Clinical trials: Dietary Carbohydrates
Type1diabetes, Low Carbohydrate Diet
Metabolic Changes Induced by a Very Low Carbohydrate Diet in Youth With Type 1 Diabetes
As more adolescents with type 1 diabetes (T1D) opt to follow very low carbohydrate diets to improve glucose control, it is becoming increasingly important to study the metabolic and neurological changes that occur on these diets…
- Trial name
- NCT04955691
- Testing
- low carbohydrate diet, standard carbohydrate diet
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Yale University
Diabetes Mellitus, Diabetes Mellitus, Type 2
Effect of High Carbohydrate vs. Low Carbohydrate Diet in Type 2 Diabetes
The experimental approach in this study intends to investigate the role of hepatic glycogen content on nocturnal regulation of endogenous glucose production including the relative contributions of glycogenolysis and…
- Trial name
- NCT04416204
- Testing
- glycogen loading, No Glycogen Loading
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy, Healthy Volunteers
Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism
Background: Researchers want to learn how different diets affect hormone levels, body weight, energy expenditure, liver fat, and more. To do this, they will use specialized techniques and food plans.
- Trial name
- NCT03878108
- Testing
- LCHF diet, LFHC diet
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes Mellitus in Obese
REmote SUpport for Low-Carbohydrate Treatment of Type 2 Diabetes
Excess adiposity is a key causal factor in developing type 2 diabetes and weight loss improves glycaemia and can put diabetes in to remission. There is evidence that low carbohydrate diets also reduce glycaemia.
- Trial name
- RESULT (NCT04916314)
- Testing
- Low Carbohydrate diet
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- University of Oxford
Pre-diabetes
Continuous Glucose Monitoring (CGM) With a Low Carbohydrate Diet to Reduce Weight in Patients With Pre-Diabetes
This study will recruit pre-diabetic patients to see if continuous glucose monitoring (CGM) with a low carbohydrate diet can reduce the percentage of time the CGM readings are above the normal range.
- Trial name
- NCT03695913
- Testing
- Normal Diet, Low carb diet, CGM with no real time feedback
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Type 2 Diabetes, High Blood Sugar
Evaluate Efficacy and Safety in Japanese Subjects With Type 2 Diabetes Mellitus
This is a 24-week randomised, multi-centre phase III study to evaluate the efficacy and safety of dapagliflozin as monotherapy in Japanese subjects with Type 2 diabetes mellitus who have inadequate glycemic control with diet and…
- Trial name
- NCT01294423
- Testing
- Dapagliflozin
- Where
- 26 sites in Japan
- Volunteers
- 261 people
- Sponsor
- AstraZeneca
Dietary Recommendations
Dietary Recommendations for Reducing Free Sugar Intakes
This randomised controlled trial aims to assess the impacts of the current recommendations by Public Health England for reducing free sugar intakes, on total energy intakes of free sugar in a sample of the UK population.
- Trial name
- NCT04816955
- Testing
- Dietary recommendations
- Where
- United Kingdom
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Gynecology
An Endometrial Cancer Chemoprevention Study of Metformin
The goal of this clinical research study is to learn about the effects of metformin and/or a program called "lifestyle intervention" on the endometrium (inner lining of the uterus) in post-menopausal women who are also obese…
- Trial name
- NCT01697566
- Testing
- Metformin, Endometrial Biopsy, Lifestyle Intervention
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cancer
Ketogenic Diet in Advanced Cancer
The purpose of this study is to determine the safety and tolerability of a modified low carbohydrate diet, determine if quality of life is improved and to determine if the diet has any effect on tumor growth (size or spread) and…
- Trial name
- NCT01716468
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Pittsburgh Healthcare System
Dietary Habits
Impact of Warnings on Sugar-Sweetened Beverages
The purpose of this randomized controlled trial is to determine whether pictorial warnings on sugar-sweetened beverages are more effective than neutral labels at reducing parents' purchases of sugar-sweetened beverages for their…
- Trial name
- NCT04223687
- Testing
- Sugar-Sweetened Beverage Warning Label, Neutral label
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hyperinsulinemia, Insulin Resistance
EMPOWIR:Enhance the Metabolic Profile of Women With Insulin Resistance
The goal of the study is to identify and treat women with midlife weight gain who have normal blood sugars, but increased insulin levels (hyperinsulinemia) following the performance of a glucose tolerance test.
- Conditions
- Hyperinsulinemia, Insulin Resistance, Obesity
- Trial name
- EMPOWIR (NCT00618072)
- Testing
- metformin and rosiglitazone
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Aging, Healthy Diet
The Effects of Added Sugar Intake on Brain Blood Flow and Hippocampal Function in Midlife Adults
This study will focus on improving brain health through dietary modification of added sugars in middle aged adults (50- 64 years old).
- Trial name
- NCT05211726
- Testing
- Low Added Sugar Diet, High Added Sugar Diet
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Low-grade Chronic Inflammation, Intestinal Permeability
Diet and Systemic Inflammation
People with chronic low-grade inflammation have a higher risk for certain diseases such as cardiovascular disease or type 2 diabetes.
- Conditions
- Low-grade Chronic Inflammation, Intestinal Permeability, Type 2 Diabetes Mellitus, Cardiovascular Disease
- Trial name
- DASI (NCT01424306)
- Testing
- Fructose-sweetened beverages, Glucose-sweetened beverages, High-fructose corn syrup-sweetened beverages
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Recurrent Miscarriage
Walking and Dietary Modification for Recurrent Early Miscarriages
This study is part of a big one aiming to evaluate how lifestyle interventions during pregnancy affect obstetric results, neonatal metabolism and the intelligence of the offspring (study not yet completed).
- Trial name
- W&D (NCT03023137)
- Testing
- Walking & dietary modification
- Where
- Brazil
- Volunteers
- 480 people
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Diabetes Mellitus, Diet
LoBAG30 Diet in Patients on Metformin
We will determine the metabolic response to a Low Biologically Available Glucose Diet (LoBAG30) in subjects currently receiving the maximum dose of metformin as monotherapy in whom the glycohemoglobin is not at an acceptable…
- Trial name
- LoBAG Diet (NCT00607867)
- Testing
- LoBAG30 diet, Control Diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- US Department of Veterans Affairs
Physical Activity, Diet Modification
Dietary Carbohydrate Manipulation and Energy Balance: RCT
This study will investigate how dietary sugar and carbohydrates influence metabolism and health across a 12-week period, with a focus on physical activity.
- Trial name
- NCT03574987
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bath
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia).
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT04614168
- Testing
- Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Crohn Disease
Trial of Specific Carbohydrate and Mediterranean Diets to Induce Remission of Crohn's Disease
This protocol is designed to compare the effectiveness of two dietary interventions for patients with Crohn's disease (CD): the Specific Carbohydrate Diet (SCD) and a Mediterranean style diet (MSD) that has been demonstrated to…
- Trial name
- DINE-CD (NCT03058679)
- Testing
- Diet
- Where
- 35 sites in United States
- Volunteers
- 197 people
- Sponsor
- University of Pennsylvania
Diarrhea Predominant Irritable Bowel Syndrome
Effects of a Very Low Carbohydrate Diet on Symptoms of Irritable Bowel Syndrome (IBS)
The purposes of this study are to prospectively determine the effect of a very low carbohydrate diet on quality of life and gastrointestinal symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS-D); and to…
- Trial name
- NCT00616200
- Testing
- Very low carbohydrate diet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes
Study To Evaluate 24 Hour Blood Sugar Control (24-hour Mean Weighted Glucose) In Subjects That Are Taking Saxagliptin 5 mg Added Onto Metformin XR 1500 XR mg Compared To Subjects Taking Metformin XR 1500 mg Up-titrated To Metformin XR 2000 mg
The purpose of this study was to compare effect of Saxagliptin as add-on to Metformin on 24-hour mean weighted glucose (MWG) to the effect of uptitrating Metformin in subjects with T2DM inadequately controlled on metformin alone.
- Trial name
- NCT00918138
- Testing
- Saxagliptin, Metformin XR
- Where
- 21 sites in United States, Argentina and 2 more
- Volunteers
- 219 people
- Sponsor
- AstraZeneca