Clinical trials: Diffusion-weighted MRI
Uterine Neoplasms
MRI and Metabolomics Biomarkers for Uterine Malignancy
The aims of this project are: (1) To establish a research platform in order to integrate multiparametric imaging and metabolomics data for uterine malignancy.
- Trial name
- EMCAMRS (NCT02528864)
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Traumatic Brain Injury
Predicting Cognitive and Emotional Health From Neurocircuitry Following TBI
Abnormalities in structural and functional connectivity between brain regions have been suggested as putative biomarkers of mild traumatic brain injury (TBI) and significant contributors to neuropsychological functioning and…
- Trial name
- NCT01803048
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Arizona
MR Image Distortion Correction, Prostate Cancer
UNDISTORT Correction of Distortions in Diffusion MRI V1.0
This is a three-year project funded by a Cancer Research UK Multidisciplinary Award and brings together a team from UCL Division of Medicine, Computer Science and University College London Hospital.
- Trial name
- UNDISTORT (NCT03151512)
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University College, London
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Masticatory Myofascial Pain Syndrome
Diffusion MRI for Quantitative Assessment of Myofascial Pain
The purpose of this study is to assess the diagnostic accuracy of diffusion MRI for evaluation of the jaw muscles for patients with masticatory myofascial pain syndrome.
- Trial name
- NCT06892041
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Breast LN
Comparative Evaluation of Diffusion Weighted MRI And Ultrasonography In The Detection of Breast Lesions
This study aims to conduct a comparative evaluation of Diffusion Weighted MRI (DW-MRI) and Ultrasonography (US) in detecting breast lesions.
- Trial name
- NCT06744101
- Testing
- Evaluate the effectiveness of Diffusion Weighted MRI (DWI) in detecting breast lesions., Compare Sensitivity and Specificity of DWI and USG
- Where
- Pakistan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Superior University
Thorax Cancer
Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions
The purpose of this study, is to investigate the value of diffusion weighted imaging on the differential diagnosis of solitary pulmonary lesions.
- Trial name
- DWIMRICSPL (NCT02482181)
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- ÇAĞLAYAN ÇAKIR
Crohn Disease, Bowel Cleansing
DWI MR-enterography Without or With Bowel Cleansing to Assess Intestinal Inflammatory Activity in the Follow-up of Crohn's Disease
Since 2009, many studies tend to prove the effectiveness of diffusion-weighted MR-enterography in the assessment of inflammatory activity in IBD compared to standard MR-enterography, with the emergence of new radiological scores…
- Conditions
- Crohn Disease, Bowel Cleansing, Apparent Diffusion Coefficient
- Trial name
- ENTEDIF (NCT05354609)
- Testing
- MR-enterography
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Brain Activity, Glucose Control
Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli
The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short…
- Trial name
- NCT02969330
- Testing
- Stimulator, Glucose
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Rectum Cancer, Pelvic Cancer
Assessment of DW-MRI Measures : Reproducibility and Repeatability in Pelvic Imaging on MR-Linac With Healthy Volunteers
This study evaluates the reliability of functional MRI measurements in pelvic disease through quantifying repeatability and reproducibility, using healthy volunteers.
- Trial name
- PILLAR (NCT06458725)
- Testing
- Magnetic Resonance Imaging (MRI)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jules Bordet Institute
Brain Aging
Synaptic Plasticity Imaging With Diffusion MRI
Diffusion MRI employed in functional imaging has the potential to probe directly brain activation instead of blood changes like the BOLD technique.
- Trial name
- NCT01686516
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Gastric Cancer
Study on the Value of Three DWI Scanning Sequences in Staging of Gastric Cancer
Accurate staging is critical for effective gastric cancer treatment planning. Conventional DWI (C-DWI) has limitations in image quality due to magnetic field inhomogeneity, which hampers precise T staging.
- Trial name
- NCT06735105
- Testing
- Scanning parameter
- Where
- China
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Yunnan Cancer Hospital
Carpal Tunnel Syndrome, Neurodynamic Treatment
Mechanisms of Neurodynamic Treatments
INTRODUCTION: Carpal tunnel syndrome (CTS) is a relatively common condition caused by compression of one of the main nerves at the wrist, the median nerve.
- Conditions
- Carpal Tunnel Syndrome, Neurodynamic Treatment, Nerve Mobilisation, Diffusion MRI
- Trial name
- MONET (NCT05859412)
- Testing
- Neurodynamic exercises, Steroid injection (Depomedrone 40mg), Advice
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Drunk Driving
Leveraging Transdermal Alcohol Monitoring to Reduce Drinking Among DWI Defendants
The current study will evaluate the efficacy of contingency management (i.e., reinforcement for avoiding heavy drinking) among adults arrested for drunk driving and who are at risk for ongoing heavy drinking.
- Trial name
- NCT03638596
- Testing
- Contingency Management, Control
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Brain MRI
Variability of Cerebral MRI Diffusion Parameters by Using a Patented Normalization Process vs no Use
BrainTale has developed a standardization approach based on averaging measurements in predefined brain regions of interest and use of reference data acquired from healthy volunteers under conditions (MRI machine, acquisition…
- Trial name
- CALI (NCT05446922)
- Testing
- Diffusion MRI
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Braintale
Alzheimer's Disease
Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI
Investigators propose in this study to evaluate prospective memory (MP) in all its complexity as well as the processes, cognitive and brain, the underlying.
- Trial name
- IMPRO (NCT02522091)
- Testing
- functional brain MRI, Neuropsychology tests
- Where
- France
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Huntington Disease
Accelerated Diffusion MRI for Diagnosis of Hungtington Disease
The hypotheses of the project are 1. Diffusion MRI using compressed sensing could have reduced motion sensitivity and improved susceptibility related artifact because of accelerated acquisition. 2.
- Trial name
- NCT01884181
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wang . Jiun-Jie
Ischemic Optic Neuropathy, Optic Neuritis
Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.
The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging
- Conditions
- Ischemic Optic Neuropathy, Optic Neuritis, Compressive Optic Neuropathy, Traumatic Optic Neuropathy
- Trial name
- NCT05353413
- Testing
- Neuroimaging, VEP - visual evoked potential, Ophthalmology examination.
- Where
- Poland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Stroke
Understanding Motor Function in Stroke Patients and Their Functional Brain Reorganization Using Ultra High-field MRI
The MOTIF-STROKE study is embedded within the BrainSync project, aiming to develop innovative strategies for motor rehabilitation of the upper limb.
- Trial name
- MOTIF-STROKE (NCT07339813)
- Testing
- Functional MRI (fMRI) Acquisition
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Commissariat A L'energie Atomique
Myeloma
Machine Learning in Myeloma Response
Diffusion-weighted Whole Body Magnetic Resonance Imaging (WB-MRI) is a new technique that builds on existing Magnetic Resonance Imaging (MRI) technology.
- Trial name
- MALIMAR (NCT03574454)
- Testing
- Machine Learning (ML)
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust