Clinical trials: Digestive Neoplasms
Gallbladder Cancer
Predicting Incidental Gallbladder Cancer
The goal of this observational study is to identify risks factors for incidental (unexpected) gallbladder cancer in adult patients undergoing routine gallbladder surgery (cholecystectomy) for conditions such as gallstones or…
- Trial name
- P-iGBC (NCT06531408)
- Where
- United Kingdom
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Crohn's Disease, Rheumatoid Arthritis
OTIS Cimzia Pregnancy Registry
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Crohn's Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01797224
- Where
- United States
- Volunteers
- 925 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Colorectal Cancer
Attitudes Towards Prophylactic Colectomy in Hereditary Non-polyposis Colorectal Cancer (HNPCC) Patients
The purpose of this study is to learn more about individual's with a family history of colon cancer and the process by which they may decide to undergo or not undergo prophylactic colectomy.
- Trial name
- NCT00582452
- Testing
- Telephone survey
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Solid Tumor Malignancies, Hematologic Cancer
The Application of 18F-G1 PET/CT Targeting Granzyme B in the Pan-cancer Immunotherapy
The purpose of this study is to explore the effectiveness of 18F-G1 PET/CT in patients with solid tumors and hematological malignancies receiving immunotherapy
- Conditions
- Solid Tumor Malignancies, Hematologic Cancer, Lung Cancer, Esophagus Cancer
- Trial name
- NCT07039474
- Testing
- 18F-G1
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Diabetes Risk, CVD Risk
Effectiveness of a Self-health Assessment Mobile Application in Young-to-midlife Adults in Hong Kong
This project aims to compare the effectiveness of Wellnuts, an evidence-based, algorithm-driven self-health assessment mobile application, in empowering asymptomatic young-to-midlife adults in Hong Kong, promoting health…
- Conditions
- Diabetes Risk, CVD Risk, Colorectal Cancer, Lung Cancer
- Trial name
- NCT07720245
- Testing
- Wellnuts app intervention, Web-based health resources
- Where
- Hong Kong
- Volunteers
- 574 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Lynch Syndrome, Li Fraumeni Syndrome
Video Capsule Examination in Patients With Lynch Syndrome
Surveillance for colorectal cancer (CRC) in patients predisposed to develop CRC during their lifetime has been impacted by access to colonoscopy suites and endoscopy specialists in the past couple of years.
- Conditions
- Lynch Syndrome, Li Fraumeni Syndrome, PTEN Hamartoma Syndrome, FAP
- Trial name
- PILLCAM (NCT06712095)
- Testing
- Video capsule investigation
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Colonic Polyps, Colorectal Neoplasms
Right Colon Enema to Improve Bowel Preparation Quality During Colonoscopy
Colonoscopy is a test that lets doctors look inside the large bowel to find and remove growths called polyps, which can develop into bowel cancer. Before the test, people take a bowel preparation to empty the bowel.
- Conditions
- Colonic Polyps, Colorectal Neoplasms, Colonoscopy, Bowel Preparation Quality
- Trial name
- RIGHT-CLEAN (NCT07813013)
- Testing
- Sodium phosphate enema, Water instillation
- Where
- 2 sites in Australia
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Westmead Hospital
Dietary Habits
Dietary Factors and Risk of Gallbladder Carcinoma in China
The purpose of this study is to see how people's diets, other aspects of their lifestyles affect their chances of getting gallbladder carcinoma in China.
- Trial name
- DRGBC001 (NCT03546296)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yingbin Liu, MD, PhD, FACS
Colorectal Cancer
Difference of Surgical Site Infection Between Using Sodium Picosulfate Solution(PicosolutionⓇ) and Oral Sulfate Tablet(ORA·FANGⓇ) in Colorectal Cancer Surgery
This is a prospective randomized study to evaluate the difference in the rate of surgical site infection between the patients who used Sodium Picosulfate solution(PicosolutionⓇ) and tablet Oral Sulphate Solution(ORA·FANGⓇ) for…
- Trial name
- NCT04593446
- Testing
- Oral Sulfate Tablet(ORA·FANGⓇ), Sodium Picosulfate Solution(PicosolutionⓇ)
- Where
- South Korea
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Colorectal Cancer
Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay
Epigenomics is developing a colon cancer screening assay based on differential methylation of specific CpG sites for the detection of early stage disease.
- Trial name
- NCT00696345
- Where
- 5 sites in Germany, Hungary
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Colorectal Cancer
Lifestyle Intervention After Colonoscopy (LIFE-SCREEN Pilot)
The study aims to evaluate the impact of promoting advice on the latest evidence-based diet and lifestyle recommendations for cancer prevention at colorectal cancer (CRC) screening among individuals who may be at higher risk for…
- Trial name
- NCT05273931
- Testing
- Lifestyle intervention
- Where
- 2 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre Leon Berard
Gastric Cancer
Gastric Cancer Registry for Epidemiology and Molecular Risk Factor
This study is a multi-center, prospective cohort study which are planned to enroll the 2,500 patients who diagnosed the primary gastric cancer and 5,000 healthy normal cohort participants for 5 years.
- Trial name
- NCT03046745
- Where
- South Korea
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Colorectal Neoplasms
FIT Mailing Protocol-For Cancer Screening Navigation
We plan to study whether the impact of offering the choice of a pre-colonoscopy physician visit or direct referral to colonoscopy will increase adherence to colonoscopy relative to usual care in a large fecal immunochemical test…
- Trial name
- NCT02934958
- Testing
- Colon Cancer Screening Navigation, Standard of Care
- Where
- United States
- Volunteers
- 13,392 people, healthy volunteers welcome
- Sponsor
- Renown Regional Medical Center
Colorectal Cancer
Vitamin D, Genes and Colorectal Cancer
The aim of this study is to investigate the interaction between intake of vitamin D and polymorphisms in GC and CYP2R1 in relation to risk of colorectal cancer in a Danish prospective cohort study.
- Trial name
- NCT03370432
- Testing
- Observational
- Volunteers
- 2,895 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Colo-rectal Cancer
Comparison of Ultrasound-guided Erector Spinae Plane Block and Transmuscular Quadratus Lumborum Block
The objective of this study is to compare the postoperative analgesic effect of bupivacaine injection via ultrasound-guided erector spinae block versus transmuscular quadratus lumborum block in patients undergoing abdominal…
- Trial name
- NCT05709899
- Testing
- nerve blocks
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Assiut University
Esophageal Cancer, Bile Duct Neoplasms
Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract
Doctors at Memorial Sloan Kettering Cancer Center and at other institutions study normal and cancer cells. To study these cells we need to have human tissue, body fluids, and blood.
- Conditions
- Esophageal Cancer, Bile Duct Neoplasms, Gastric Cancer, Liver Cancer
- Trial name
- NCT00582647
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hepatocellular Carcinoma
A Novel Immunotherapy PD-1 Antiboty to Suppress Recurrence of HCC Combined With PVTT After Hepatic Resection
Hepatic resection is the most effective curative treatment for resectable HCC, whereas frequent recurrence usually impaired the efficacy of hepatic resection and contributed poor survivals.
- Trial name
- NCT03914352
- Testing
- PD-1 antibody, TACE
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cancer Hospital of Guangxi Medical University
Appendix Cancer, Appendiceal Cancer
Genetics of Appendix Cancer Study
The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.
- Conditions
- Appendix Cancer, Appendiceal Cancer, Appendiceal Neoplasms, Appendiceal Mucinous Neoplasm
- Trial name
- GAP (NCT05734430)
- Testing
- Genetic profiling, Retrospective tissue procurement
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Andreana Holowatyj, PhD, MSCI
Colo-rectal Cancer
Decision Counseling and Follow-up for Shield+ Patients
Prospective, observational, minimal-risk study evaluating decision-making, decisional conflict, intention to undergo complete diagnostic evaluation (CDE), and colonoscopy completion after a positive Shield TM blood-based…
- Trial name
- DCaF (NCT07620535)
- Testing
- Decision Counseling Session
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Guardant Health, Inc.
Colorectal Cancer
Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults
Although dietary vitamin D supplementation has been used in the clinical setting for decades, the effect of supplementary vitamin D consumption on the structure of the microbiome has not been studied in humans in fine scale or…
- Trial name
- VDMT (NCT05387876)
- Testing
- Vitamin D intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Baylor University
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