Clinical trials: Diarrheal Disease
Cholera, Diarrhea
Cholera-Hospital-Based-Intervention-for-7-days
The Cholera Hospital Based Intervention for 7 Days (CHoBI7) randomized controlled trial for transition to scale aimed to: (1) Develop and evaluate scalable approaches to integrate the CHoBI7 intervention into the services…
- Conditions
- Cholera, Diarrhea, Stunting
- Trial name
- CHoBI7 (NCT04008134)
- Testing
- CHoBI7 health facility program, CHoBI7 mHealth program, CHoBI7 home visit program
- Volunteers
- 2,626 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diarrhea Infectious
Study in Healthy Adults Challenged With Enterotoxigenic E. Coli, of the Safety, Tolerability and Anti-Diarrheal Activity of VENBETA6890, an Orally Administered, Human Monoclonal IgA
This is a phase 1, randomized, placebo-controlled, blinded study in up to 36 healthy adults, aged 18-45 years, challenged with Enterotoxigenic Escherichia coli, evaluating the safety, tolerability and anti-diarrheal activity of…
- Trial name
- MBL-ETEC-21-01 (NCT06896136)
- Testing
- VENBETA6890
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mark Klempner
Diarrhea, Malnutrition
Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development
Malnutrition is considered one of the most prevalent risk factors for morbidity and mortality in children under five. An estimated 20% of children in the developing world are malnourished [1] and poor nutrition is linked to more…
- Conditions
- Diarrhea, Malnutrition, Stunting, Wasting
- Trial name
- MAL-ED (NCT02441426)
- Where
- 8 sites in Bangladesh, Brazil and 6 more
- Volunteers
- 1,796 people, healthy volunteers welcome
- Sponsor
- Foundation for the National Institutes of Health
Healthy Volunteers
Effects of Lactobacillus Casei on Respiratory and Gastrointestinal Diseases in Adults
This project aims to study the benefits of probiotics namely Lactobacillus casei Zhang (LCZ) in prevention of upper respiratory and gastrointestinal illnesses, which are found common among adults in Malaysia aged from 18 to 81…
- Trial name
- NCT02541539
- Testing
- Lactobacillus casei Zhang
- Where
- Malaysia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Intestinal Helminthiasis, Diarrhea
The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
Cheap and effective drugs called 'anthelmintics' are routinely administered to children in developing countries to eliminate infections by parasitic helminths.
- Trial name
- NCT02597556
- Testing
- Albendazole
- Where
- Vietnam
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Diarrhoeal Disease, Hookworm Infection
Evaluating Impact of Improved Floors on Health
The goal of this intervention study is to learn about the impact of household flooring on health in rural Kenya, and test whether providing an improved (cement stabilised, washable) floor improves the health of children and their…
- Conditions
- Diarrhoeal Disease, Hookworm Infection, Ascaris Lumbricoides Infection, Trichuris Infection
- Trial name
- SABABU (NCT05914363)
- Testing
- Sealed washable floor plus behaviour change, Behaviour change intervention, Routine deworming
- Where
- Kenya
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malnutrition, Diarrhea
Evaluation of Zinc and / or Micronutrient Supplementation on Intestinal Flora, Diarrheal Disease Burden, Intestinal Mucosal Integrity and Growth Among Children of Pakistan
Information on the mechanisms of zinc is still in developing phase. Ecological and biological implications of long term zinc supplementation at population level requires assessment.
- Conditions
- Malnutrition, Diarrhea, Pneumonia, Growth
- Trial name
- NCT00705445
- Testing
- Micronutrient Supplementation without Zinc, Micronutrient Supplementation with Zinc, Nutritional Counselling and Education
- Where
- 2 sites in Pakistan
- Volunteers
- 2,745 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Non-erosive Reflux Disease/Diarrheal Irritable Bowel Syndrome
Study on the Rule and Mechanism of Treating Functional Gastrointestinal Diseases From the Perspective of Liver and Spleen
To clarify the changes of intestinal flora - gut - brain axis in FGIDs patients represented by NERD disharmony of liver and stomach and IBS-D disharmony of liver and spleen, and confirm that the imbalance between intestinal flora…
- Trial name
- NCT04454996
- Testing
- tong-jiang granules, Chang 'an II Recipe
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Diarrheal Diseases, Acute Respiratory Infections
Evaluation of Novel Antimicrobial Hand Towels
In March 2012, the investigators initiated a prospective, cluster-randomized, controlled field trial in Kisumu County, located in an area in western Kenya which has the highest under-five mortality rate in Kenya with 149…
- Conditions
- Diarrheal Diseases, Acute Respiratory Infections, Fever, Skin Infection
- Trial name
- NCT02512614
- Testing
- Antimicrobial Hand Towel
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Diarrheal Diseases
Reducing Filth Fly Populations and Transmission of Diarrhoeal Pathogens in Harsh Settings
Objectives The main trial objective is to evaluate the efficacy of larvicide (LARV) or baited fly traps (TRAP), or both interventions combined, on filth fly density and hence transmission of diarrhoeal diseases.
- Trial name
- NCT07272122
- Testing
- Baited fly traps - iCatchi® ProMax fly traps, Insect growth regulator (IGR) - effervescent granule containing 2% diflubenzuron (20g/kg)
- Where
- South Sudan
- Volunteers
- 5,556 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Seroimmunity, Diarrhea
Diarrhea and Bivalent Oral Polio Vaccine Immunity
Global eradication of poliomyelitis has proven to be elusive. Although 99% of cases have been eliminated since 1988, outbreaks continue to occur, and new tools are needed to accelerate eradication.
- Conditions
- Seroimmunity, Diarrhea, Polio
- Trial name
- NCT01559636
- Testing
- bivalent oral polio vaccine
- Where
- Nepal
- Volunteers
- 699 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Diarrhoeal Disease
Development of a Live Attenuated Rotavirus Vaccine as a Human Infection Challenge Model
The impact of licensed rotavirus vaccines in LMICs is limited by their lower immunogenicity and efficacy in these settings. Improved vaccines and vaccination schedules would result in substantially greater reductions in infant…
- Trial name
- NCT04123119
- Testing
- Rotavirus vaccine
- Where
- Zambia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Diarrhoeal Disease
Health Impact of Treating and Safely Storing Shallow Tubewell Drinking Water
When shallow tubewells replaced highly contaminated surface water as the primary source of drinking water in Bangladesh in the late 20th century, contemporary studies demonstrated no reduction in diarrheal disease with this…
- Trial name
- NCT01350063
- Testing
- Sodium dichloroisocyanurate (NaDCC) tablet (Aquatab), Water storage container (Jerry can), No intervention
- Where
- Bangladesh
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Compliant Behavior, Diarrheal Disease
Rural China Electric Kettle Promotion Program
This study will evaluate the impact of a pilot Rural Electric Kettle Promotion Program offered to low-income households in rural Anhui Province, China.
- Conditions
- Compliant Behavior, Diarrheal Disease, Pollution; Exposure
- Trial name
- NCT03376152
- Testing
- Electric Kettle Promotion
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Diarrhea
Prevention of Diarrheal Disease Due to Infection With Enterotoxigenic E. Coli (ETEC)
This is a Phase II b, double-blind, randomized, placebo-controlled study in healthy adults (age 18-65 years) to evaluate the safety, immunogenicity, different diagnostic tools and efficacy of ETVAX.
- Trial name
- NCT03729219
- Testing
- E. coli ETVAX
- Where
- Finland
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Scandinavian Biopharma AB
Enteric Infections, Diarrhea
The Safe Start Trial - Kisumu, Kenya
This a cluster randomised controlled trial (cRCT) to evaluate the effect of a novel food hygiene intervention on infant health.
- Trial name
- NCT03468114
- Testing
- Safe Start, Active Control
- Where
- Kenya
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cryptosporidium; Diarrhea, Cryptosporidiosis
Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya
The aim of the study is to examine the efficacy of ceramic water filters to reduce the burden of waterborne diarrheal illness among infants in selected villages in Kenya.
- Conditions
- Cryptosporidium; Diarrhea, Cryptosporidiosis, Communicable Diseases, Diarrheal Disease
- Trial name
- NCT01695304
- Testing
- Ceramic water filter
- Where
- Kenya
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Healthy, Diarrhea
Calcium, Probiotics and Acute Diarrheal Disease Among Indonesian Children
This is a long term study on the efficacy of dietary calcium with or without probiotic strains in reducing the mean number of episodes and duration of diarrheal disease.
- Trial name
- NCT00512824
- Testing
- low calcium milk of 180 ml, regular milk of 180 ml, regular milk of 180 ml + probiotics
- Where
- Indonesia
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Acute Respiratory Infection, Diarrheal Disease
Efficacy and Tolerance of a Follow-On Formula Fed to Children From 36-48 Months of Age
The purpose is to determine if the consumption of study product has an effect on acute respiratory infections and/or diarrheal disease.
- Trial name
- NCT01488435
- Testing
- Cow's milk, Follow-On Formula
- Where
- China
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Dietary Rice Bran Supplementation
Pilot Feasibility of Rice Bran Supplementation in Children
The purpose of this study is to assess feasibility of rice bran consumption in weaning children and to identify dietary rice bran mediated changes to the stool microbiome and stool metabolome.
- Trial name
- NCT02557373
- Testing
- Vitamin A, Rice Bran + Vitamin A
- Where
- 2 sites in United States, Mali
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Colorado State University