Clinical trials: Digestive System Diseases
Insomnia, GERD
Sleep Disorders and Gastroesophageal Reflux Disease (GERD)
This study will investigate Gastroesophageal Reflux Disease (GERD)as a cause of sleep disturbance. Patients with GERD may experience all or some of the following symptoms: stomach acid or partially digested food re-entering the…
- Trial name
- NCT00287391
- Testing
- Rabeprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Hepatocellular Carcinoma
GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma
This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma.
- Trial name
- NCT05047510
- Testing
- Anti-GPC3-IRDye800CW
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Cystic Fibrosis
Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis
In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this…
- Trial name
- NCT06163482
- Testing
- Mixed meal
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Hepatitis B
Hepatitis B Seroepidemiology Among Young Adults
Taiwan has launched a successful nationwide neonatal hepatitis B immunization since July 1, 1984. It successfully decreased the incidence of hepatitis B virus infection, the hepatitis B carrier rate as well as liver diseases…
- Trial name
- NCT01973582
- Where
- Taiwan
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gastrointestinal Neoplasms, Bronchial Carcinoma
Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training
The purpose of the study is to tests the hypothesis, that N-acetylcysteine (a thiol-antioxidant)improves the exercise training effect on cancer patients that experience weight loss (cachexia) as assessed by muscle mass and…
- Conditions
- Gastrointestinal Neoplasms, Bronchial Carcinoma, Hodgkin Disease, Non-Hodgkin Lymphoma
- Trial name
- NCT00196885
- Testing
- N-acetylcysteine
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Diarrhea, Gastrointestinal Infection
Wells and Enteric Disease Transmission
Approximately 40 million people in the US are served by private, and frequently untreated, wells. Our best estimate is that 1.3 million cases of gastrointestinal illnesses (GI) per year are attributed to consuming water from…
- Conditions
- Diarrhea, Gastrointestinal Infection, Respiratory Viral Infection, Waterborne Diseases
- Trial name
- WET (NCT04826991)
- Testing
- Active UV Device, Inactive UV Device
- Where
- United States
- Volunteers
- 908 people, healthy volunteers welcome
- Sponsor
- Temple University
Gastric Cancer, H Pylori Infection
H. Pylori Screen-and-treat Study in a Population of Young Adults
Gastric cancer remains a major challenge to public health on a global scale. H. pylori related cancer burden contributes to the largest proportion of cancer cases attributable to infections in Europe.
- Conditions
- Gastric Cancer, H Pylori Infection, H Pylori Eradication, H-pylori
- Trial name
- NCT06275204
- Testing
- Bismuth-based quadruple therapy, Levofloxacin-based quadruple therapy, Standard triple therapy
- Where
- 7 sites in Croatia, Ireland and 4 more
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Barrett's Esophagus
Prospective Study to Compare the Efficacy of E.G.Scan to Detect Barrett's Esophagus Compared With Standard Endoscopy
The purpose of this study was to evaluate whether a disposable nasal endoscope called "E.G. Scan II" will visualize the esophagus as well as the standard test, sedated endoscopy.
- Trial name
- NCT02066233
- Testing
- EG Scan II (transnasal endoscopy), Standard Endoscopy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Erythropoietic Protoporphyria
Sorbent Therapy of the Cutaneous Porphyrias
The investigators demonstrated that cholestyramine is an effective binding agent in vitro for porphyrins. A few isolated case reports of treatment of individuals with a cutaneous porphyria suggest that cholestyramine and…
- Trial name
- EPP (NCT01422915)
- Testing
- Colestipol
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Crohn's Disease, Ulcerative Colitis
Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease
Breastfeeding is beneficial to both mother and baby. However, many breastfeeding women are affected by long-term health conditions and need to take medications.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Healthy Controls
- Trial name
- NCT03397108
- Testing
- The IBD group was divided into 2 subgroups: with or without anti-TNF antibody use
- Where
- 2 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Hepatitis B
Study to Compare the Efficacy of GSK Biologicals' Adjuvants in Combination With the Antigen of the Hepatitis B Vaccine
The aim of this Observer-blind study is to compare different Adjuvant Systems with the same, well-known antigen (HBsAg) already used in the GSK marketed vaccines against Hepatitis B (Engerix-BTM and FendrixTM), in order to better…
- Trial name
- NCT00805389
- Testing
- Engerix-B™, Fendrix™, GSK Biologicals' Hepatitis B vaccines (GSK223192A)
- Where
- 14 sites in Belgium, Germany
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lung Neoplasms, Neoplasm Metastasis
Mediastinal Lymph Node Dissection in Conjunction With Pulmonary Metastasectomy From Colorectal Cancer
To study whether or not total mediastinal lymph node dissection in conjunction with pulmonary metastasectomy from colorectal cancer is associated with improved survival compared to pulmonary metastasectomy only.
