cancer
This is an observational study of patients diagnosed with pancreatic cancer by pathology, with a control group of patients with pathology suggestive of benign pancreatic lesions and normal subjects, and the diagnostic ability of…
- Trial name
- NCT06108531
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Non-Alcoholic Fatty Liver Disease, Chronic Liver Disease
Combination Diagnostic Strategies in NAFLD
Serial combination of biological and elastography tests is accurate to diagnosing advanced fibrosis in non-alcoholic fatty liver disease (NAFLD) patients.
- Trial name
- CombinationSSI (NCT04384159)
- Volunteers
- 577 people
- Sponsor
- University Hospital, Montpellier
Pulmonary Embolism
Modified Strategy to Safely Rule Out Pulmonary Embolism in the Emergency Department
Because a missed PE could be potentially lethal, several researches reported that PE is both overinvestigated and overdiagnosed.
- Trial name
- MODIGLIA-NI (NCT04032769)
- Testing
- MODS (MOdified Diagnostic Strategy)
- Where
- 2 sites in France, Spain
- Volunteers
- 1,414 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polyp Colorectal
An Integrated Management Pathway for Complex Colorectal Polyps
The purpose of this study is to evaluate the impact of implementing an integrated clinical care pathway for the diagnosis, referral, evaluation and treatment of large complex colorectal polyps on clinical outcomes
- Trial name
- NCT04576780
- Testing
- Integrated Large Complex Polyp Referral Pathway
- Volunteers
- 400 people
- Sponsor
- Unity Health Toronto
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Neuro-Degenerative Disease
Contribution of New Generation Oxford Nanopore-type High-throughput Sequencing in the Diagnostic Strategy of Neurogenetic Diseases.
Since 2012, NGS sequencing of long fragments or long reads has developed in various fields of research and today presents itself as a very promising alternative solution in the analysis of repeat amplifications.
- Trial name
- NEURONGS3 (NCT04621422)
- Testing
- Subject carrying an amplification of nucleotide repeats in one of the following 9 genes FMR1, DMPK, ZNF9, SCA2, JPH3, HD, FXN, C9ORF72, RFC1
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Atlantoaxial Dislocation, Treatment
A Study on Diagnosis and Treatment Strategies for Atlantoaxial Dislocation
The most effective treatment for atlantoaxial dislocation is surgical treatment, with the principle of achieving reduction, reconstruction, and fusion of the atlantoaxial joint.
- Conditions
- Atlantoaxial Dislocation, Treatment, Diagnostic
- Trial name
- NCT06233539
- Testing
- Observational research without intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Peking University Third Hospital
Helicobacter Pylori Infection
New Strategy for the Detection and Treatment of Helicobacter Pylori Infections in Primary Care Guided by a Non-invasive PCR in Stool
In France, every year 1 million people are explored for Helicobacter pylori infection and 200,000 receive eradication treatment.
- Trial name
- HEPYPRIM (NCT05495854)
- Testing
- PCR test in the stool, Hp serology and gastroscopy
- Where
- 13 sites in France
- Volunteers
- 245 people
- Sponsor
- Poitiers University Hospital
Asthma
Strategies to Improve Asthma and Treatment of Asthma in Canadians
Our study will enroll 644 randomly-selected Canadians who have been diagnosed with asthma by a physician within the previous five years. It will be determined what diagnostic tests were initially performed to make this diagnosis.
- Trial name
- NCT01525381
- Where
- Canada
- Volunteers
- 701 people
- Sponsor
- Ottawa Hospital Research Institute
Triple Negative Breast Cancer
Personalized Cancer Vaccine (PCV) Strategy in Triple Negative Breast Cancer Patients
This is a phase 1 clinical trial to evaluate the safety, feasibility and immunogenicity of a personalized cancer vaccine (PCV) strategy with or without CD8-selective IL-2 mutein fusion protein in patients with triple negative…
- Trial name
- NCT07300475
- Testing
- Paclitaxel, Carboplatin, Pembrolizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease, Coronary Artery Disease (Left Main)
µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions
Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Obstructive Coronary Artery Disease, Stent Implantation
- Trial name
- NCT07116083
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Shanghai Zhongshan Hospital
Nonalcoholic Steatohepatitis, Type 2 Diabetes
Clinical Outcomes From Enhanced SCREENing Strategies for NASH in Type 2 Diabetes (SCREEN NASH T2D)
The study is stratified cluster randomized trial. The study population will include adults with T2D and presumed NASH.
- Trial name
- NCT05029583
- Testing
- routine screening, physician-driven screening
- Where
- Canada
- Volunteers
- 5,000 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Air Leak From Lung
Air Leak Detection and Treatment
Developing a methodology to detect, quantify and treat air leaks intraoperatively using a bio-adhesive, to thereby reduce postoperative surgical complications, morbidity, and length of stay for patients undergoing pulmonary…
- Trial name
- CT0128 (NCT05854654)
- Testing
- Air Leaks
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Critical Illness
Physical Therapist Inter-Rater Reliability in Neuro-Muscle Ultrasound in Critically Ill Patients
The goal of this observational study is to evaluate the feasibility and inter-rater reliability of muscle and peripheral nerve ultrasound for the early detection of ICU-acquired weakness (ICU-AW) in critically ill patients.
- Trial name
- NMusICU-R (NCT07032870)
- Where
- Chile
- Volunteers
- 37 people
- Sponsor
- University of Chile
HIV Infections
Piloting At-birth Point of Care HIV Testing Strategies in Kenya
Innovative strategies to expedite HIV diagnosis among exposed infants, including at-birth testing and two portable point-of-care (POC) diagnostic systems, will be piloted using an implementation framework.
- Trial name
- NCT03435887
- Testing
- Alere q HIV-1/2 Detect for point of care infant testing, GeneXpert HIV-1 Qual for point of care infant testing, HIV DNA PCR testing (Standard of Care)
- Where
- 5 sites in United States, Kenya
- Volunteers
- 1,999 people
- Sponsor
- University of Kansas Medical Center