Clinical trials: Diaphragmatic Function
Systemic Sclerosis, Diaphragm Defect
Muscular Respiratory Involvement and Systemic Sclerosis
Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors.
- Conditions
- Systemic Sclerosis, Diaphragm Defect, Respiratory Insufficiency, Pulmonary Function Test
- Trial name
- SIROCO (NCT04118725)
- Testing
- Pulmonary function test
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Poitiers University Hospital
Respiration, Artificial
Improvement of Weaning From Mechanical Ventilation by Continuous Ultrasound Monitoring of Diaphragm Excursion
Justification: The diaphragm is the main inspiratory muscle. Its dysfunction therefore compromises ventilation, which is necessary for gas exchange. Diaphragmatic dysfunction is frequently observed in resuscitation patients.
- Trial name
- WEAN-US (NCT04008875)
- Where
- 3 sites in France
- Volunteers
- 39 people
- Sponsor
- Respinor AS
Respiratory Function Loss, Respiratory Complication
Shear-wave Elastography Compared to Respiratory Function Testing
The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts…
- Trial name
- NCT04959526
- Testing
- Shear-wave elastography
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Weaning Failure
The Effect of Doxapram Versus Theophylline on Diaphragmatic Function
Doxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage.
- Trial name
- NCT03894189
- Testing
- Doxapram Hydrochloride, Theophylline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Beni-Suef University
Mechanical Ventilation Complication, Diaphragm Injury
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles.
- Conditions
- Mechanical Ventilation Complication, Diaphragm Injury, Lung Injury, Respiratory Insufficiency
- Trial name
- RESPIRE (NCT05857774)
- Testing
- Sonographic measurements, Physiological measurements, Biological measurements
- Where
- Canada
- Volunteers
- 230 people
- Sponsor
- University Health Network, Toronto
Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome)
The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics
The goal of this interventional study is to evaluate the effect of different positive end-expiratory pressures (PEEP) on lung and diaphragm function in patients mechanically ventilated with pressure support ventilation in the…
- Conditions
- Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome), Pneumonia, Respiratory Insufficiency
- Trial name
- INFLATE-ICU (NCT07188038)
- Testing
- Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure
- Where
- 2 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Vastra Gotaland Region
Inspiratory Muscle Training, Postoperative Pulmonary Complications
The Cardiopulmonary Effects and Diaphragm Function of Complete Inspiratory Muscle Training in Patients With Upper Abdominal Surgery
Upper abdominal surgical treatment may have reduced respiratory muscle function and mucociliary clearance, which might be a consequence of postoperative pulmonary complications (PPCs).
- Conditions
- Inspiratory Muscle Training, Postoperative Pulmonary Complications, Respiratory Muscle Function, Abdominal Surgery
- Trial name
- NCT05239819
- Testing
- Inspiratory muscle training, Regulated care and education
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Cheng Kung University
Respiration, Artificial, Mechanical Ventilation
Continuous Evaluation of Diaphragm Function
Aim of mechanical ventilation is to improve gas exchange and to unload the respiratory muscles delivering a form of mechanical support to the ventilation.
- Conditions
- Respiration, Artificial, Mechanical Ventilation, Critical Illness
- Trial name
- NCT03941002
- Testing
- Assesment of diaphragm function
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Milan
Coronary Artery Disease, Post Coronary Artery Bypass Grafting
Aerobic and Resistance Training in Post-CABG Patients
This study investigates the effect of combined aerobic and resistance training using resistance bands on diaphragmatic excursion and pulmonary function (FVC, FEV₁, PEF) in post-CABG patients undergoing phase II cardiac…
- Trial name
- NCT07034937
- Testing
- Combination of aerobic training (treadmill walking) and resistance training
- Volunteers
- 15 people
- Sponsor
- Universitas Padjadjaran
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Healthy
Effects of Blood Gas Perturbations
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
- Trial name
- NCT07701603
- Testing
- Gas perturbation
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Thyroid Diseases, Respiratory Failure
Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome
Although it is now recognized that a variety of respiratory abnormalities, such as diaphragmatic dysfunction, can be present in primary hypothyroidism and reverse with adequate hormone treatment, the role of thyroid hormone…
- Trial name
- NCT03157466
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke
Reflexive Coughing Force in Severe Aspirators
To assess coughing force during reflex coughing test in those with severe dysphagia and severe aspiration and compare them to than those with stroke patients with no signs of dysphagia/aspiration.
