Clinical trials: Digestive System Fistula
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Saleh's Technique for Pancreaticojejunostomy (Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate)
This study investigates the safety and efficacy of injecting N-butyl-2-cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the pancreaticojejunostomy (PJ)…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07132541)
- Testing
- Pancreatic parenchymal injection of N-butyl-2-cyanoacrylate(Histoacryl®)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Perianal Fistula, Crohn Disease
Treatment of Perianal Disease Using Adipose-derived Stem Cells
This study will compare healing and surgical outcomes in patients with chronic perianal disease treated with Adipose-derived Stem Cells (ASCs) to outcomes in patients treated in traditional surgical techniques without ASCs.
- Trial name
- NCT03913572
- Testing
- Injection of adipose-derived stem cells into perianal fistula
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Pancreatic Carcinoma, Pancreatic Neoplasm
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula
This phase III trial compares the effect of using lanreotide before surgery to surgery alone in preventing pancreatic fistulas in patients with pancreatic cancer or a pancreatic lesion that could become cancerous.
- Trial name
- NCT06807437
- Testing
- Biospecimen Collection, Distal Pancreatectomy, Lanreotide
- Where
- 118 sites in United States
- Volunteers
- 274 people
- Sponsor
- SWOG Cancer Research Network
Fistula in Ano
Long Term Outcomes After Surgery for Anal Fistula
Anal fistula is a common condition with a wide variety of clinical presentations, which can make evaluation and treatment challenging and surgical outcomes uncertain.
- Trial name
- NCT04588701
- Testing
- surgical procedures commonly done for anal fistula
- Volunteers
- 483 people
- Sponsor
- University of Michigan
Colovesical Fistula
Early Foley Catheter Removal After Diverticular Colovesical Fistula Repair
Patients undergoing surgical repair of colovesical fistula will have have "early" (post-operative day 3) cystogram and removal of bladder catheter.
- Trial name
- NCT05235204
- Testing
- Removal of Foley Catheter 2 to 3 days post Colovesical Fistula (CVF) repair surgery
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Karim Alavi
Ampullary Cancer, Bile Duct Cancer
Modified vs Conventional Blumgart Anastomosis of LPD for the Effects of Pancreatic Fistula of Periampullary Carcinoma
The incidence rate and mortality rate of periampullary cancer at home and abroad both show an increasing trend, seriously affecting the health level of the people.
- Conditions
- Ampullary Cancer, Bile Duct Cancer, Pancreas Cancer, Duodenum Cancer
- Trial name
- NCT06076252
- Testing
- Modified Blumgart Anastomosis in LPD, conventional Blumgart anastomosis in LPD
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Anal Fistulas, Rectal Fistulas
A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas
The study is designed as a prospective, non-randomized clinical trial comparing safety and effectiveness of the CuraSeal PICS-AF device to historical data from commercially available devices for the treatment of anorectal…
- Trial name
- NCT02456324
- Testing
- PICS-AF Device, Historical Controls Treated with Commercially Available Fistula Plugs
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Curaseal Inc.
Pancreaticoduodenectomy
Early POstoperative BIomarkers in PancreatoDuodenectomy: a Spanish Nationwide Study
AIMS: To recruit a large nationwide Spanish series in order to register PF rate and other common morbidity after PD, and to perform external validation of the aforementioned score, as well as to analyze other postoperative blood…
- Trial name
- EPOBIPD (NCT04342923)
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 525 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Pancreatic Fistula
Technical Strategies for Pancreatic Fistula Prevention After Pancreaticoduodenectomy in High-risk Pancreatic Remnant
This trial will investigate what surgical technique between pancreaticogastrostomy and pancreaticojejunostomy with transanastomotic externalized drains is associated with the lowest rate of pancreatic fistula after…
- Trial name
- PREP (NCT03212196)
- Testing
- Pancreaticogastrostomy with external drain, Pancreaticojejunostomy with transanastomotic drain
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Fistula in Ano, Transsphincteric Anal Fistula
Treatment of Fistula in Ano With Autologous Fatty Tissue Cells Transplantation
This is a prospective interventional study on the treatment of transsphincteric fistula in ano. After abdominal or thigh liposuction, fat was injected around the fistula tract that was then transected percutaneously with a sharp…
- Trial name
- NCT04660903
- Testing
- Autologous fat cell transplantation
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Konstantinos Tsimogiannis
Pancreatic Fistula
Role of Preoperative Multislice Computed Tomography in Whipple's Operation.
