Clinical trials: Digestive System Fistula
Perianal Fistula, Crohn Disease
Autologous Adipose-derived Stem Cells (ASCs) for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study
Crohn's disease is an immunologically mediated inflammatory bowel disease with a reported incidence of 4.0-7.0, 7.1, and 1.34 per 100,000 persons in Europe, the U.S., and Korea, respectively.
- Trial name
- ASPEFIC1 (NCT02403232)
- Testing
- ASCs injection, Closure of fistula tract.
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Papa Giovanni XXIII Hospital
Anal Fistula
BIOlogic Augmented Repair of Complex Anal Fistula Using Acellular Matrix and/or Autologous Platelet-rich Plasma
The purpose of this study is to compare the clinical effectiveness of augmenting surgical repair of complex anal fistula using autologous PRP and/or micronized acellular porcine urinary bladder matrix (UBM) to usual surgical care…
- Trial name
- BIO RAMP (NCT05805449)
- Testing
- Surgery, Platelet-rich plasma (PRP), Matrix
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hemorrhoids, Anal Fistula
Hemostatic and Analgesic Effect of Gel Foam and Gauze With Bosmin After Anal Surgery
To evaluate the hemostatic and analgesic effect of using gauze with Bosmin or Gelfoam after anal surgery.
- Trial name
- NCT05605080
- Testing
- Gelfoam, Bosmin gauze
- Where
- Taiwan
- Volunteers
- 292 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Anal Fistula
Patient's Quality of Life and Functional Changes After Fistula Surgery
This is a prospective observational study that will monitor the effects of surgery for anal fistula on the patient quality of life using many valid questionnaires
- Trial name
- NCT06548724
- Testing
- assessment of quality of life before and after anal surgery
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Fistula in Ano
Study Evaluating the Safety and Efficacy of an ECM Hydrogel for the Treatment of Anorectal Fistulas
Safety and Efficacy of ECMT-100 for the Treatment of Anorectal Fistulas
- Trial name
- NCT07035925
- Testing
- ECMT-100
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- ECM Therapeutics, Inc.
Gastric Cancer, Duodenal Stump Leak
Incidence of Duodenal Stump Fistula After Gastrectomy for Gastric Cancer. A Randomized Controlled Trial
The goal of this trial is to demonstrate that the use of Tri-Staple Technology for duodenal resection during open gastrectomy for cancer is safer than the use of other conventional methods of resection/closure of the duodenum and…
- Trial name
- DRTST (NCT03277144)
- Testing
- TST-TriStaple(3lines stapler)Technology, other conventional techniques
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- University of Turin, Italy
Anal Fistula
Treatment of Complex Anal Fistulas Using Centrifuged Adipose Tissue Containing Progenitor Cells
In the treatment of complex anal fistulas transplant of freshly collected autologous adipose tissue mechanically fragmented or centrifuged adipose tissue (CAT) might be an alternative to in vitro expanded autologous or allogeneic…
- Trial name
- CAT (NCT04326907)
- Testing
- Autologous centrifuged adipose tissue (CAT) injection after anal fistulectomy
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Liver Transplant; Complications, HLA Antigens
The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation
Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates…
- Trial name
- NCT04885582
- Testing
- HLA antigen results
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Vestibular Fistulae
Rectovestibular Fistula Which Surgical Approaches?
This study was a prospective, randomized, comparative study that included female children with rectovestibular fistulae who were selected from patients with anorectal malformations treated at the pediatric surgical unit, Assiut…
- Trial name
- Vestibanus (NCT04970160)
- Testing
- TSARP, PSARP, Classic ASARP
- Volunteers
- 84 people
- Sponsor
- Aswan University Hospital
Gastrointestinal Dysfunction, Hemorrhage
Daytime Variation of Complication in Gastric and Pancreatic Surgery
Evaluate the daytime variation of complications in gastric and pancreatic surgery
- Conditions
- Gastrointestinal Dysfunction, Hemorrhage, Infection, Fistula
- Trial name
- NCT03383562
- Testing
- operation in different stages of the day
- Volunteers
- 200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Anal Fistula
Long-term Follow-up of Anal Fistula Plug
Aim of the study is to evaluate long-term success rate of Biodesign® anal fistula plug for treatment of complex trans-sphincteric anal fistulas.
