Clinical trials: Diagnostic Tests
Giant Cell Arteritis (GCA)
Performance of a Fast-track Pathway for Giant Cell Arteritis Diagnosis
Giant cell arteritis is a vasculitis, i.e. inflammation of the artery walls, which generally affects people over the age of 50. Diagnosis can be long and difficult, as the clinical signs are not specific (headache, pain in the…
- Trial name
- QuickDx-GCA (NCT06742671)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Breast Neoplasm Female
Digital Delivery of Information About Genetic Testing for Breast Cancer
BRCA-DIRECT is a pragmatic, randomised, non-inferiority evaluation that aims to evaluate whether digital delivery of pre-test information for BRCA-testing in breast cancer patients is non-inferior to current standard practice of…
- Trial name
- BRCA-DIRECT (NCT04842799)
- Testing
- Digital Delivery of Pre-Genetic Testing Information via the BRCA-DIRECT Platform, Digital Delivery of Genetic Test Results via the BRCA-DIRECT Platform
- Where
- 5 sites in United Kingdom
- Volunteers
- 1,140 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Rheumatoid Arthritis, Tuberculosis
Comparison of the Tuberculin Skin Test (TST) and QuantiFERON ®-TB Gold Test (QFT-G) In Patients With Rheumatoid Arthritis Being Considered for Anti-TNF-Alpha Therapy
This research will help doctors interested in the usefulness of a new test to discover hidden tuberculosis infections in patients diagnosed with rheumatoid arthritis (RA). This new test is called Quantiferon-Gold (QFT-G).
- Trial name
- NCT00925249
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Renal Cell Carcinoma
Study Testing the Biologic Activity and Safety of an Immunotherapeutic in Patients With Newly Diagnosed Stage IV Kidney Cancer
The purpose of this trial is to examine the safety, feasibility, immunological response, and clinical antitumor activity of multiple administrations of dendritic cell Immunotherapeutic to patients with newly diagnosed with…
- Trial name
- NCT00272649
- Testing
- AGS-003
- Where
- 10 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- Argos Therapeutics
Sickle Cell Anemia
The Montreal Cognitive Assessment.Test in Adults With Sickle Cell Disease
This study will assess the performances of the Montreal Cognitive Assessment (MoCA) to screen for cognitive impairment in adults with sickle cell anemia.
- Trial name
- EvaCAD (NCT05347043)
- Testing
- Montreal cognitive assessment
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemodialysis Complication, Hypotension During Dialysis
Evaluation of Total Blood Volume Measurement During Dialysis on the Incidence of Intradialytic Hypotension
Establishing the euvolemic state in hemodialysis patients -the so called "dry weight"- is an important clinical conundrum in every nephrologist's daily practice.
- Conditions
- Hemodialysis Complication, Hypotension During Dialysis, Diagnostic Tests
- Trial name
- NCT05872984
- Testing
- adjustment of dry weight based on absolute blood volume measurement
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- HagaZiekenhuis
Copy Number Abnormality, Prenatal Diagnosis
Technology Development for Noninvasive Prenatal Genetic Diagnosis Using Whole Fetal Cells From Maternal Peripheral Blood
Amniocentesis (amnio) and chorionic villus sampling (CVS) can reliably detect many smaller DNA/genetic abnormalities that cannot be reliably diagnosed by cell-free noninvasive prenatal testing (NIPT) that is in widespread use.
- Conditions
- Copy Number Abnormality, Prenatal Diagnosis, Genetic Disease
- Trial name
- NCT04285814
- Testing
- Whole Fetal Cell (WFC) Testing
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Columbia University
COPD
Portable Oxygen Concentrator to Improve Quality of Life in Chronic Obstructive Pulmonary Disease
Evaluate subjects in an prospective observational study Subjects will be administered scientifically validated questionnaires Determine the affect of the Portable Oxygen Concentrator (POC) on improvements in: 1.
- Trial name
- NCT01948544
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- StratiHealth
Attention Deficit Hyperactivity Disorder (ADHD)
Assessing QbTest Utility in ADHD: A Randomised Controlled Trial
Attention Deficit/Hyperactivity Disorder (ADHD)is one of the most common mental health disorders of childhood. Children with ADHD often have poor attention, are restless and hyperactive and show impulsive behaviour.
- Trial name
- AQUA2 (NCT02209116)
- Testing
- Qb Test
- Where
- 9 sites in United Kingdom
- Volunteers
- 267 people
- Sponsor
- University of Nottingham
Placenta Accreta Spectrum
Diagnostic Accuracy of Placental Thickness in Lower Uterine Segment Measured By Ultrasound in Prediction of Placenta Accreta Spectrum in Patients With Placenta Previa. A Diagnostic Test Accuracy Study
Current prenatal diagnosis of placenta accrete spectrum disorders relies on subjective individual interpretations of visual sonographic findings on grayscale and color Doppler imaging.
- Trial name
- NCT05500404
- Testing
- Ultrasound measurment of placental thickness
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams Maternity Hospital
Non-small Cell Lung Cancer
Resistance & Activating Mutations Diagnosed Among NSCLC Community Dwelling EGFR Mutation Positive Patients
The study is being done to determine if non-invasive testing (urine and plasma testing) is as effective as tissue testing in identifying epidermal growth factor receptor (EGFR) T790M mutation status.
- Trial name
- RADIANCE (NCT03137264)
- Testing
- Other
- Where
- 23 sites in United States, Canada
- Volunteers
- 44 people
- Sponsor
- AstraZeneca
Bile Leakage
Diagnostic Role of the "White Test" With Lipidic Solution in the Early Intraoperative Identification of Open Bile Ducts for the Prevention of Bile Leakage After Liver Resection (BiLe -Trial)
Bile leakage (BL) is the most frequent complication after liver resection. This study is to investigate the role of intraoperative administration of SMOFlipid 20% (fat emulsion which allows intraoperative identification of open…
- Trial name
- BiLe (NCT04523701)
- Testing
- "white" test" (= the administration of SMOFlipid retrograde through the cystic duct)
- Where
- 5 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Giulia Manzini
Streptococcus Group B
Development and Optimization of a GBS Diagnostic Test
The purpose of this clinical study is to develop an easily performed test to detect Group B Streptococcus (GBS) in pregnant women at the time of delivery, which would allow health care providers to make an accurate and rapid…
- Trial name
- NCT00322829
- Where
- Canada
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Laval University
Dengue Fever
Evaluation Study of Dengue RDTs
RT-PCR and virus isolation are considered gold standard for diagnosis of Dengue from blood during first few days of infection. Serological methods such as enzyme-linked immunosorbent assays (ELISA), confirms the presence of a…
- Trial name
- NCT05580731
- Testing
- Diagnostic test: 5 different Rapid diagnostic test and Reference tests
- Where
- Pakistan
- Volunteers
- 430 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Preeclampsia
CercaTest™ Red Urine Test for Predicting Preeclampsia
The goal of this observational study is to predict preeclampsia in pregnant women aged 18 years or older with a singleton pregnancy at 20 or more weeks of gestation who present with suspected signs or symptoms of preeclampsia.
- Trial name
- PRE-CERCA (NCT07625501)
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Pediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)
Testing Pediatric Rheumatology Diagnostic Decision Support in Clinical Use
Boston Children's Hospital resources include SimulConsult which is a decision support tool available for use of BCH provider through the library portal.
- Trial name
- NCT03501667
- Testing
- Use of decision support tool, Use of UpToDate
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Boston Children's Hospital
Skin Diseases
Evaluation of CL Detect™ Rapid Test to Detect Cutaneous Leishmaniasis
This study is a single-site trial assessing the specificity of CL Detect™ Rapid Test versus the gold standard for Leishmania diagnosis in the US which is microscopic identification of Leishmania amastigotes in a stained lesion…
- Trial name
- NCT01865032
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- U.S. Army Medical Research and Development Command
Potassium Measurement
GAMMA Study: Patient Self-testing of Capillary Blood Potassium: A Validation Study and Measurement Performance in Patients.
Multicentre, open, prospective and interventional study investigating the CardioRenal device in capillary blood of patients.It will be conducted at multiple investigational sites.
- Trial name
- NCT05975632
- Testing
- Device: Self testing Potassium device
- Where
- 6 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- CardioRenal
Tuberculosis
Prevalence of Latent Tuberculosis (TB) Infection Diagnosed by Interferon-gamma Release Assay and Tuberculin Skin Tests in Patients With Old Healed TB
We easily regard nodules and fibrosis in upper lobes of lung as TB sequelae. The aim of this study is to confirm the prevalence of latent TB infection diagnosed by interferon-gamma release assay and tuberculin skin tests in…
- Trial name
- NCT01099098
- Where
- South Korea
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Influenza, Respiratory Syncytial Viruses
TGV:Use of the Quick Diagnostic Test of the Influenza and the Infection With RSV by the Paediatric Emergency Unit
The aim of this study is to evaluate the impact of the use of a quick diagnostic test of infection with RSV and influenza virus on the assumption of clinical responsibility of the children consulting at the Paediatric Emergency…
- Trial name
- NCT00263900
- Testing
- RSV respi-strip and Quick-vue influenza
- Where
- 4 sites in France
- Volunteers
- 377 people
- Sponsor
- University Hospital, Rouen