Clinical trials: Dialysis; Complications
End Stage Renal Disease
Protein-Bound Uremic Retention Solutes in Long Nocturnal Hemodialysis
Although remarkable progress has been made, chronic kidney disease still poses a major burden on both individual patients, as well as on society as a whole.
- Trial name
- NCT00417105
- Testing
- hemodialysis
- Where
- 4 sites in Australia, Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
End Stage Renal Disease, Inflammation
Evaluation of Biocompatibility and Performances of 4 Dialyzers in Different Mode Treatments
Prospective multicenter randomized cross-over study Number of patients : 32 (8 patients per group) Obtain objectives data to advise each hemodialyzer according to dialysis treatment and patient profile.
- Trial name
- BIOMODAL (NCT03262272)
- Testing
- VIE A Hemodialyzer, Rexsys 27H hemodialyzer, Leoceed 21HX hemodialyzer
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Hemotech
Chronic Kidney Disease, Chronic Renal Disease
Comparative Effects Of Dialysate Flow Rate And Membrane Packing On The Performance Of Dialyzers Used For Hemodialysis
The purposes of this study are to determine if the performance of a dialyzer depends on how tightly the hollow fiber membranes are packed in the housing of the dialyzer (the membrane packing density) and if that dependence is a…
- Trial name
- NCT00636077
- Testing
- Polyflux HD-C4 Big, HD-C4 Small, Optiflux 160NR
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vantive Health LLC
Kidney Failure, Acute
Study to Evaluate the Safety and Efficacy of the Renal Assist Device in Patients With Acute Renal Failure
The purpose of this study is to evaluate the safety and efficacy of the RAD to determine whether the RAD is effective in reducing mortality in patients with Acute Renal Failure due to Acute Tubule Necrosis and to evaluate the…
- Trial name
- NCT00280072
- Testing
- Renal Assist Device
- Where
- 16 sites in United States
- Sponsor
- RenaMed Biologics
Kidney Failure, Chronic
A Study of LY3113593 in Healthy Participants and Participants With Chronic Kidney Disease Treated With Hemodialysis
The purpose of this study is to look at the tolerability and safety of LY3113593. Study doctors will see how safe it is and whether it produces side effects following a single injection into a vein or under the skin in healthy…
- Trial name
- NCT02144285
- Testing
- LY3113593
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Depression, Hemodialysis Complication
Depression Inventory for Maintenance Hemodialysis Patients
Depression is frequently seen among hemodialysis patients; however, it causes an impaired quality of life, a decrease in adherence to treatment, and an increase in hospitalization and mortality rate.
- Conditions
- Depression, Hemodialysis Complication, Management, Risk Behavior
- Trial name
- Depression (NCT06844890)
- Where
- Turkey (Türkiye)
- Volunteers
- 283 people
- Sponsor
- Istanbul University
Anemia, Kidney Failure
A Safety and Efficacy Study for Epoetin Alfa in Pre-dialysis Subjects.
The purpose of this study is to determine if using Eprex, to maintain hemoglobin within the normal range, will prevent or delay the progression of left ventricular mass growth.
- Conditions
- Anemia, Kidney Failure, Left Ventricular Hypertrophy
- Trial name
- NCT00364260
- Testing
- epoetin alfa
- Volunteers
- 172 people
- Sponsor
- Janssen-Ortho Inc., Canada
Chronic Kidney Disease, End-stage Renal Disease
Home-based Exercise in Chronic Kidney Disease
A home-based exercise program will be implemented in three different groups of participants: advanced chronic kidney disease, end-stage renal disease in substitutive treatment hemodialysis or peritoneal dialysis.
- Trial name
- HBCKD-BCN (NCT03621176)
- Testing
- Home-based exercise
- Where
- Spain
- Volunteers
- 57 people
- Sponsor
- Cardenal Herrera University
End Stage Renal Disease
A Research Study for Patients With End-Stage Renal Disease (ESRD)
The purpose of this study is to evaluate the ability of a treatment strategy, that includes cinacalcet for the management of secondary hyperparathyroidism, to control parathyroid hormone (PTH) compared with the standard of care.
- Trial name
- NCT00110890
- Testing
- cinacalcet, Standard of care
- Volunteers
- 552 people
- Sponsor
- Amgen
Kidney Failure, Chronic, End Stage Renal Disease, Requiring Dialysis
FREEDOM: Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements Study
Purpose The purpose of this study is to compare the economical impact and clinical parameters of short daily hemodialysis using the NxStage® System One hemodialysis device with thrice-weekly conventional in-center dialysis using…
- Trial name
- NCT00288613
- Where
- 41 sites in United States
- Volunteers
- 501 people
- Sponsor
- NxStage Medical
Peritoneal Dialysis, Exercise
Exercise Improves Gastrointestinal Function in Peritoneal Dialysis Patients
This study will investigate the impact of exercise on gastrointestinal function in peritoneal dialysis patients.
- Conditions
- Peritoneal Dialysis, Exercise, Gastrointestinal Function, Quality of Life
- Trial name
- NCT06368713
- Testing
- Exercise
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Sichuan Academy of Medical Sciences
Renal Failure
Preemptive Treatment With Grazoprevir and Elbasvir for Donor HCV Positive to Recipient HCV Negative Kidney Transplant
Proof of concept, open-label single center study for the donation of HCV positive kidneys to HCV negative patients, with preemptive, interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- NCT02945150
- Testing
- elbasvir (50mg) / grazoprevir (100mg) (fixed dose combination)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
CKD, Diabetic Kidney Disease
Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy
This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or…
- Conditions
- CKD, Diabetic Kidney Disease, Type 2 Diabetes Mellitus in Obese, Obesity
- Trial name
- RAISE-KT (NCT04741074)
- Testing
- Semaglutide 2 mg/1.5 ml (1.34 mg/ml), prefilled pen-injector for subcutaneous injection solution
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Geisinger Clinic
Chronic Renal Insufficiency
Resveratrol's Effects on Inflammation and Oxidative Stress in Chronic Kidney Disease
Inflammation and oxidative stress are common findings in patients with Chronic Kidney Disease (CKD) undergoing conservative treatment, in addition to being associated with atherosclerotic process, are related also to the…
- Trial name
- NCT02433925
- Testing
- Resveratrol
- Volunteers
- 20 people
- Sponsor
- Universidade Federal Fluminense
End Stage Renal Disease
Monitoring in Dialysis -- a Prospective, Multi-center, Single-arm, Non-randomized, Observational Study in Patients Who Are Undergoing Hemodialysis.
The primary objective of this study is to estimate the proportion of hemodialysis patients experiencing clinically significant cardiac arrhythmias over a 6-month period using continuous cardiac monitoring with an implanted…
- Trial name
- MiD (NCT01779856)
- Testing
- REVEAL Insertable Cardiac Monitor (ICM)
- Where
- 10 sites in United States, India
- Volunteers
- 81 people
- Sponsor
- Medtronic Corporate Technologies and New Ventures
End Stage Kidney Disease
Symptom Monitoring in Hemodialysis
The SMaRRT-HD trial is a cluster randomized trial of symptom monitoring with supported clinician follow-up using the SMaRRT-HD electronic patient reported outcome measure (ePROM) system versus Usual Care.
- Trial name
- SMaRRT-HD (NCT05738330)
- Testing
- Symptom Monitoring on Renal Replacement Therapy - Hemodialysis (SMaRRT-HD), Usual Care
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- University of Pennsylvania
Chronic Kidney Disease, Dialysis
Dose-finding Study of MCI-196
The Primary Objective of this study is to determine the initial starting doses of colestilan (MCI-196) in paediatric subjects with Chronic Kidney Disease Stage 5 on Dialysis and with Hyperphosphataemia.
- Conditions
- Chronic Kidney Disease, Dialysis, Hyperphosphatemia, Paediatric
- Trial name
- NCT01814904
- Testing
- colestilan-L, colestilan-M, colestilan-H
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Tanabe Pharma Corporation
Chronic Kidney Diseases, Dialysis
Dialysis Geriatric Care Model
The objectives of this study are to refine the dialysis care model with key stakeholder input and conduct a pilot randomized controlled trial (RCT) to obtain evidence critical to inform a definitive RCT.
- Conditions
- Chronic Kidney Diseases, Dialysis, Geriatric
- Trial name
- NCT05793138
- Testing
- Geriatric Care Model, Usual Care
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Duke University
End Stage Renal Disease, Pruritus
DIalysis Symptom COntrol-Pruritus Outcome Trial
The purpose of this study is to test whether or not a medication called nabilone, which is a synthetic (non-natural) medication derived from cannabis, compared to placebo improves symptoms of itch in hemodialysis as measured by…
- Trial name
- DISCO-POT (NCT05180968)
- Testing
- Nabilone 0.5 MG Oral Capsule
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
End Stage Renal Disease
The Measurement of Insulin Resistance in Peritoneal Dialysis Patients
The goal of this study is to examine the relevance of insulin resistance in peritoneal dialysis (PD) patients as well as the means to improve this metabolic derangement.
- Trial name
- NCT01119196
- Testing
- Icodextrin dialysate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University
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