- Trial name
- NCT02080988
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Swimming, Inspiratory Muscle Strength
Effects of Inspiratory Training on Respiratory Function in Swimming
Introduction: The diaphragm is the primary inspiratory muscle and plays a key role in ventilation, trunk stability, and exercise efficiency.
- Conditions
- Swimming, Inspiratory Muscle Strength, Inspiratory Muscle Training
- Trial name
- NCT07595341
- Testing
- Inspiratory training
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Stress Urinary Incontinence (SUI)
Effects of Diaphragmatic Breathing With Kegal Exercises on Pelvic Floor Muscle Function and Quality of Life Among Multigravida Women With Stress Incontinence
The goal of this clinical trial is to determine the effect of diaphragmatic breathing with kegel exercises on pelvic floor muscle function and quality of life among multigravida women with stress urinary incontinence The main…
- Trial name
- NCT07537309
- Testing
- Diaphragmatic Breathing, Kegel exercises
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Mechanical Ventilation, Expiratory Muscle
Expiratory Muscle Function in Critically Ill Ventilated Patients
Inspiratory muscle weakness develops rapidly in ventilated critically ill patients and is associated with adverse outcome, including prolonged duration of mechanical ventilation and mortality.
- Conditions
- Mechanical Ventilation, Expiratory Muscle, Critical Illness, Muscle Atrophy or Weakness
- Trial name
- EMFIC (NCT04333186)
- Testing
- Data from ultrasound measurements
- Where
- Netherlands
- Volunteers
- 113 people
- Sponsor
- Amsterdam UMC, location VUmc
Preterm, Premature
Effects of Kinesiotaping on Respiratory Muscles in Very Preterm Infants
This study aimed to evaluate the effects of kinesio taping on blood gas parameters, respiratory rate, heart rate, oxygen saturation, and pressure limits in preterm infants with RDS who are on NIV.
- Conditions
- Preterm, Premature, Infant, Newborn, Diseases, Respiratory Distress Syndrome
- Trial name
- NCT06285669
- Testing
- kinesiotaping application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ondokuz Mayıs University
Esophageal Cancer, Postoperative Complications
Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches
Worldwide, esophageal cancer is the 6th most common cause of cancer-related death. Currently curative resection remains the cornerstone of the therapy.
- Conditions
- Esophageal Cancer, Postoperative Complications, Diaphragm, Pulmonary Function
- Trial name
- NCT01053182
- Testing
- Ivor-Lewis Esophagectomy, Sweet Esophagectomy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Sichuan University
Back Pain, Lumbar Pain Syndrome
Effects of Spinal Manipulation in Patients With Nonspecific Low Back Pain
Introduction: Nonspecific low back pain is the most common cause of visits to medical personnel and is the largest cause of absenteeism in the world.
- Conditions
- Back Pain, Lumbar Pain Syndrome, Back Pain, Low
- Trial name
- NCT05080374
- Testing
- Spinal Manipulation + exercise program, Spinal manipulation + Kinesiotaping, spinal manipulation + respiratory exercise
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Ignacio Alejandro Astudillo Ganora
Postoperative Pain, Shoulder Arthroscopic Surgeries
Interscalene Block Versus Infraspinatus-Teres Minor Interfascial Plane Block for Shoulder Arthroscopy
This prospective randomized controlled study aims to compare the effects of interscalene block, infraspinatus-teres minor interfascial plane block, and a control group on postoperative analgesia and diaphragmatic function in…
- Conditions
- Postoperative Pain, Shoulder Arthroscopic Surgeries, Diaphragmatic Dysfunction
- Trial name
- NCT07670780
- Testing
- Ultrasound-Guided Interscalene Block, Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Plane Block
- Volunteers
- 120 people
- Sponsor
- TC Erciyes University