Clinical trials: Diffuse Parenchymal Lung Diseases
Pulmonary Fibrosis, Telomere Shortening
The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis
TELO-SCOPE is a national, multi-centre, double-blind, placebo-controlled, randomised (2:1) trial which will test the hypothesis that, compared to placebo, the addition of danazol to standard of care in pulmonary fibrosis…
- Conditions
- Pulmonary Fibrosis, Telomere Shortening, Telomere Disease, Dyskeratosis Congenita
- Trial name
- NCT04638517
- Testing
- Danazol
- Where
- 9 sites in Australia
- Volunteers
- 29 people
- Sponsor
- The University of Queensland
Interstitial Lung Disease, Skeletal Muscle Dysfunction
Assessment of Skeletal Muscle Dysfunction in Patient With Idiopathic Pulmonary Fibrosis
Interstitial lung disease includes a heterogeneous group of chronic lung conditions that is characterized by exertional dyspnoea and poor health related quality of life .
- Trial name
- NCT03440489
- Testing
- Six-minute walking test, 30 seconds chair stand test
- Volunteers
- 1 people
- Sponsor
- Assiut University
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
Family-centred Pulmonary Rehabilitation to Empower Carers
Chronic respiratory diseases are leading causes of death and disability worldwide, imposing an enormous burden on individuals, families, and societies. Dependence on others begins early in the disease course.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial, Asthma, Lung Neoplasms
- Trial name
- CARE2CARER (NCT07791147)
- Testing
- Carer inclusive pulmonary rehabilitation, Pulmonary rehabilitation
- Where
- 7 sites in Portugal
- Volunteers
- 120 people
- Sponsor
- Aveiro University
Interstitial Lung Disease
Clinical Study of 18F-FAPI-RGD in Interstitial Lung Disease Associated With Connective Tissue Disease
The goal of this observational study is to examine clinical utility of 18F-FAPI-RGD PET/CT imaging in evaluating connective tissue disease-associated interstitial lung disease.
- Trial name
- NCT06143540
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sichuan Provincial People's Hospital
Fibrotic Interstitial Lung Disease
High Intensity Interval Training in Fibrotic Interstitial Lung Disease
The fibrotic interstitial lung diseases (fILD) is a group of debilitating chronic lung conditions that are characterised by scarring of lung tissue, dyspnoea on exertion and significant physical impairment.
- Trial name
- HIIT in fILD (NCT03800914)
- Testing
- High intensity interval training, Traditional pulmonary rehabilitation
- Where
- 4 sites in Australia
- Volunteers
- 131 people
- Sponsor
- Monash University
Sarcoidosis, Pulmonary
Diagnostic Value of EBUS-Guided Transbronchial Mediastinal Cryobiopsy Versus Conventional Bronchoscopic Approaches for Stage I/II Sarcoidosis
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and/or transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal…
- Trial name
- NCT07246876
- Testing
- EBUS-TBNA-based sampling methods, EBUS-TBMC based sampling method
- Where
- China
- Volunteers
- 469 people
- Sponsor
- China-Japan Friendship Hospital
Idiopathic Interstitial Pneumonia
Interstitial Pneumonia With Autoimmune Features: Evaluation of Connective Tissue Disease Incidence During Follow-up
Interstitial lung diseases (ILD) represent a frequent complication of connective tissue diseases (CTDs), especially systemic sclerosis, idiopathic inflammatory myopathies and rheumatoid arthritis.
- Trial name
- EVOLIPAF (NCT04179058)
- Testing
- Follow-up
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Interstitial Lung Diseases, Rheumatoid Arthritis
Fibrocytes in Rheumatoid Arthritis, Asthma and Interstitial Lung-disease.
To study Fibrocytes in patients with Rheumatoid Arthritis, Interstitial lung disease and severe asthma and healthy controls.
- Conditions
- Interstitial Lung Diseases, Rheumatoid Arthritis, Asthma
- Trial name
- NCT02711657
- Testing
- Fibrocyte measurement and lung function test.
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Interstitial Lung Disease (ILD)
Acute Hemodynamic Responses to Blood Flow Restriction Aerobic Exercise in Interstitial Lung Disease
Interstitial lung diseases (ILD)impaired gas exchange and reduced lung elasticity lead to marked reductions in exercise capacity and decreased oxygen consumption due to circulatory limitations.
- Trial name
- NCT07315425
- Testing
- Blood flow restriction (BFR) low-intensity aerobic exercise training, Low-intensity aerobic exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Sarcoidosis, Pulmonary
An RCT of NBI vs. White Light Guided Endobronchial Biopsy in Suspected Sarcoidosis
In the diagnosis of patients with sarcoidosis, there is paucity of literature on the diagnostic yield of the endobronchial biopsies obtained with narrow band imaging (NBI) bronchoscopy.
- Trial name
- NABS (NCT05311150)
- Testing
- Narrow band imaging bronchoscopy guided endobronchial biopsy, White light bronchscopy guided endobronchial biopsy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Occupational Diseases, Occupational Lung Disease
Multifaceted Intervention for Protection Against Cotton Dust Exposure Among Textile Workers
Textile workers are exposed to various harmful substances during work, including cotton dust, which is the dust present in air during the handling or processing of cotton.
- Trial name
- MultiTex-RCT (NCT03738202)
- Testing
- Multifaceted intervention package
- Where
- Pakistan
- Volunteers
- 2,031 people
- Sponsor
- Aga Khan University
Vasculitis, Wegener's Granulomatosis
Phase I Trial of Recombinant Human Interleukin-10 (SCH 52000) in Patients With Wegener's Granulomatosis
The purpose of this study is to assess the safety, tolerance, and immunologic effects of interleukin-10 (IL-10), in patients with Wegener's granulomatosis.
- Trial name
- NCT00001761
- Testing
- Interleukin-10
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Idiopathic Pulmonary Fibrosis
Evaluation of the Value of 18F-Fluoromisonidazole (18F-FMISO) Positron Emission Tomography Hypoxia Imaging in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, lethal disease of unknown etiology and with a variable course. There is currently no test in routine care that can assess both the anatomical and functional damage of the…
- Trial name
- FIPOXY (NCT05331729)
- Testing
- FMISO-PET Protocol
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Interstitial Lung Disease
The Effects of Breathing Retraining in Patients With Interstitial Lung Diseases
Breathing retraining has been reported to lead to improvements in dyspnoea and walking distance in chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT03729583
- Testing
- Pulmonary Rehabilitation
- Where
- Malta
- Volunteers
- 30 people
- Sponsor
- University of Malta
Idiopathic Pulmonary Fibrosis
Prospective Study of Fibrosis In the Lung Endpoints (PROFILE - Central England)
The overall aim of this study is to develop a test that predicts the prognosis of IPF (Idiopathic Pulmonary Fibrosis) and which could be used to determine whether new treatments for IPF are likely to work.
- Trial name
- PROFILE (NCT01134822)
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- University of Nottingham
Castleman's Disease (CD), Langerhans Cell Histiocytosis (LCH)
Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms and Castleman Disease
The purpose of this study is to use agnostic genomic evaluation using whole exome sequencing (WES) of a variety of rare hematologic diseases grouped under rare blood diseases and its variants to further elucidate the…
- Conditions
- Castleman's Disease (CD), Langerhans Cell Histiocytosis (LCH), Non-Langerhans-Cell Histiocytosis
- Trial name
- NCT05028621
- Testing
- Genetic testing
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Case Comprehensive Cancer Center
Interstitial Lung Disease
Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD)
To develop a repository of blood samples from patients with ILD to support future studies into the development of such biomarkers. Patients with pneumonia and healthy patients will also be recruited as a control group.
- Trial name
- NCT03478826
- Testing
- ILD, Healthy, Pneumonia
- Where
- United States
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Interstitial Lung Disease
Comparison of Transbronchial, Cryoprobe and VATS Biopsy For the Diagnosis of Interstitial Lung Disease (ILD)
The objective of this study is to compare the sample size, architectural preservation and diagnostic yield of bronchoscopic cryo-probe transbronchial lung biopsy (C-TBBx) to bronchoscopic standard transbronchial lung biopsy…
- Trial name
- NCT01972685
- Testing
- Cryobiopsy biopsy, Transbronchial Biopsy, VATS biopsy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well vemurafenib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with BRAF V600 mutations that have spread to other places in the body…
- Conditions
- Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma, Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma, Ependymoma
- Trial name
- NCT03220035
- Testing
- Laboratory Biomarker Analysis, Vemurafenib
- Where
- 116 sites in United States, Puerto Rico
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Fibrosis
Feasibility Randomised Controlled Trial Exploring Implementation of the Compassionate Mindful rEsilience pRogram for People With pUlmonaRY Fibrosis: The MERcURY Study
Pulmonary fibrosis (PF) is a chronic lung condition in which scar tissue gradually forms, impairing oxygen transfer and causing breathlessness.
- Trial name
- MERcURY (NCT07782060)
- Testing
- Compassionate mindful resilience
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Queen's University, Belfast
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