Clinical trials: Diagnostics
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
The purpose of this study is to validate results from a related trial (NCT01791257) and to compare the profile of microRNA in blood from patients suffering subarachnoid hemorrhage with and without systemic complications.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Acute Lung Injury, Cardiac Dysfunction
- Trial name
- NCT02320539
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neurogenic Bladder Disorder, Lower Urinary Tract Disorder
Rapid UTI Diagnostics in Lower Urinary Tract Dysfunction Among Catheter Users
Patients who seek care through MedStar National Rehab Hospital's clinic believing they have a UTI will be enrolled in this trial.
- Conditions
- Neurogenic Bladder Disorder, Lower Urinary Tract Disorder, Urinary Tract Infection (Diagnosis)
- Trial name
- NCT07784829
- Testing
- urine Resazurin Reduction Ratio, USQNB
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Heart Failure, Infection
Improve Management of Heart Failure With Procalcitonin
Patients presenting to the Emergency Department with shortness of breath and (suspected) heart failure will be screened and randomized to either a standard of care or a procalcitonin-guided arm.
- Trial name
- IMPACT-EU (NCT02392689)
- Testing
- Procalcitonin
- Where
- 15 sites in Denmark, Germany and 2 more
- Volunteers
- 759 people
- Sponsor
- Brahms AG
Sepsis, Septicemia
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
We propose to develop novel diagnostic tests for severe sepsis and community acquired pneumonia (CAP). This program, entitled Community Acquired Pneumonia \& Sepsis Outcome Diagnostics (CAPSOD), is a multidisciplinary…
- Conditions
- Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic
- Trial name
- NCT00258869
- Where
- 3 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- National Center for Genome Resources
Atrial Fibrillation, Arrhythmias, Cardiac
Telemetric Arrhythmia and Syncope Diagnosis - Evaluation of Arrhythmia Treatment Efficacy
The purpose of this study is to assess efficacy of prolonged Full Disclosure ECG monitoring and signal analysis using advanced GSM telemetric technology to prescribe the most appropriate treatment of arrhythmia.
- Trial name
- TELEMARC 4 (NCT01265303)
- Testing
- Prolonged telemetric Full Disclosure ECG recording.
- Where
- 3 sites in Belgium, Poland
- Volunteers
- 360 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronavirus Infection, COVID-19
Facilitating AcceLerated Clinical Validation Of Novel Diagnostics for COVID-19 (FALCON-C19)
The United Kingdom and wider world is in the midst of the 2019 novel coronavirus (SARS-CoV-2) pandemic. Accurate diagnosis of infection, identification of immunity and monitoring the clinical progression of infection are of…
- Trial name
- FALCON-C19 (NCT04408170)
- Testing
- Point-of-care test for SARS-CoV-2
- Where
- 15 sites in United Kingdom
- Volunteers
- 8,380 people
- Sponsor
- Manchester University NHS Foundation Trust
Heart Failure
Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate…
- Trial name
- Alberta HEART (NCT02052804)
- Where
- 2 sites in Canada
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Coronavirus Infections, Pneumonia
Magnetic Resonance Imaging to Detect Signs of Viral Pneumonia in Patients With Coronavirus Infection.
Since the onset of the COVID-19 pandemic, the importance of chest computed tomography (CT) in detecting signs of viral pneumonia has become clear from the literature.
- Trial name
- NCT04424355
- Testing
- Chest MRI
- Where
- Russia
- Volunteers
- 25 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Hospitalization, All Conditions
New Approaches for Evaluating the Interchangeability of Reference Materials and Quality Controls (COMET-MPL)
Medical biology tests are essential to clinical decision-making. The European Regulation on in vitro diagnostic medical devices (EU/2017/746) requires metrological traceability of the values assigned to calibrators and quality…
- Trial name
- COMET-MPL (NCT07173114)
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Brain Metastases
ASL in Brain Metastasis MRI Following Gamma Knife Treatment
Arterial spin labeling (ASL) is a non-invasive MRI technique that could help the radiologists to distinguish brain metastasis progression versus radionecrosis following gamma-knife treatment.
- Trial name
- GK-ASL (NCT04833335)
- Testing
- MRI perfusion sequence
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis
Evaluation and Demonstration of New Tuberculosis Diagnostics for Indonesia
The goal of this cluster-randomised controlled trial (CRCT) is to learn whether the use of new non-sputum-based diagnostic tests and other intervention components for tuberculosis (TB) diagnosis in healthcare facilities (HCF) can…
- Trial name
- EVIDENT (NCT07293455)
- Testing
- nPOC Testing Intervention Package
- Where
- Indonesia
- Volunteers
- 40,000 people
- Sponsor
- Universitas Padjadjaran
Anal Fistula
3D Endoanal Ultrasound and Anal Fistula
The study aims to evaluate the use of 3D endoanal ultrasound in preoperative management of anal fistula disease.
- Trial name
- UFU (NCT03937752)
- Testing
- 3D endodanal ultrasound
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane
COPD Exacerbation
Ferroptosis in Patients With COPD COPD With/Without Risk of Cardiovascular Events. Pathophysiological Implications, Diagnostics and Prognoses. FerrEPOC Study.
Iron metabolism is related to several biochemical and functional factors that have a mayor impact in chronic obstructive pulmonary disease (COPD) such as hypoxia, hypercapnia, oxidative stress, chronic inflammation, cellular…
- Trial name
- FerrEPOC (NCT06102993)
- Testing
- Non-interventional study
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Hospital Universitario Marqués de Valdecilla
Liver Cancer, Hepatocellular Carcinoma
Novel Molecular Spectrometric Biomarkers in Blood Plasma as an Early Diagnostic Tool in HCC
Due to providing valuable clinical information while being minimally invasive, blood-based testing will most likely be a prerequisite for future large-scale screening of high-risk populations.
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Cirrhosis, Liver
- Trial name
- NCT04221347
- Testing
- blood sampling
- Where
- Czechia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Military University Hospital, Prague
Lung Cancer
Screening for High Frequency Malignant Disease
The SHIELD (Screening for High Frequency Malignant Disease) study is a prospective, observational, multi-site basket design trial without randomization.
- Trial name
- SHIELD (NCT05117840)
- Testing
- Low-dose CT scan
- Where
- 143 sites in United States, France and 1 more
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Guardant Health, Inc.
Cancer
Glasgow Low-dose CT and AI-based Diagnostics to Case Find Lung Cancer and Other Cardio-respiratory Long-term Conditions - Feasibility Study
Lung cancer is one of the most common and serious cancers in Scotland and is often diagnosed at a late stage. Early detection is crucial to improving survival rates.
- Trial name
- GALACTIC-1 (NCT07372508)
- Testing
- Low dose Chest CT
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- NHS Greater Glasgow and Clyde
Tuberculosis, HIV
Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama
Tuberculosis (TB) is one opportunistic infection often seen in HIV individuals. In 2013, there were an estimated 31,800 HIV-TB co-infection cases and 6,100 HIV-related deaths due to TB in the Americas.
- Conditions
- Tuberculosis, HIV, Histoplasmosis
- Trial name
- NCT02911740
- Testing
- Urine LAM Ag test
- Sponsor
- University of Florida
Symptomatic Epilepsy
Placebo Optimization of the Presurgical Long-term Video-EEG Monitoring
The notion of genuine placebo effects on epileptic seizure events (i.e., effects beyond methodological study artifacts) is incompatible with the standard model of epilepsy seizure genesis.
- Trial name
- OPERA (NCT06383689)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bonn
Fabry Disease, Fabry Disease, Cardiac Variant
Fabry Disease in High-risk Patients With Left Ventricular Hypertrophy: Prevalence and Implementation of a Clinical Score
This study aims to evaluate the prevalence of Fabry Disease (FD) among a cohort of high risk patients with left ventricular hypertrophy (LVH) presenting at the University Hospital Würzburg over the last 20 years.
- Conditions
- Fabry Disease, Fabry Disease, Cardiac Variant, Lysosomal Storage Diseases, HCM - Hypertrophic Cardiomyopathy
- Trial name
- FAPREV-HCM (NCT04943991)
- Testing
- blood sampling (alpha-Galactosidase & LysoGb3)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Wuerzburg University Hospital
Arrhythmias, Cardiac
Full Early Atrial Diagnostics in Single Chamber ICD Patients Using the DX Lead and Home Monitoring in Brazil.
To demonstrate the value and benefits of BIOTRONIK's exclusive DX technology in assessing the incidence of supraventricular arrhythmias, mainly atrial fibrillation (AF), in patients with an indication for single chamber ICDs.
- Trial name
- SAFE-DX-Home (NCT04869527)
- Testing
- BIOTRONIK ICDs with DX Technology
- Where
- 2 sites in Brazil
- Volunteers
- 56 people
- Sponsor
- Biotronik SE & Co. KG