Clinical trials: Digestive System Fistula
Crohn Disease (CD)
Tolerance of Local Administration of Cryopreserved Autologous Stromal Vascular Fraction Combined With Micrograft for the Treatment of Refractory Ano-perineal Fistulas in Crohn's Disease
The ADICROHN-3 study is a prospective, multicenter, open-label cohort study. Its design is supported by the following elements: The results of the ADICROHN pilot study (EudraCT No.
- Trial name
- ADICROHN3 (NCT07629245)
- Testing
- injection of thawed SVF
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Crohn's Disease, Perianal Fistula
MIRICURE: Mirikizumab With Curettage and Repair (Closure) for Perianal Fistulizing Crohn's Disease
This Phase 4, single-arm, open-label study will evaluate the effectiveness and safety of mirikizumab combined with surgical curettage and closure in adults with active perianal fistulizing Crohn's disease.
- Trial name
- MIRICURE (NCT07782021)
- Testing
- Mirikizumab, Fistula Tract Curettage and Closure
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rectal Fistulas
FISTULA-RFA Trial: Radiofrequency Ablation for Perianal Fistula
The goal of this pilot clinical study is to learn whether radiofrequency ablation (RFA) can safely and effectively treat perianal fistulas in adults.
- Trial name
- FISTULA-RFA (NCT07452666)
- Testing
- Radiofrequency Ablation (RFA) for Perianal Fistula
- Volunteers
- 80 people
- Sponsor
- Korea University Ansan Hospital
Pancreatic Fistula
Prospective Trial Evaluating the Effect of Closed Suction Drainage Versus Straight Drainage After Distal Pancreatectomy
A very common complication following distal pancreatectomy is leakage from the pancreas, or what is called a pancreatic fistula.
- Trial name
- NCT02343302
- Testing
- Jackson-Pratt Drain, Non-suctioning drainage
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Anal Fistula
Do Antibiotics Prevent Anal Fistulae Formation?
Purpose: This randomized study assesses the effects of antibiotics on the formation of fistulae after drainage of anorectal abscesses.
- Trial name
- NCT01012843
- Testing
- Amoxicillin-Clavulanate
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Ankara University
Anal Fistula Surgery, Anal Fistula
Impact of Surgical Timing on Anal Fistula Outcomes
This study aims to evaluate if the amount of time a person experiences symptoms of an anal fistula before having surgery affects their surgical outcomes and recovery.
- Conditions
- Anal Fistula Surgery, Anal Fistula, Surgery Timing
- Trial name
- NCT07482241
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pancreatic Cancer, Bile Duct Cancer
Randomized Controlled Trial on Pancreatic Stent Tube in Pancreaticoduodenectomy
The purpose of this study is to determine which stent type is effective in the decrease of postoperative stay and complications across pancreaticojejunostomy after pancreaticoduodenectomy.
- Conditions
- Pancreatic Cancer, Bile Duct Cancer, Ampullary Cancer, Pancreatitis
- Trial name
- NCT00628186
- Testing
- external drainage tube [polyethylene pancreatic drainage tube], internal drainage tube [polyethylene pancreatic drainage tube]
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Wakayama Medical University
Liver Transplantation, Intestinal Perforation
Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital
Liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. However some patients develop intestinal perforations for which the prognosis is poor.
- Conditions
- Liver Transplantation, Intestinal Perforation, Digestive System Fistula, Intestinal Fistula
- Trial name
- Perfogreffe (NCT04180735)
- Testing
- Liver transplantation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Anal Fistula Surgery, Transsphincteric Anal Fistula
Modified LIFT Versus Standard LIFT for Transsphincteric Anal Fistula
This study evaluated two sphincter-preserving surgical techniques for transsphincteric anal fistula: standard ligation of the intersphincteric fistula tract (LIFT) and modified LIFT via a lateral approach.
- Trial name
- NCT07603635
- Testing
- Standard LIFT, Modified LIFT via a Lateral Approach
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tugberk Tok
Pancreatic Fistula, Pancreas Cancer
Preoperative Inflammatory Biomarkers and Postoperative Day 1 Drain Amylase Value Predict Pancreatic Fistula After Pancreaticoduodenectomy
Particularly, pancreatic fistula is the most common and serious complication after pancreaticoduodenectomy (PD) and is reported in up to 40% of cases.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Inflammatory Response
- Trial name
- NCT04361682
- Testing
- Surgical Drain Management
- Volunteers
- 227 people
- Sponsor
- Campus Bio-Medico University
Anorectal Abscess, Fistula in Ano
Feasibility Study to Assess the Early Use of Porcine Cross-linked Collagen Paste in Cryptoglandular Anorectal Fistulas
This study is designed to assess the effectiveness of porcine cross-linked collagen paste for the treatment of patients with ano-rectal abscess with underlying cryptoglandular fistula in ano.
- Trial name
- FIX-IT1 (NCT02686580)
- Testing
- Collagen paste
- Volunteers
- 2 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Esophageal Fistula, Esophageal Neoplasms
Removal of the Evolution® Esophageal Stent - Fully Covered
The CLARITY study is a clinical trial approved by US FDA to study the removal of the Evolution® Esophageal Stent-Fully Covered in malignant and benign indications.
- Conditions
- Esophageal Fistula, Esophageal Neoplasms, Esophageal Perforation, Esophageal Stenosis
- Trial name
- CLARITY (NCT01900691)
- Testing
- Evolution® Esophageal Stent - Fully Covered
- Where
- 11 sites in United States
- Volunteers
- 130 people
- Sponsor
- Cook Group Incorporated
Pancreas; Fistula
Radiofrequency-assisted Transection of the Pancreas vs Stapler
Main objective: The main end-point of this study is to compare in a randomized clinical trial that radiofrequency-assisted pancreas transection (RF) reduces the incidence of postoperative pancreatic fistula (POPF) compared to the…
- Trial name
- TRANSPAIRE (NCT04402346)
- Testing
- Radiofrequency-assisted pancreas transection, Stapler assisted pancreas transection
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Patricia Sanchez Velazquez
Pancreatic Fistula, Pancreas Cancer
Reinforced Pancreaticojejunostomy With or Without glubran2
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend different techniques in pancreatojejunostomy.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Periampullary Carcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06756074
- Testing
- Reinforced pancreaticojejunostomy with tissue adhesive glue modified cyanoacrylate (glubran 2), Pancreaticojejunostomy without tissue adhesive glue modified cyanoacrylate (glubran 2)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Crohn Disease
Self Screening Tool for Crohn's Perianal Fistula
This study aims to develop a self-screening tool for Crohn's perianal fistula.
- Trial name
- NCT03288961
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Kyungpook National University Hospital
Pancreatic Diseases, Pancreatic Neoplasms
POstopeRative Standardization of Care: THe Implementation of Best Practice After Pancreatic Resection
This Nationwide stepped-wedge cluster randomized trial is designed to evaluate if the implementation of a best practice algorithm for postoperative care results in a decrease in incidence of major complications and death after…
- Conditions
- Pancreatic Diseases, Pancreatic Neoplasms, Pancreatic Cancer, Pancreatitis
- Trial name
- PORSCH (NCT03400280)
- Testing
- Best practice algorithm for postoperative care
- Where
- 17 sites in Netherlands
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Pancreatic Fistula, Whipple Operation
Identifing Risk Factors for Pancreaticojejunostomy Leakage Following Pancreaticoduodenectomy
Pancreatic cancer is an aggresive type of cancer with poor mean survival rates despite improvements in chemotherapy regimens and advances in surgical techniques. Surgery is the only therapeutic option with an intend to treat.
- Conditions
- Pancreatic Fistula, Whipple Operation, Pancreaticoduodenectomy, POPF
- Trial name
- NCT04798560
- Testing
- Pancreaticoduodenectomy
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Dimitrios Vouros
Perianal Fistula, Crohn Disease
Surgical Closure vs Anti-TNF in the Treatment of Perianal Fistulas in Crohn's Disease (PISA-II): a Comprehensive Cohort Design
Currently, the treatment of Crohn's patients with perianal fistulas predominantly exists of anti-TNF medication. However, its efficiency has never been directly compared to surgical closure of the perianal fistula.
- Trial name
- PISA-II (NCT06441526)
- Testing
- anti-tumour necrosis factor α antibodies, Advancement plasty
- Where
- Netherlands
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rectovaginal Fistula
Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula
A new strategy for treatment of late radiation damage is to develop methods aimed at stimulating the regenerative capabilities of irradiated tissues.
- Trial name
- NCT03643614
- Testing
- Injection of autologous regenerative cells of adipose tissue
- Where
- Russia
- Volunteers
- 16 people
- Sponsor
- South Ural State Medical University