Clinical trials: Dietary Supplement: Ketone Supplement
Brain Health
Effects of Acute Ketone Supplementation on the Brain
The purpose of this study is to determine how a ketone ester supplement affects brain function, brain blood flow, and brain metabolism in healthy middle-aged and older adults.
- Trial name
- KETO-BRAIN (NCT07711990)
- Testing
- Ketone Ester Drink
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Christopher Crabtree
Exercise, Ketones
The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source.
- Conditions
- Exercise, Ketones, Dietary Supplements
- Trial name
- NCT02825823
- Testing
- Ketone Salt
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Alzheimer's Disease
Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease
Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
- Trial name
- MCT-MA (NCT02709356)
- Testing
- 1-month of 60-40 MCT oil, 1-month of C8 MCT oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Alcohol Drinking
Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers
This is a single blinded, randomized trial to evaluate the immediate subjective and objective effects of alcohol after a dose ketone supplement compared to a placebo in 10 health volunteers.
- Trial name
- NCT05551754
- Testing
- Ketone Supplement, Alcohol Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
COVID-19 Acute Respiratory Distress Syndrome
T-Cell Mitochondrial Respiration Response to Ketone Monoester Supplement in Healthy Volunteers and COVID-19
T-Cell Mitochondrial Respiration Response to Ketone monoester (Ketoneaid) in Healthy Volunteers and COVID-19
- Trial name
- NCT05798260
- Testing
- Agilent Seahorse XF Cell Mito Stress Test
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Ketoses, Metabolic, Ketosis
Efficacy of Acute Intake of Ketones on Performance in Professional Road Cyclists
Randomized, controlled, double-blind, crossover clinical trial, depending on the product consumed, to analyze the efficacy on physical performance of a sports supplement consumed prior to and during competition or training.
- Trial name
- KETA (NCT05294939)
- Testing
- Ketone monoester, Control product consumption
- Where
- Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Healthy
Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging.
- Trial name
- NCT02410161
- Testing
- alpha-linolenic acid-rich supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Opioid Use Disorder
Ketones for Opioid Craving
The goal of this clinical trial is to learn if ketone supplementation (KS) works to reduce craving for opioids for adults with opioid use disorder (OUD) undergoing in-patient acute withdrawal management.
- Trial name
- NCT07128524
- Testing
- Treatment with Ketone Supplement
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Dietary Supplement: Ketone Supplement, Dietary Supplement: Placebo
The Effects of Exogenous Ketones on Glucose Tolerance
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source.
- Trial name
- NCT04088617
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes Mellitus, Type 2, Hyperglycemia
Examining the Feasibility of Prolonged Ketone Concentrate Supplement Drink Consumption in Adults With Type 2 Diabetes
Brief Summary: Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate "keto" diet.
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia, Ketosis
- Trial name
- NCT05983562
- Testing
- Dietary Supplement: D-β-hydroxybutyric acid with R-1,3-butanediol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Ketosis, Diabetic
Exogenous Ketones in People With Type 1 Diabetes
The aim of this pilot study is to investigate the metabolic effects of exogenous ketone ester food supplements, by assessing the change in blood acid-base balance, and the level of blood beta-hydroxy-butyrate in people with type…
- Trial name
- NCT04487678
- Testing
- Ketone ester supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Failure
Physiological Effects Ketone Ester in Heart
The study is aimed to phenotype with cardiac MRI the physiological effects of ketone esters on the heart. Patients with heart failure will be recruited and given ketone esters or placebo in a randomized fashion.
- Trial name
- KEHeart (NCT05924802)
- Testing
- Ketone Ester
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Alzheimer Disease and Related Dementias (ADRD)
Veech Ketone Ester to Support Brain Energy in Mild Cognitive Impairment and Early Alzheimer's Disease
It is projected that by 2030, one in every five Americans will be of retirement age, and this demographic shift is expected to result in more people suffering from dementia.
- Trial name
- NCT06767124
- Testing
- Ketogenic Supplement
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of Pennsylvania
Lymphedema, Ketogenic Dieting
Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?
Lymphedema is a debilitating disorder that severely impairs the quality of life of the patients and requires life-long attention. Treatment for lymphatic dysfunction remains largely symptomatic, without real cure.
- Conditions
- Lymphedema, Ketogenic Dieting, Ketone Ester Supplement
- Trial name
- KETOLYMPH (NCT03991897)
- Testing
- Ketogenic diet, Isocaloric diet, Ketone ester supplementation
- Where
- Belgium
- Volunteers
- 81 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven