Clinical trials: Diaphragm Injury
Diaphragm Injury
Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well.
- Trial name
- NCT03681275
- Testing
- Tofacitinib 10 MG [Xeljanz]
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Stanford University
Respiratory Insufficiency, Diaphragm Injury
Diaphragm Injury and Dysfunction During Mechanical Ventilation
This study is designed to evaluate the relationship between diaphragm activity during mechanical ventilation and the development of ventilator-induced diaphragm dysfunction (VIDD).
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Mechanical Ventilation Complication
- Trial name
- MYOTRAUMA (NCT03108118)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Diaphragm Injury, Weaning Failure
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
This study is designed to determine whether maximal diaphragm thickening fraction measured by ultrasound during volitional maximal inspiratory efforts is a valid measure of diaphragm function in mechanically ventilated patients.
- Conditions
- Diaphragm Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- SNIFF III (NCT03129217)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University Health Network, Toronto
Covid19, Diaphragm Injury
Respiratory Muscles After Hospitalisation for COVID-19
Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles especially following invasive mechanical ventilation in the Intensive Care Unit.
- Trial name
- REMAP-COVID-19 (NCT04854863)
- Testing
- Comprehensive assessment of respiratory muscle function.
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- RWTH Aachen University
COVID-19, Diaphragm Injury
Respiratory Muscles After Inspiratory Muscle Training After COVID-19
It is the aim of the current (follow-up) project for the first time in post-COVID-19 patients who continue to complain of shortness of breath and for whom there is no other explanation than possibly proven diaphragmatic weakness…
- Trial name
- NCT05582642
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- RWTH Aachen University
Covid19, Diaphragm Injury
Respiratory Muscle Assesment in COVID-patients Without Hospitalization
Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles. The aim of the project is to measure respiratory muscle function and strength in our respiratory…
- Trial name
- RMA-COVID-19 (NCT06105450)
- Testing
- Comprehensive assessment of respiratory muscle function.
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- RWTH Aachen University
Abdominal Injury, Pelvic Fracture
Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients
Unrecognized abdominal and pelvic injuries can result in catastrophic disability and death. Sporadic reports of "occult" injuries have generated concern, and physicians, fearing that they may miss such an injury, have adopted the…
- Conditions
- Abdominal Injury, Pelvic Fracture, Genital Hemorrhage, Lumbar Spine Injury
- Trial name
- NEXUS AP CT (NCT04937868)
- Testing
- There are no interventions associated with this study
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- University of California, Los Angeles
Ventilator Lung, Ventilator-Induced Lung Injury
Phrenic Identification in the ICU
This will be a prospective observational study where the investigator will scan patients' necks with an ultrasound and look for anatomical landmarks that may help identify the phrenic nerve.
- Conditions
- Ventilator Lung, Ventilator-Induced Lung Injury, Diaphragm Disease, Phrenic Nerve
- Trial name
- NCT05875883
- Testing
- Neck ultrasound
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Unity Health Toronto
Diaphragm Injury, Respiratory Failure
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
- Conditions
- Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- DIASPORA (NCT03667027)
- Testing
- Respiratory support
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Diaphragm Injury, Lung Transplant; Complications, Mechanical
Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation
The study is designed to characterize the changes in diaphragm function after lung transplantation.
- Conditions
- Diaphragm Injury, Lung Transplant; Complications, Mechanical, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- RADAR (NCT04103996)
- Testing
- Ultrasound, Respiratory function measurements
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Acute Hypoxemic Respiratory Failure, Diaphragm Injury
Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure
This is a single-center proof-of-concept clinical trial designed to establish the feasibility of transvenous phrenic-nerve stimulation (PNS) to maintain diaphragm activation over the first 24 hours and for up to seven days of…
- Conditions
- Acute Hypoxemic Respiratory Failure, Diaphragm Injury, Lung Injury
- Trial name
- STIMULUS (NCT05465083)
- Testing
- Lungpacer AeroPace Protect System
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Respiratory Insufficiency, Diaphragm Injury
Feasibility of Reducing Respiratory Drive Using the Through-flow System
Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury.
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Lung Injury
- Trial name
- Throughflow (NCT05642832)
- Testing
- Throughflow titration phase
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Diaphragm Injury, Lung Injury
Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work
This study is designed to test a proposed strategy for lung- and diaphragm-protective ventilation (LDPV) in patients with acute hypoxemic respiratory failure.
- Conditions
- Diaphragm Injury, Lung Injury, Respiratory Insufficiency, Mechanical Ventilation Complication
- Trial name
- LANDMARK (NCT03612583)
- Testing
- Lung- and Diaphragm-Protective Ventilation
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- University Health Network, Toronto
Diaphragm Injury, Mechanical Ventilation Complication
Evaluation of the Regeneration Capacity of Satellite Cells From the Quadriceps Compared to That of the Diaphragm
Actually no treatment exists to prevent the loss of diaphragmatic function induced by mechanical ventilation during an intensive care unit stay.
- Trial name
- ECARS (NCT05194631)
- Testing
- Quadriceps microbiopsy using a Tru-Cut biopsy needle
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Diaphragm Injury
Comparison of Supraclavicular and Costoclavicular Brachial Plexus Blocks in Adult Patients
Hemidiaphragmatic paresis is a common side effect of brachial plexus blocks such as supraclavicular or infraclavicular block techniques.
- Trial name
- NCT06329440
- Testing
- Ultrasonographic measurement of diaphragm thickness
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
ARDS, Human, Ventilator-Induced Lung Injury
Non-invasive Phrenic Nerve Stimulation in ARDS Patient
Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment.
- Conditions
- ARDS, Human, Ventilator-Induced Lung Injury, Diaphragm Injury
- Trial name
- NCT06572280
- Testing
- PNS group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Southeast University, China
Weaning Failure, Central Respiratory Depression
Exploration of Mechanisms for Weaning Failure
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline…
- Conditions
- Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
- Trial name
- NCT06424314
- Testing
- Monitoring of respiratory mechanics parameters
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Mechanical Ventilation Complication, Diaphragm Injury
Effect of Diaphragm Stimulation During Surgery
During major surgical procedures general anesthesia is used to make the patient unconscious. General anesthesia insures that the patient is unaware of any pain caused by surgery.
- Trial name
- NCT03303040
- Testing
- Electrical stimulation of hemidiaphragm
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Mechanical Ventilation Complication, Diaphragm Injury
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles.
- Conditions
- Mechanical Ventilation Complication, Diaphragm Injury, Lung Injury, Respiratory Insufficiency
- Trial name
- RESPIRE (NCT05857774)
- Testing
- Sonographic measurements, Physiological measurements, Biological measurements
- Where
- Canada
- Volunteers
- 230 people
- Sponsor
- University Health Network, Toronto
Respiratory Failure, Diaphragm Injury
Diaphragm Ultrasound as a Powerful Tool in Managing Acute Hypoxemic Respiratory Failure in Hematological Patients
Acute hypoxemic respiratory failure due to parenchymal disfunction is one of the main complications of immunocompromised hematological patients.
- Conditions
- Respiratory Failure, Diaphragm Injury, Ultrasound, Mechanical Ventilation Complication
- Trial name
- NCT04026217
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine