Clinical trials: Dietary Manipulation
Crohns Disease
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Crohn Disease on Advanced Therapies
Advanced therapies including biologics and small molecules target specific inflammatory pathways. IBD's multifactorial etiology means that blocking a single pathway may not be sufficient for all patients.
- Trial name
- BOOST-CD (NCT06890637)
- Testing
- Fecal Microbial Transplantation, Crohns Disease Exclusion Diet, Advanced therapy
- Where
- 6 sites in India
- Volunteers
- 168 people
- Sponsor
- All India Institute of Medical Sciences
Colorectal Cancer
Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery
A single arm, prospective, single center Phase1/2 Dietary intervention trial for subjects diagnosed with colorectal cancer and scheduled for tumor resection more than 21 days from informed consent.
- Trial name
- DIET (NCT06349590)
- Testing
- High-fiber/low-fat meals
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Dietary Modification
Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake
The capacity to burn fat as fuel for exercise may have important implications for sporting performance, with dietary fat intake positively influencing this ability.
- Trial name
- NCT02568592
- Testing
- High Fat, Normal, Normal + Extra Fat
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Physical Activity, Diet Modification
Dietary Carbohydrate Manipulation and Energy Balance: RCT
This study will investigate how dietary sugar and carbohydrates influence metabolism and health across a 12-week period, with a focus on physical activity.
- Trial name
- NCT03574987
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bath
Obesity, Insulin Resistance
Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
The purpose of this research study is to 1) understand how some, but not all people with obesity develop obesity related conditions such as type 2 diabetes and cardiovascular disease, and 2) compare the effects of 3 popular…
- Trial name
- NCT02706262
- Testing
- Metabolically abnormal obese - Mediterranean diet, Metabolically abnormal obese - Low carbohydrate ketogenic diet, Metabolically abnormal obese - Plant-based, very-low-fat diet
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Diabetes Mellitus Type 2
Diet, Insulin Sensitivity And the Brain
Obesity and insulin resistance may be in part explained by an altered reward system with changes in the serotonin/dopamine system.
- Trial name
- DISAB (NCT01297738)
- Testing
- Meal size increase with HFHS, Meal size increase with HS, Meal frequency increase with HFHS
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetes Mellitus
Metabolic Effects of the Manipulation of Nutrient Sequence in the Main Meals in Type 2 Diabetic Patients
The investigators aimed at evaluating the metabolic effects of the inversion of the typical Italian sequence of food ingestion at the main meals in type 2 diabetic patients.
- Trial name
- NCT02442024
- Testing
- Modified Diet, Standard Diet
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Fasting, Non-alcoholic Fatty Liver Disease (NAFLD)
Regulation of FGF21 by Nutritional Challenges
The purpose of this study is to examine how acute nutritional challenges affect levels of several proteins involved in metabolism. These proteins will be measured in blood and fat tissue. This study will have several aims.
- Trial name
- NCT00968747
- Testing
- Fasting, Diet, oral carbohydrate challenge
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Crohn Disease
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Newly Diagnosed Active Crohn Disease
Dysbiosis can be rectified by several methods: antibiotics, prebiotics, probiotics, dietary modulation, and fecal microbiota transplantation.
- Trial name
- ALTER-CD (NCT06890650)
- Testing
- Fecal Microbial Transplantation, Crohns disease exclusion diet
- Where
- 6 sites in India
- Volunteers
- 168 people
- Sponsor
- All India Institute of Medical Sciences
Focus: Anabolic Response to Food Intake in Young Individuals, Condition Relevance: Skeletal Muscle Health, Sarcopenia
Manipulation of Dietary Protein and the Anabolic Response
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.
- Trial name
- PRO-ADAPT (NCT01820975)
- Testing
- High protein intake
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Nutrition and Energy Balance
Acute Responses to Dietary Carbohydrate Manipulation
Sugar is perceived negatively, leading to government taxation and targets to reduce consumption. These actions have been taken based on the limited evidence that high-sugar diets are associated with greater total energy intake.
- Trial name
- NCT03509610
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Bath
Ulcerative Colitis
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Ulcerative Colitis on Advanced Therapies
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon characterized by superficial mucosal inflammation. Treatment aims to achieve and maintain remission, improve quality of life, and minimize complications.
- Trial name
- BOOST-UC (NCT06906445)
- Testing
- Fecal Microbial Transplantation, Anti-Inflammatory Diet, Advanced Therapy
- Where
- 6 sites in India
- Volunteers
- 220 people
- Sponsor
- All India Institute of Medical Sciences
Diet, Carbohydrate-Restricted
Effects of Diet Manipulation on Women in the Curves Program
The purpose of this study is to look at the effects of a carbohydrate restricted, high protein, high fat diet on weight loss and health outcomes in women participating in the Curves Fitness and Weight Loss Program.
- Trial name
- Curves2 (NCT03093792)
- Testing
- Control, American Heart Association plus exercise, Curves Complete - I plus exercise
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Ulcerative Colitis (UC)
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Newly Diagnosed Active Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon and rectum, characterized by mucosal inflammation and symptomslike diarrhea, abdominal pain, and rectal bleeding.
- Trial name
- ALTER-UC (NCT06895252)
- Testing
- Anti inflammatory diet, Fecal Microbial Transplantation
- Where
- 6 sites in India
- Volunteers
- 220 people
- Sponsor
- All India Institute of Medical Sciences
Type 1 Diabetes Mellitus
Nutritional Prevention Pilot Trial for Type 1 Diabetes
The overall objective of the study is to assess whether complete avoidance of cow's milk (CM) proteins, for at least the first 6 months of life, prevents type 1 diabetes (insulin-dependent diabetes mellitus, IDDM) in genetically…
- Trial name
- MIP (NCT00570102)
- Testing
- A highly hydrolyzed formula, A regular cow's milk based formula
- Where
- 18 sites in Finland
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Hematopoietic Stem Cell Transplantation
Dietary Manipulation of the Microbiome-metabolomic Axis for Mitigating GVHD in Allo HCT Patients
Investigators are evaluating the feasibility, safety and early efficacy of administering a commercially available dietary supplement containing potato-based resistant starch to subjects undergoing allogeneic SCT (stem cell…
- Trial name
- NCT02763033
- Testing
- Bob's Red Mill®
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Michigan Rogel Cancer Center
Metabolic Regulation, Fasting
Effects of Dietary Manipulation on Metabolism in Healthy Adults
This study will examine the potential changes in the blood levels of a recently discovered metabolic regulator in response to changes in diet in healthy adults.
- Conditions
- Metabolic Regulation, Fasting, Ketogenic Diet
- Trial name
- NCT00476125
- Testing
- Dietary manipulation ketogenic diet, Dietary Manipulation - 12 day ketogenic diet, 16 Hour Fast
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Dietary Manipulation
Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise
This study will investigate the effect of dietary macronutrient manipulation on glycogen (stored carbohydrate) levels in the muscle and substrate oxidation during exercise.
- Trial name
- NCT02605291
- Testing
- Diet with a different macronutrient content A, Diet with a different macronutrient content B, Diet with a different macronutrient content C
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Cardiovascular Diseases
Study Into Genetic Influence on Cholesterol Response to Dietary Fat
Cardiovascular disease (CVD) is recognised as one of the main causes of death in the western world. LDL- cholesterol ('bad' cholesterol) and other lipids (fats) are important CVD risk factors.
- Trial name
- Satgene (NCT01384032)
- Testing
- Low fat diet, Hgih saturated fat diet, High saturated fat diet
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Reading
Breastfeeding
is Dietary Manipulation of Human Milk Total Fat and Caloric Content Feasible?
The aim of this study is to verify whether dietary manipulations in lactating women allow increasing the fat and caloric content of human milk.
- Trial name
- NCT00408980
- Testing
- Fat and calorie controlled diet
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center