Clinical trials: Digestive Tract Diseases
Autism Spectrum Disorder
Exploring the Gut-Brain-Behavior Axis With Biomarkers, Probiotic Efficacy, and Artificial Intelligence Algorithms
With an increased prevalence of autism spectrum disorder (ASD) worldwide and in Taiwan, ASD demands urgent attention due to its lasting impact, unclear causes, and limited diagnostic and treatment options.
- Trial name
- NCT06677840
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- National Taiwan University Hospital
Atopic Eczema
A Pilot Study of Efficacy and Safety of SIM05 in Adults With Atopic Eczema
Atopic eczema causes significant disease burdens worldwide. Some studies reported gastrointestinal symptoms in eczema patients which could be related to gut microbiota change.
- Trial name
- NCT06230991
- Testing
- SIM05
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Obesity
Effect of Diet Versus Sleeve Gastrectomy and Gastric Bypass on Appetite
The biggest challenge in obesity management is maintaining weight loss in the long-term. Currently, bariatric surgery is the most effective treatment, leading to sustained weight loss that is not yet achievable with lifestyle…
- Trial name
- DISGAP (NCT04051190)
- Testing
- VLED group, Sleeve Gastrectomy group, Gastric Bypass group
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Irritable Bowel Syndrome (IBS)
IBS-Oriented CDED Versus Low FODMAP Diet for Irritable Bowel Syndrome
Background: Irritable Bowel Syndrome (IBS) affects approximately 4.1% of the global population and imposes a significant personal and healthcare burden.
- Trial name
- IBS-CDED (NCT07707635)
- Testing
- Modified Crohn's Disease Exclusion Diet (CDED), Low FODMAP Diet
- Volunteers
- 150 people
- Sponsor
- Ariel University
Cholecystolithiasis
SILS Cholecystectomy: Cholangiography of the Biliary Tract
Single Incision Laparoscopic Surgery (SILS) can be performed for different standard operations such as appendectomy and cholecystectomy.
- Trial name
- NCT01056250
- Testing
- SILS cholangiography
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- St John of God Hospital, Vienna
Obesity, Diabetes
Calcium-protein Co-ingestion and Gut Hormones
Gut hormones have therapeutic potential in the prevention and treatment obesity and type 2 diabetes (T2D). Rodent evidence suggests that calcium may potentiate the effects of protein ingestion on gut hormone secretion.
- Trial name
- NCT03370497
- Testing
- Milk Mineral Supplement, Whey Protein Hydrolysate
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Bath
Cystic Fibrosis
A Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-CFTR Mutation
Study to evaluate the efficacy of VX-661 in combination with ivacaftor (IVA, VX-770) through Week 12 in participants with cystic fibrosis (CF) who are heterozygous for the F508del mutation on the CF transmembrane conductance…
- Trial name
- NCT02516410
- Testing
- VX-661 plus ivacaftor combination, Ivacaftor
- Where
- 41 sites in United States, Australia and 5 more
- Volunteers
- 168 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Primary Biliary Cholangitis
EXerCise Intervention in cholesTatic LivEr Disease: The EXCITED Study
A prospective, single centre, single-arm, pilot study investigating the safety and efficacy of a 12-week remotely-monitored home-based exercise program in patients with refractory fatigue (based on PBC-40 Quality of Life measure)…
- Trial name
- EXCITED (NCT04265235)
- Testing
- Home-based exercise program
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Birmingham
Ovarian Cancer, Pancreas Cancer
Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma
Study QXL138AM-001 is a Phase 1a/1b study to investigate the safety, pharmacokinetics, and preliminary activity of QXL138AM in subjects with locally advanced un-resectable and/or metastatic solid tumors and multiple myeloma.
- Conditions
- Ovarian Cancer, Pancreas Cancer, Urothelial Carcinoma, Renal Cell Carcinoma
- Trial name
- NCT06582017
- Testing
- QXL138AM Injection every 2 weeks by IV Infusion
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- Nammi Therapeutics Inc
Hiv, Atherosclerosis
Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in…
- Conditions
- Hiv, Atherosclerosis, Diet, Healthy
- Trial name
- NCT06560840
- Testing
- dietary intervention
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Fudan University
Stomach Neoplasm, Intestinal Neoplasm
Multicentric Study an Endoscopic Treatment of Digestive Neoplasia by Submucosal Dissection Evaluation of a New Water Jet System
safety evaluation of endoscopic sub-mucosal dissection with nestis enki2 system. This system is a new water jet system which allows to perform Endoscopic submucosal dissection with a bifunctional catheter (injection and cutting).
- Conditions
- Stomach Neoplasm, Intestinal Neoplasm, Rectal Neoplasm
- Trial name
- NCT01910974
- Testing
- endoscopic sub-mucosal dissection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hôpital Edouard Herriot
The Incidence of Gall Stones After Bariatric Surgery and Its Association With Weight Loss
The Incidence of Gall Stones After Bariatric Surgery and Its Association With Weight Loss
The incidence of Gall Stones after Bariatric surgery and its association with weight loss
- Trial name
- NCT04765618
- Testing
- bariatric surgery
- Where
- Egypt
- Volunteers
- 148 people
- Sponsor
- Helwan University
Gastric Cancer, COVID-19 Pandemic
The Impact of COVID-19 Pandemic on Clinical Presentation and Staging of Gastric Cancer
This was a retrospective case-control study designed and conducted under the approval of the ethic committee of Tehran University of Medical Sciences.
- Conditions
- Gastric Cancer, COVID-19 Pandemic, Peritoneal Metastases
- Trial name
- NCT05130710
- Testing
- staging laparoscopy
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Gallbladder Volvulus
Gallbladder Volvulus Diagnosed Intraoperatively: Case Report
85-year-old female patient presented with right upper quadrant pain of one day duration, diagnosed with acalculous cholecystitis, and intraoperatively diagnosed with gallbladder volvulus.
- Trial name
- NCT06050876
- Testing
- Laparoscopic cholecystectomy for gallbladder volvulus
- Where
- Lebanon
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Balamand
Breast Cancer, Lung Cancer
Nausea or Vomiting in Patients Who Are Receiving Chemotherapy for Breast Cancer or Lung Cancer
RATIONALE: Understanding how nausea or vomiting caused by chemotherapy effects a patient's treatment decisions may help doctors plan better cancer treatment and may help patients live more comfortably.
- Conditions
- Breast Cancer, Lung Cancer, Nausea and Vomiting
- Trial name
- NCT00416689
- Testing
- assessment of therapy complications, quality-of-life assessment
- Volunteers
- 99 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cystic Fibrosis
Detection of Pseudomonas Aeruginosa in the Airways of Patients With CF
The purpose of this study is to determine if inhaled urea can be used to detect the presence of Pseudomonas Aeruginosa in the lungs
- Trial name
- NCT01303068
- Testing
- 13C urea breath test Kit
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Digestive Disease, Gut Health
Impact of B. Adolescentis iVS-1 Probiotic on Gastrointestinal Outcomes
The study team is conducting a consumer-driven, decentralized clinical research study to assess the impact of the consumer-grade probiotic supplement, iVS-1, on adults with moderate to severe gastrointestinal discomfort.
- Trial name
- NCT07408518
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Synbiotic Health
Abdominal Pain, Acute Pain
Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions
The goal of this non-inferiority observational study is to assess the diagnostic performance of low-dose CT with deep learning image reconstruction (DLIR) in adult participants with acute abdominal conditions.
- Conditions
- Abdominal Pain, Acute Pain, Acute Cholecystitis, Acute Appendicitis
- Trial name
- DETECT_Acute (NCT05651360)
- Testing
- low-dose CT
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 246 people
- Sponsor
- Oslo University Hospital
Rectal Neoplasms, Sexual Dysfunction
Robotic Versus Laparoscopic Low Anterior Resection for Rectal Cancer
Prospective randomized trial comparing robotic versus laparoscopic Low anterior resection for rectal cancer. Primary endpoint: Compare urinary dysfunction between robotic and laparoscopic approach.
- Conditions
- Rectal Neoplasms, Sexual Dysfunction, Urinary Incontinence, Quality of Life
- Trial name
- RAR (NCT03209076)
- Testing
- Robotic, Laparoscopic
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Cholangiocarcinoma, Gall Bladder Carcinoma
Durvalumab and Tremelimumab With Gemcitabine or Gemcitabine/Cisplatin Compared to Gemcitabine/Cisplatin in CCA Patients
To determine the efficacy in terms of objective response rate (ORR) of the combination of durvalumab and tremelimumab in addition with gemcitabine or in addition with gemcitabine and cisplatin in treatment-naïve patients with…
- Conditions
- Cholangiocarcinoma, Gall Bladder Carcinoma, Cholangiocarcinoma Non-resectable, Gallbladder Carcinoma Non-Resectable
- Trial name
- IMMUCHEC (NCT03473574)
- Testing
- Durvalumab, Gemcitabine, Cisplatin
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- AIO-Studien-gGmbH
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