Clinical trials: Dietary Supplement: Ketone Supplement
Exercise, Ketones
The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source.
- Conditions
- Exercise, Ketones, Dietary Supplements
- Trial name
- NCT02825823
- Testing
- Ketone Salt
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Alcohol Drinking
Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers
This is a single blinded, randomized trial to evaluate the immediate subjective and objective effects of alcohol after a dose ketone supplement compared to a placebo in 10 health volunteers.
- Trial name
- NCT05551754
- Testing
- Ketone Supplement, Alcohol Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Migraine Headache
Ketone for Migraine Prevention
Efficacy of a nutritional ketogenic supplement (NKS) in reducing the number, intensity, and duration of migraine headaches in episodic migraine patients.
- Trial name
- NCT05085483
- Testing
- Nutritional Ketogenic Supplement
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Société des Produits Nestlé (SPN)
Diabetes, Hyperglycemia
Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes
Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate "keto" diet.
- Conditions
- Diabetes, Hyperglycemia, Ketosis
- Trial name
- NCT05477368
- Testing
- D-β-hydroxybutyric acid with R-1,3-butanediol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Brain Health
Effects of Acute Ketone Supplementation on the Brain
The purpose of this study is to determine how a ketone ester supplement affects brain function, brain blood flow, and brain metabolism in healthy middle-aged and older adults.
- Trial name
- KETO-BRAIN (NCT07711990)
- Testing
- Ketone Ester Drink
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Christopher Crabtree
Healthy
Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging.
- Trial name
- NCT02410161
- Testing
- alpha-linolenic acid-rich supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketones, Dietary Supplements
Exogenous Ketones and Glucose Tolerance
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source.
- Trial name
- NCT03461068
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Lymphedema, Ketogenic Dieting
Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?
Lymphedema is a debilitating disorder that severely impairs the quality of life of the patients and requires life-long attention. Treatment for lymphatic dysfunction remains largely symptomatic, without real cure.
- Conditions
- Lymphedema, Ketogenic Dieting, Ketone Ester Supplement
- Trial name
- KETOLYMPH (NCT03991897)
- Testing
- Ketogenic diet, Isocaloric diet, Ketone ester supplementation
- Where
- Belgium
- Volunteers
- 81 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Opioid Use Disorder
Ketones for Opioid Craving
The goal of this clinical trial is to learn if ketone supplementation (KS) works to reduce craving for opioids for adults with opioid use disorder (OUD) undergoing in-patient acute withdrawal management.
- Trial name
- NCT07128524
- Testing
- Treatment with Ketone Supplement
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 2, Hyperglycemia
Examining the Feasibility of Prolonged Ketone Concentrate Supplement Drink Consumption in Adults With Type 2 Diabetes
Brief Summary: Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate "keto" diet.
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia, Ketosis
- Trial name
- NCT05983562
- Testing
- Dietary Supplement: D-β-hydroxybutyric acid with R-1,3-butanediol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
COVID-19 Acute Respiratory Distress Syndrome
T-Cell Mitochondrial Respiration Response to Ketone Monoester Supplement in Healthy Volunteers and COVID-19
T-Cell Mitochondrial Respiration Response to Ketone monoester (Ketoneaid) in Healthy Volunteers and COVID-19
- Trial name
- NCT05798260
- Testing
- Agilent Seahorse XF Cell Mito Stress Test
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Acute Alcohol Withdrawal
The goal of this study is to study the effects of the ketone supplement Kenetik compared to placebo (an inactive beverage) on alcohol withdrawal symptoms during the 5 days of clinical alcohol withdrawal management treatment at…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
- Trial name
- NCT06173973
- Testing
- Kenetik; Ketone Concentrate
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Alzheimer's Disease
Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease
Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
- Trial name
- MCT-MA (NCT02709356)
- Testing
- 1-month of 60-40 MCT oil, 1-month of C8 MCT oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketoses, Metabolic, Ketosis
Efficacy of Acute Intake of Ketones on Performance in Professional Road Cyclists
Randomized, controlled, double-blind, crossover clinical trial, depending on the product consumed, to analyze the efficacy on physical performance of a sports supplement consumed prior to and during competition or training.
- Trial name
- KETA (NCT05294939)
- Testing
- Ketone monoester, Control product consumption
- Where
- Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Overweight and Obesity, Cognitive Change
Acute Effects of Exercise Combined With Ketone Ester Supplement
To examine the acute changes in cardiometabolic and neurocognitive outcomes in response to exercise combined with ketone ester supplement in overweight/obese adults.
- Conditions
- Overweight and Obesity, Cognitive Change, Ketoses, Metabolic
- Trial name
- NCT06365957
- Testing
- Ketone monoester supplementation, High-intensity interval exercise, Moderate-intensity continuous exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Macau
Ketosis, Diabetic
Exogenous Ketones in People With Type 1 Diabetes
The aim of this pilot study is to investigate the metabolic effects of exogenous ketone ester food supplements, by assessing the change in blood acid-base balance, and the level of blood beta-hydroxy-butyrate in people with type…
- Trial name
- NCT04487678
- Testing
- Ketone ester supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prediabetic State
Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes
The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes.
- Trial name
- MCT+AE (NCT02678390)
- Testing
- MCT, MCT+ aerobic exercise, Aerobic exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Dietary Supplement: Ketone Supplement, Dietary Supplement: Placebo
The Effects of Exogenous Ketones on Glucose Tolerance
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source.
- Trial name
- NCT04088617
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Mild Cognitive Impairment
Proof of Mechanism of a New Ketogenic Supplement Using Dual Tracer PET (Positron Emission Tomography)
A six month, placebo-controlled, parallel group project in which MCI participants will receive 30 g/day of a custom-made MCT-based ketogenic supplement or a matching placebo.
- Trial name
- BENEFIC (NCT02551419)
- Testing
- ketogenic drink
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Université de Sherbrooke