- Trial name
- NCT03961984
- Testing
- Biodesign® anal fistula plug
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane
High-type Anal Fistulae
Anal Fistula Plug for High-type Anal Fistulae
The aim of this pilot study is to evaluate the efficacy and safety of anal fistula plug in the management of high-type anal fistulae among Hong Kong Chinese patients.
- Trial name
- NCT00487071
- Testing
- Anal fistula plug
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Crohn Disease, Rectal Fistula
A Study Using Artificial Intelligence to Identify Adults With Complex Perianal Fistulas Associated With Crohn's Disease
Natural Language Processing and machine learning are examples of artificial intelligence tools. This study will check if these tools correctly identify people with Crohn's disease with complex perianal fistulas from their medical…
- Trial name
- INTUITION-CPF (NCT04844593)
- Where
- 3 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Takeda
Gall Stone
Colonic Gallstone Ileus, Diagnostic-therapeutic Algorithm
Gallstone ileus is a rare complication of gallstone disease. There is no systematic review on CGI. We analyze published literature on the subject and plan to propose a diagnostic-therapeutic algorithm for CGI.
- Trial name
- NCT04961411
- Testing
- operation or non-operative treatment
- Where
- Croatia
- Volunteers
- 113 people
- Sponsor
- Tomislav Bruketa
Anal Fistula
Anal Fistula and Microdialysis - What is Yet to Learn?
Anal Fistula can be a challenging condition to treat. Microdialysis has never before been used to examine the inner environment of anal fistula. This is now going to be performed.
- Trial name
- NCT04178707
- Testing
- OnZurf Probe, Senzime AB, Uppsala, Sweden
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- University Hospital, Umeå
Healing of the Wound After Rectovaginal Fistula Surgery
the Method of Cotton Padding Promoting the Rectovaginal Fistula Surgery
The method of Cotton Padding (mCP) was summarized by combining with many years clinical experience and the traditional ancient books.The mCP could be used in Rectovaginal Fistula (RVF) post operation effectively,in order to…
- Trial name
- NCT05138965
- Testing
- the mCP with alginates dressing, only alginates dressing
- Where
- 3 sites in China
- Volunteers
- 20 people
- Sponsor
- China Academy of Chinese Medical Sciences
Crohns Disease, Fistula
Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
This study is looking at the advantage of establishing surgical drainage for Crohn's fistulas and abscesses prior to starting medical therapy.
- Conditions
- Crohns Disease, Fistula, Abscess
- Trial name
- NCT01145365
- Testing
- Exam under anesthesia (EUA)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Enterostomy
Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds ("MUC-FIRE" Trial)
The primary objective of this study is to demonstrate that mucous fistula refeeding between enterostomy creation and enterostomy closure reduces the time to full enteral feeds after enterostomy closure compared to standard of…
- Trial name
- MUC-FIRE (NCT03469609)
- Testing
- mucous fistula refeeding
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Fistula in Ano
Compound Phellodendron Decoction May Promote Wound Healing After Anal Fistulotomy
Sitz-bath therapy with Chinese medicine has significant advantages in the management of postoperative wounds of anal fistula. This method not only ensures safety, efficacy, and cost-effectiveness, but also simplifies application.
- Trial name
- CPD (NCT06663527)
- Testing
- Fumigating-washing Therapy With CPD
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Anal Fistula
Adipose Tissue Injection for the Treatment of Complex Cryptoglandular Perianal Fistula
The incidence of complex cryptoglandular anal fistula is high, it affects eminently young patients and implies an important alteration in their quality of life and high prevalence in sick leave.
- Trial name
- AdiTiF (NCT04790123)
- Testing
- Injection of autologous freshly collected adipose tissue
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Mutua de Terrassa