- Conditions
- Lung Neoplasms, Neoplasm Metastasis, Colorectal Cancer
- Trial name
- NCT03113318
- Testing
- Total mediastinal lymph node dissection and pulmonary metastasectomy, Only pulmonary metastasectomy
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hepatitis B, HIV
Integrating Hepatitis B Elimination Into the HIV Program in Zambia
The goal of this study is to develop an integrated HBV-HIV service care model in Zambia by working with people living with HBV, healthcare workers, policy makers and other key stakeholders to co-design an intervention.
- Conditions
- Hepatitis B, HIV, Implementation Science
- Trial name
- INTEGRATE B (NCT07875218)
- Testing
- Integrated HBV/HIV Service Delivery Model
- Where
- Zambia
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Urothelial Carcinoma, Lynch Syndrome
Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)
Lynch syndrome (LS) is an inherited cancer predisposition syndrome caused by pathogenic germline variants in DNA mismatch repair (MMR) genes.
- Trial name
- NCT06218433
- Testing
- Urothelial cancer screening using urine tumor DNA test, Urothelial cancer screening using urine cytology (comparator)
- Where
- 2 sites in Canada, Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Portal Hypertension
Clinical,Endoscopic and Radiological Assessment of Portal Hypertension in Children With Chronic Liver Diseases
Portal hypertension is a significant cause of morbidity and mortality in children with chronic liver disease and portal vein obstruction.
- Trial name
- NCT06097715
- Testing
- upper gastrointestinal endoscopy, 1- Complete blood count 2- Coagulation profile
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hepatitis C
Surveillance and Treatment of Prisoners With Hepatitis C
The purpose of the study is to assess how feasible it is to treat and prevent the transmission of Hepatitis C in the prison setting to achieve substantial reductions in the incidence and prevalence of Hepatitis C.
- Trial name
- SToP-C (NCT02064049)
- Testing
- Sofosbuvir/velpatasvir
- Where
- 4 sites in Australia
- Volunteers
- 3,692 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Bowel Obstruction, Artificial Intelligence
Deep Learning-based Artificial Intelligence for the Diagnosis of Small Bowel Obstruction
The study will compare the diagnostic accuracy and time to diagnosis of computed tomography images of patients with suspected intestinal obstruction seen in the emergency room by residents and surgeons, with and without…
- Trial name
- NCT06481358
- Testing
- Artificial intelligence
- Where
- Japan
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Hepatocellular Carcinoma
Clinical Study Examining the Safety and Efficacy of Doxorubicin Drug Eluting Microspheres Transarterial Embolization in the Setting of Hepatocellular Carcinoma (HCC)
The study is designed to determine whether loading doxorubicin (a type of chemotherapy), when loaded onto a drug eluting microsphere will result in increased destruction of a tumor.
- Trial name
- NCT01116635
- Testing
- doxorubicin, superabsorbent polymer microspheres, embolotherapy
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cystic Fibrosis (CF), Cardiorespiratory Fitness
Assessment of Static and Dynamic Inspiratory Muscle Strength and Cardiorespiratory Fitness in Adults With Cystic Fibrosis
This study aims to examine and compare static and dynamic inspiratory muscle strength and cardiorespiratory fitness in adults with cystic fibrosis and their healthy peers.
- Conditions
- Cystic Fibrosis (CF), Cardiorespiratory Fitness, Inspiratory Muscle Strength
- Trial name
- NCT07895108
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hepatitis C, Chronic
Pharmacokinetics of IDX719 in Participants With Normal and Impaired Hepatic Function (MK-1894-008)
The purpose of this study is to evaluate the pharmacokinetics (PK) and safety and tolerability of single-dose administration of IDX719 in participants with normal hepatic function and participants with varying degrees of hepatic…
- Trial name
- NCT01919125
- Testing
- IDX719
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.