Clinical trials: Diffusion-weighted MRI
X-linked Adrenoleukodystrophy
Validation of a Prognostic Biomarker Using Brain Diffusion MRI in X-linked Adrenoleukodystrophy
CALD is an inflammatory demyelinating disease that causes severe motor and cognitive deficit leading to rapid death. Hematopoietic stem cell transplantation (HSCT) can halt neuroinflammation in CALD through the replacement of…
- Trial name
- CALDIFF (NCT05911919)
- Testing
- brainQuant module of brainTale-care platform
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pelvic Diseases, Abdominal Diseases
The Study of Functional Magnetic Resonance Imaging in Abdominal and Pelvic Diseases
The purpose of this study is to study the diagnostic efficiency of functional magnetic resonance imaging in Abdominal and Pelvic Diseases.
- Trial name
- NCT02337777
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Arthritis, Juvenile Idiopathic, Enthesitis-Related Arthritis, Juvenile
Juvenile Arthritis Quantitative Imaging
This observational study aims to develop and validate quantitative magnetic resonance imaging biomarkers as measures of disease activity in juvenile idiopathic arthritis (JIA).
- Trial name
- JAQI (NCT02684695)
- Testing
- MRI scan (adolescent spine protocol), MRI scan (whole body protocol)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Breast Neoplasms, Artificial Intelligence (AI)
Non-Contrast Breast MRI Diagnosis and Risk Stratification Using DWI-Generated Synthetic Contrast Enhancement
This study is conducted under the ethics-approved project titled "Artificial Intelligence Solution for Simplifying the Diagnostic Workflow of Breast MRI''.The goal of this observational study is to develop an integrated breast…
- Conditions
- Breast Neoplasms, Artificial Intelligence (AI), Magnetic Resonance Imaging (MRI), Diffusion Magnetic Resonance Imaging
- Trial name
- NCT07598084
- Testing
- Non-contrast breast MRI diagnostic model
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Breast Cancer
Quantitative Methods for Supplementing Contrast-Enhanced Magnetic Resonance Imaging of Breast Cancer
Contrast-enhanced magnetic resonance imaging (CE-MRI) is now established as the most accurate non-invasive imaging modality for characterizing breast cancer.
- Trial name
- NCT02058758
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alzheimer's Disease
Diffusion Tensor Weighted MRI in Alzheimer's Disease Modifying Treatment Effects of Galantamine (Reminyl®)
Alzheimer's disease (AD) is characterized by progressive subcortical and cortical neuronal degeneration. AD patients differ in the time course of neuronal degeneration and accompanying cognitive decline.
- Trial name
- NCT00523666
- Testing
- Galantamine (Reminyl®)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Head and Neck Cancer
Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma
Chemo-radiotherapy (CRT) is currently the cornerstone in the management of locoregional advanced head and neck cancer (HNC). Optimization of the quality of RT is therefore an important issue, if the investigators want to improve…
- Trial name
- NCT01827709
- Testing
- A polymerase chain reaction -based hypoxia classifier, Functional imaging before treatment., Immunohistochemical staining
- Where
- Belgium
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Head and Neck Cancer
Magnetic Resonance Imaging (MRI) in the Assessment of Head and Neck Squamous Cell Carcinoma (HNSCC) Response
The purpose of this study is to see if new techniques of measuring HNSCC tumors with magnetic resonance imaging (MRI) can help predict how well the tumors will respond to combined chemotherapy and radiation treatment.
- Trial name
- NCT00994201
- Testing
- DCE-MRI, DW-MRI and MRS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Healthy Participants
Dopamine and Brain Computer Interface
The use of Brain-Computer Interface system (BCI system) allows for the detection of neurophysiological signals on the surface of the head and provides feedback to subjects or patients.
- Trial name
- BCI_LDOPA (NCT06729658)
- Testing
- Madopar
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Alzheimer's Disease
MRI to Measure Treatment With Antibiotics in Alzheimer's Disease
Objectives: To study the changes in brain structure and function using MRI scans in patients treated for Alzheimer's disease. Methods: A pilot study of treating Alzheimer's disease with antibiotics showed some promise that this…
- Trial name
- DARAD-MRI (NCT00692588)
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Glioma Tumor Recurrence, Radiation Necrosis
Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis
This study will examine the use of a variation of standard magnetic resonance imaging (MRI) called diffusion tensor MRI (DT-MRI) for distinguishing injured brain tissue due to radiation therapy (radiation necrosis) from the…
- Conditions
- Glioma Tumor Recurrence, Radiation Necrosis, Primary Brain Tumor
- Trial name
- NCT00285324
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pancreatic Adenocarcinoma
Prospective Evaluation of MRI Biomarkers in Pancreatic Ductal Adenocarcinoma
This is a prospective cohort study in participants with pancreatic adenocarcinoma who are undergoing surgical resection. Participants will have up to two magnetic resonance imaging (MRI) scans with and without intravenous…
- Trial name
- NCT02775786
- Testing
- MRIs with and without intravenous contrast (up to 2)
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Columbia University
Multiple Sclerosis
The Energetic Origin of Neurodegeneration in MS
In multiple sclerosis (MS), the sequence of events leading to irreversible neuro-axonal degeneration, which is a major determinant of clinical disability, is poorly understood.
- Trial name
- ENERGYSEP (NCT04532944)
- Testing
- imaging of energy dysfunction
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Breast Cancer
Breast Cancer Screening With Diffusion-weighted MRI in Women at High Risk for Breast Cancer
A prospective observational multicenter study to compare the outcome of breast cancer surveillance using mammography, breast US, contrast-enhanced MRI, and diffusion-weighted MR imaging (DWI) as a screening tool, in the high-risk…
- Trial name
- NCT03835897
- Where
- South Korea
- Volunteers
- 890 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Abdominal Imaging
Diffusion MRI of the Abdomen
The purpose of this research is to see if a new magnetic resonance imaging (MRI) method will be able to improve the images taken of the abdomen.
- Trial name
- NCT05261633
- Testing
- Diffusion Weighted Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
HIV Infections
MR Imaging and MR Spectroscopy of HIV
The Center for Disease Control and Prevention estimates that 1,148,200 Americans aged 13 years and older are living with HIV infection, including 207,600 (18.1%) who are unaware of their infection.
- Trial name
- HIV (NCT05219279)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Parkinson Disease
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04472325
- Where
- Taiwan
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson Disease (PD), Paralysis; Supranuclear
Progression of Striatal and Extrastriatal Degeneration in PD and PSP Patients
This longitudinal study aims to research cognitive and gait phenotypes of Parkinson's disease and Supranuclear Palsy as well as to provide markers to track diseases progression using a multi-modality approach based on 3D-gait…
- Trial name
- PARKONTHEWAY (NCT03840252)
- Testing
- 3D gait analysis, rsfMRI, Montreal Cognitive assesment (MoCA)
- Where
- Italy
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Prostate Cancer
Evaluation of Rapid T2-weighted and DWI MR Sequences Reconstructed by Deep Learning for Prostate Imaging
MR prostate exam is essential for the diagnosis, workup and follow-up of prostate cancer. It allows to detect subclinical prostate cancer following an increase in the level of PSA.
- Trial name
- DLRPRO (NCT06094322)
- Testing
- MR prostate exam
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cervical Spondylotic Myelopathy
Diffusion MRI in Cervical Spondylotic Myelopathy
diffusion MRI in evaluates and predicts prognosis in CSM
- Trial name
- NCT04952831
- Testing
- diffusion MRI (dMRI)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital