Clinical trials: Dietary Fats
Healthy
Diets With a Spectrum of Fat Intake for Preventing Obesity: A Randomized Controlled-feeding Trial
The aim of the current study is to evaluate the effects of diets with three levels of dietary fat on weight change and related cardiometabolic risk factors in a 6-month randomized controlled-feeding trial.
- Trial name
- NCT02355795
- Testing
- low-fat diet, moderate-fat diet, high-fat diet
- Where
- China
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Overweight, Cardiovascular Diseases
Dietary Fat and High-Density Lipoprotein (HDL) Metabolism-Effect of Carbohydrate and Fat Intake
Generally, people with low levels of high-density lipoprotein (HDL) in blood are more likely to get heart disease than those who have normal or high levels.
- Trial name
- NCT01399632
- Testing
- Low Fat and High Carbohydrate Diet, High Fat and Low Carbohydrate Diet
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Risk Factor
Trial of Different Dietary Fats on Blood Lipids and Metabolic Measures in Healthy Participants
This is a randomised trial in which healthy volunteers, men and women aged 50-75 years from the general community are randomized into one of three arms: participants will be provided with 50 gm extra virgin coconut oil,or 50…
- Trial name
- COB (NCT03105947)
- Testing
- Coconut oil, Butter, Olive oil
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Ectopic Lipids, Insulin Sensitivity
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.
This study aims at assessing the effect of standardized dietary fat load and short-term aerobic exercise on systemic lipolysis, flexibility and partitioning of ectopic fat stores (intramyocellular = IMCL, intrahepatocellular =…
- Conditions
- Ectopic Lipids, Insulin Sensitivity, Aerobic Exercise, Fat Load
- Trial name
- NCT01467193
- Testing
- Fat diet, 2h standardized aerobic exercise
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Metabolic Syndrome
The Effect of Dietary Fat Modification on Risk Factors Associated With the Metabolic Syndrome
The LIPGENE Human Dietary Intervention Study, multi-centre, trans -European, single-blinded, randomised, controlled trial with two principal aims.
- Trial name
- NCT00429195
- Testing
- Dietary Fatty Acid Modification
- Where
- Ireland
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Insulin Resistance
Dietary Lipid Induced Insulin Resistance
The overall goal of the proposal is to use a saturated fatty acid (SFA)- enriched, high fat diet to rapidly induce insulin resistance (IR) to provide insight into underlying proximal mechanisms of reduced insulin signaling.
- Trial name
- NCT02757560
- Testing
- SFA diet, MUFA diet, CARB diet
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Phoenix VA Health Care System
Healthy
Oscillations of Dietary Fat/Carbohydrate Intake Over Interval of 3 to 4 Days
The purpose of this study is to understand the mechanisms for oscillations of dietary fat/carbohydrate intake and how fat intake affect insulin resistance and liver fat over interval of 3 to 4 days.
- Trial name
- Dietitian II (NCT01115075)
- Testing
- Dietary fat/intake of carbohydrate, Spontaneous oscillations of dietary fat/intake of carbohydrate in relation to energy intake.
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Healthy
Effect of Dietary Fat Type in Combination With High Protein on Plasma Homocysteine Levels
In this study, the investigators address the research question of whether palm olein will have a positive influence on plasma total homocysteine levels in human volunteers provided with high-protein diets formulated from common…
- Trial name
- NCT00941837
- Testing
- Olive Oil, Palm Olein Oil, Coconut Oil
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Obesity
Acceptability of Dietary Fibre-based Foods
Obesity is a wide reaching problem in the United Kingdom. The most widely used obesity therapies are based around drugs that reduce dietary fat digestion, and thereby reduce uptake of calories from the diet.
- Trial name
- NCT03477981
- Testing
- Alginate bread
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Obesity
Hummus for Health: Dietary Quality and Health Outcomes in Toddlers
The goal of this study is to examine the effect of increasing children's intake of fiber and unsaturated fat, through daily servings of hummus and vegetables, on their microbiome profile.
- Trial name
- NCT02696278
- Testing
- Lesson about vegetables, Vegetables, Hummus
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Dietary Modification
Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake
The capacity to burn fat as fuel for exercise may have important implications for sporting performance, with dietary fat intake positively influencing this ability.
- Trial name
- NCT02568592
- Testing
- High Fat, Normal, Normal + Extra Fat
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Endotoxemia
The Role of Dietary Fat on Postprandial Endotoxemia in Healthy Adults
The purpose of this study was to determine the effect of different dietary fats (saturated or unsaturated) on postprandial endotoxemia and systemic low grade acute inflammation.
- Trial name
- NCT02521779
- Testing
- Low-fat Treatment Meal, Saturated-fat Treatment Meal, N-3 fat Treatment Meal
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Atherosclerosis
A Human In Vivo Feeding Study Of The Blood Monocyte Response To Dietary Lipid Intake
The aim of the present study is to identify the effects of different dietary fats on the body's immune system and how different types of cells respond.
- Trial name
- Lipophage14 (NCT02101346)
- Testing
- Mixed High Fat Diet, Saturated fat diet, Monounsaturated fat diet
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dietary Fats, Pharmacokinetics
The Effect of Food (High Fat and Low Fat Breakfast) on the Pharmacokinetics of Regorafenib
An open label, three way crossover study to determine the effect of a high fat breakfast or a low fat breakfast on the pharmacokinetics of a single dose of regorafenib.
- Trial name
- NCT01002378
- Testing
- Regorafenib (Stivarga, BAY73-4506)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy Conditions
Diet Induced Intestinal Mucosal Adaptation
Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract.
- Trial name
- NCT02088853
- Testing
- high fat diet (hfd), then high carbohydrate diet, high carbohydrate diet, then high fat diet
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Postprandial Period, Lipemia
Vascular Effects of Triglyceride-rich Lipoproteins
Many types of cardiovascular disease begin when the layer of cells lining blood vessels (endothelial cells) start to function abnormally.
- Conditions
- Postprandial Period, Lipemia, Vasodilation, Vascular Resistance
- Trial name
- NCT01618071
- Testing
- High-fat meals varying in their fatty acid composition
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- King's College London
Lipids
Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects
In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week…
- Trial name
- NCT02549144
- Testing
- Low fat/cholesterol diet, High fat/cholesterol diet
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Healthy
Palmitate Study: A Method Study of Dietary Lipid Oxidation in Toddlers
The purpose of this research is to measure how toddlers burn fat after drinking milk that has some fat molecules that can be tracked based on how heavy they are.
- Trial name
- NCT04408833
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Overweight and Obesity, Type 2 Diabetes
Fat Metabolites and Gut Hormones
To investigate the effects of different fat metabolites on gut hormone secretion in gastric bypass operated subjects and BMI-matched controls.
- Conditions
- Overweight and Obesity, Type 2 Diabetes, Bariatric Surgery, Gut Hormones
- Trial name
- NCT03223389
- Testing
- C-8 dietary oil, Tricaprylin, Olive oil
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Metabolic Disease
Body Fat Distribution and Fat Metabolism
The primary purpose of the study is to examine the effect of body fat distribution on the physiological response to a dietary fat intervention.
- Trial name
- NCT00475774
- Testing
- Long-chain (C18:2) and medium chain fatty acid (C8 and C10).
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- TNO