Preoperative assessment of visceral fat volume(VFV),total fat volume(TFV),pancreas/spleen density ratio and pancreatic duct diameter by multislice computed tomography abdomen to predict the risk of pancreatic fistula after…
- Trial name
- NCT04582461
- Testing
- multislice computed tomography
- Volunteers
- 100 people
- Sponsor
- Assiut University
Periampullary Cancer, Pancreatic Fistula
Complication of Pancreatic Fistula and Bleeding After Pancreaticoduodenectomy in Treatment Periampullary Cancer
This multi-site study will be done across Hepatobiliary and Pancreatic Surgery Department at Cho Ray Hospital and University and Pharmacy Center.
- Conditions
- Periampullary Cancer, Pancreatic Fistula, Bleeding
- Trial name
- PF (NCT04985071)
- Testing
- Pancreaticoduodenectomy
- Where
- Vietnam
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Vo Truong Quoc
Pancreatic Cancer
Placebo Controlled Trial of SOM230 for the Reduction of Post-Pancreatectomy Fistula, Leak, and Abscess
The purpose of this study is to help us learn more about how to lower the patient's risk of the most common complications after their pancreas operation.
- Trial name
- NCT00994110
- Testing
- Pasireotide (SOM230)
- Where
- United States
- Volunteers
- 439 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Anal Fistula, Anal Abscess
Oral Antibiotics for Anal Abscess
BACKGROUND Anal abscess and perianal fistula is a high prevalence disorder in general population that affect adult patients on young ages, affecting them significantly their social and quality of life.
- Trial name
- OFF (NCT03643198)
- Testing
- ANTIBIOTIC (METRONIDAZOLE AND CIPROFLOXACIN), CONTROL
- Where
- Spain
- Volunteers
- 210 people
- Sponsor
- Germans Trias i Pujol Hospital
Esophageal Strictures, Esophageal Leak
Esophageal Stent Migration With Endoscopic Suture Fixation Compared to Standard Deployment
Esophageal stents are commonly used for benign esophageal pathology, especially strictures or esophageal mucosal defects such as leaks, fistulae, or perforations.
- Conditions
- Esophageal Strictures, Esophageal Leak, Esophageal Perforation, Esophageal Fistula
- Trial name
- NCT02751333
- Testing
- FCSEMS with Endostitch (ES), FCSEMS with No Suturing (NS), Fully Covered Self-Expanding Metal Stents (FCSEMS)
- Where
- United States
- Sponsor
- Johns Hopkins University
Pancreatic Fistula
Evaluation of a Novel Pancreaticojejunostomy Technique for Pancreaticoduodenectomy
Pancreaticoduodenectomy is a surgical procedure for removing cancer in the pancreas, the bile system or the duodenum that is associated with a high rate of complications.
- Trial name
- NCT01696903
- Testing
- Pancreaticojejunostomy technique
- Where
- 2 sites in Sweden
- Volunteers
- 123 people
- Sponsor
- Karolinska Institutet
Pancreas Cancer, Fistula
Study Assessing the Effect of Transpapillary Pancreas Duct Stent in Resection of the Pancreatic Tail
Randomized study assessing the effect of transpapillary pancreas duct stent in resection of the pancreatic tail.
- Trial name
- NCT00500968
- Testing
- stent, Distal pancreatectomy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Disease of Pancreatic or Periampullary Lesions
PoLyglycolic Acid Felt reiNforcEmenT of the PancreaticoJejunostomy (PLANET-PJ Trial)
The polyglycolic acid (PGA) felt is a felt-like absorbable suture reinforcing material. The pancreatojejunostomy aimed at reducing POPF is not established at present. We devised a new method using doubly PGA felt.
- Trial name
- NCT03331718
- Testing
- PGA felt reinforcement
- Where
- Japan
- Volunteers
- 514 people
- Sponsor
- University of Toyama
Rectovaginal Fistula, Crohn Disease
Allogenic Stem Cells Derived From Lipoaspirates for the Treatment of Recto-vaginal Fistulas Associated to Crohn's Disease (ALOREVA)
The purpose of this study is to determine safety and efficacy of allogenic eASCs (expanded adult stem cells) for the treatment of recto-vaginal fistula in patients with Crohn´s disease.
- Trial name
- ALOREVA (NCT00999115)
- Testing
- Expanded allogenic adipose-derived adult stem cells
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Fistula in Ano
Role of Udumbara Sutra in the Management of Fistula in Ano a Rare Case Study
The anal fistula is a notorious disease due to its recurrence rate. Bhagandara is varyingly defined as a tear, ulcer or boil at Bhaga (Perianal region) within 2 finger circumference of it, causing painful abscess when opened is…
- Trial name
- Bhagandara (NCT01954225)
- Testing
- Udumbara Sutra
- Where
- India
- Volunteers
- 1 people
- Sponsor
- Government Ayurved College and Hospital