Clinical trials: Dilated Cardiomyopathies
Cardiomyopathies, Dilated Cardiomyopathy
Pediatric Cardiomyopathy Mutation Analysis
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder.
- Conditions
- Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT02432092
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Dilated Cardiomyopathy, Lef Ventricular Dysfunction
Prospective Becker-Heart-Study
The purpose of this study is to determine whether electrocardiogram, echocardiography, cardiac MRI, sera biomarkers can improve early detection of myocardial involvement and clinical outcome.
- Conditions
- Dilated Cardiomyopathy, Lef Ventricular Dysfunction, Heart Failure
- Trial name
- Becker-HS (NCT02020954)
- Testing
- ECG, echocardiography, cardiac MRI, sera biomarkers
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Karim WAHBI
Dilated Cardiomyopathy
Effect of Rosuvastatin on Left Ventricular Remodeling
The purpose of this study is to examine the the effect of the HMG-CoA reductase inhibitor Rosuvastatin on left ventricular remodeling in patients with dilated cardiomyopathy.
- Trial name
- NCT00505154
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Oslo University Hospital
Cardiovascular Diseases, Heart Diseases
Epidemiology of Idiopathic Dilated Cardiomyopathy (Washington, DC Dilated Cardiomyopathy Study)
To identify risk factors for idiopathic dilated cardiomyopathy and to examine prognostic factors over a follow-up period of two to three years.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Diseases, Asthma
- Trial name
- NCT00005262
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Dilated Cardiomyopathy (DCM)
The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study
Dilated cardiomyopathy (DCM) affects about 200,000 Canadians. Eighty percent of these cases are of unclear cause, often occuring in families.
- Trial name
- NCT00523653
- Testing
- blood test
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Non-ischemic Dilated Cardiomyopathy
Administration of Allogeneic-MSC in Patients With Non-Ischemic Dilated Cardiomyopathy
The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called human allogeneic mesenchymal stem cell therapy.
- Trial name
- DCMII (NCT04476901)
- Testing
- allogeneic human mesenchymal stem cells (hMSCs)
- Where
- 4 sites in United States
- Volunteers
- 107 people
- Sponsor
- Joshua M Hare
Cardiomyopathies
Combined Spinal- Epidural Anesthesia in Patients With Dilated Cardiomyopathy
This study was conducted on 24 patients who have ischemic dilated cardiomyopathy, underwent non cardiac surgery in the lower half of the body under the effect of combined spinal epidural anesthesia at Assiut university hospital.
- Trial name
- NCT03051529
- Testing
- combined spinal epidural anesthesia
- Volunteers
- 24 people
- Sponsor
- Assiut University
DMD-Associated Dilated Cardiomyopathy
TXA127 in Non-Ambulant Patients With DMD Cardiomyopathy
This open-label, single-arm multi-center study studying the safety and efficacy of TXA127 on non-ambulant patients with DMD Cardiomyopathy will comprise of two phases: 1.
- Trial name
- NCT06013839
- Testing
- talfirastide
- Where
- 2 sites in Israel
- Volunteers
- 10 people
- Sponsor
- Constant Therapeutics LLC
Cardiomyopathy, Dilated
Immunoadsorption Therapy for Patients With Non-Ischemic Dilated Cardiomyopathy (DCM)
The purpose of this study is to evaluate the clinical safety and feasibility of Mysorba in patients with chronic non-ischemic dilated cardiomyopathy (DCM).
- Trial name
- NCT01478087
- Testing
- Mysorba
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Asahi Kasei Medical Co., Ltd.
Cardiomyopathies
Genetic Characterization of Cardiomyopathies (POLICARDIOMIO2021)
Cardiomyopathy refers to a diverse group of myocardial diseases with multiple causes. In 1995, the World Health Organization classified cardiomyopathies into hypertrophic, dilated, restrictive, and mixed type.
- Trial name
- NCT05556369
- Where
- Italy
- Volunteers
- 288 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Myocardial Infarction, Dilated Cardiomyopathy
Arrhythmia Prediction Trial
Patients with Ischaemic and Dilated Cardiomyopathy, face an increased risk for Arrhythmic Sudden Cardiac Death. The purpose of this study is to estimate the performance of Modern Non-Invasive Indices and the performance of…
- Conditions
- Myocardial Infarction, Dilated Cardiomyopathy, Heart Failure
- Trial name
- APRET (NCT02175836)
- Where
- Greece
- Volunteers
- 500 people
- Sponsor
- University of Athens
Cardiomyopathy
Acute Dietary Nitrate in Dilated Cardiomyopathy
Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD.
- Trial name
- NCT02471417
- Testing
- Dietary nitrate
- Volunteers
- 12 people
- Sponsor
- Royal College of Surgeons, Ireland
Zinc Deficiency
Zinc Deficiency in Dilated Cardiomyopathy
The aim of this study is to detect effect of oral zinc supplementation in pediatric patients with dilated cardiomyopathy.
- Trial name
- NCT04860921
- Volunteers
- 50 people
- Sponsor
- Assiut University
Congestive Heart Failure
Effects of HTEA ON Heart Failure Secondary to Idiopathic Dilated Cardiomyopathy or Post-myocardial Infarction
The investigators would evaluate the effects of the novel method, HTEA on cardiac function in the heart failure patients secondary to idiopathic dilated cardiomyopathy and post-myocardial infarction.
- Trial name
- NCT02292043
- Testing
- HTEA
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Harbin Medical University
Dilated Cardiomyopathy
Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM)
This study is designed to assess the safety and tolerability of Cardiac Repair Cells (CRCs) compared to standard-of-care in patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT00765518
- Testing
- Ixmyelocel-T, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vericel Corporation
Cardiomyopathy
AI-SCREENDCM Decentralized Clinical Trial - Pilot Study
The purpose of this study is to assess the feasibility and impact of screening FDR of DCM probands using a mobile ECG with the ability to transmit the ECG for cloud-based AI analysis to detect reduced left ventricular ejection…
- Trial name
- NCT06609174
- Testing
- KardiaRx ECG Screening and AI interpretation of ECG
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Mayo Clinic
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Ischemic Heart Disease
By Pass Surgery With Stem Cell Therapy in Chronic Ischemic Cardiopathy
Surgical revascularization has proven its efficacy in term of morbidity and mortality in patients with multivessel coronary disease and poor left ventricular function.
- Trial name
- NCT00690209
- Testing
- Autologous bone marrow derived stem cells myocardial transplantation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiomyopathy, Dilated
Prognostic Value of Myocardial Fibrosis Quantified Using CMR in Patient With Dilated Cardiomyopathy
: Fibrosis, in general, is a scarring process, which is characterized by fibroblast accumulation and excess deposition of extracellular matrix (ECM) proteins, which leads to distorted organ architecture and function.
- Trial name
- NCT02352129
- Testing
- CMR using T1 mapping technique
- Where
- France
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille