Clinical trials: Disabilities, Intellectual
Autism, Fragile-X Syndrome (FXS)
Glutaminergic Transmission in Autism : Molecular Imaging Exploration
Glutamatergic transmission exploration using PET (Positron Emission Tomography) imaging in autism compared to Fragile-X Syndrome ( FXS) and Healthy Volunteers
- Conditions
- Autism, Fragile-X Syndrome (FXS), Healthy Volunteers
- Trial name
- TANGAU (NCT02719951)
- Testing
- [18F]FPEB PET imaging, Biological samples, MRI
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Down Syndrome, Alzheimer's Disease
Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome
The purpose of this study is to develop small molecule radio-labeled probes of beta-amyloid, to be used with positron emission tomography (PET) for early detection and treatment monitoring of Alzheimer disease (AD).
- Trial name
- NCT00965835
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Down Syndrome, Amyloid Beta-protein
Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid.
To determine the sensitivity of the visual assessment of BAY94-9172 PET images in detecting cerebral β-amyloid in individuals with Down Syndrome (DS) and specificity in individuals without DS.
- Trial name
- NCT00928304
- Testing
- Florbetaben (BAY94-9172)
- Where
- 2 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Lantheus Biosciences Ltd.
Down Syndrome
Effect of Sensory Integration on Gross and Balance on Children With Down Syndrome
To investigate the effect of sensory integration on gross motor function in children with Down syndrome. To investigate the effect of sensory integration on balance in children with Down syndrome.
- Trial name
- NCT07785011
- Testing
- BALANCE AND SENSORY INTEGRATION
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Raheel Sanad
Down Syndrome, Down Syndrome, Partial Trisomy 21
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Progressive age-related cognitive deficits occurring in both AD and DS have been connected to the degeneration of several neuronal populations, but mechanisms are not fully elucidated.
- Conditions
- Down Syndrome, Down Syndrome, Partial Trisomy 21, Alzheimer Disease
- Trial name
- NCT05231798
- Testing
- [18F]-FEOBV Radiotracer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Intellectual Disability
Safer Online Lives: Use of the Internet & Social Media by People With Intellectual Disabilities
The objective of this study is to explore the benefits of internet use for people with intellectual disabilities (ID), the risks they might come up against while online, the barriers people with ID might come across due to the…
- Trial name
- SOL (NCT04919213)
- Where
- United Kingdom
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- University of Kent
Health-Related Behavior, Quality of Life
PODER Familiar: Health Promotion for Latino Families of Children With IDD
The goal of this clinical trial is to test a culturally tailored health promotion intervention for children with IDD and their families.
- Conditions
- Health-Related Behavior, Quality of Life, Psychological Distress, Diet, Healthy
- Trial name
- PODER (NCT05713617)
- Testing
- PODER Familiar
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Prader Willi Syndrome, Hyperphagia
Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact
The goal of this observational study is to explore brain network changes and identify patterns related to hyperphagia, hormonal treatment effects, and cognitive deficits in adults with Prader-Willi Syndrome (PWS).
- Conditions
- Prader Willi Syndrome, Hyperphagia, Behavior Disorders
- Trial name
- NCT06900335
- Testing
- GH treatment (Somatropin), Eating
- Where
- Spain
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Intellectual Developmental Disorder
Emotional Processes in Adults With Intellectual Developmental Disorder
Emotions play a crucial part in the quality of life, interpersonal relationships and mental health in general. In adults presenting with intellectual developmental disorder (IDD), emotional abilities may be hindered, thus leading…
- Trial name
- EmoTDI (NCT07303270)
- Testing
- ACQUISS protocol assessing emotional processing.
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Intellectual Disability, Speech and Language Disorder
Early Augmentative and Alternative Communication (AAC) Intervention Delivered Via Hybrid Telehealth
The goal of this mixed methods study aims to develop and pilot test an augmentative and alternative communication (AAC) intervention for toddlers with intellectual and developmental disabilities (IDD) and their families.
- Trial name
- NCT05743439
- Testing
- Early Augmentative and Alternative Communication (AAC) Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pregnancy
Assessment of Women's Insight and Understanding of Down's Syndrome Screening by Non-invasive Prenatal Testing (NIPT) During Their First Ultrasound
Down's syndrome is the leading cause for mental retardation in France. Screening for this chromosomal abnormality is systematically proposed during pregnancy.
- Trial name
- DEPIST21 (NCT03549286)
- Testing
- Questionnaire passation
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Quality of Life
Effects of the MBHP on the Quality of Life of Family Members of People With Intellectual Disability
The research aims to verify the effects of the Mindfulness Based Health Promotion (PSBM) program on the quality of life of mothers of person with intellectual disability.
- Trial name
- caregivers (NCT03756441)
- Testing
- Mindfulness meditation, Psychotherapy group
- Where
- Brazil
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Centro Mente Aberta de Mindfulness
Prader Willi Syndrome, Obesity
Characterization of Transcriptional Regulators of Ghrelin Hormone Which Causes Genetic Obesity
The problem point of the Prader-Willi Syndrome (PWS) patient is the obesity which is intense and the plasma ghrelin level which increases unusual from the recently PWS patients was discovered.
- Trial name
- NCT01404624
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Posture, Balance
Training Balance Among People With Neurodevelopmental Disabilities
This study is a case control pilot study to investigate the impact of a short-term intervention on training anticipatory postural adjustments in a population of people with neurodevelopmental disabilities.
- Conditions
- Posture, Balance, Cerebral Palsy, Autism
- Trial name
- TAPAS (NCT04293120)
- Testing
- Training with weighted ball
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Hartford
Obstructive Sleep Apnea, Down Syndrome
Validation of Sleep Questionnaires in the Down Syndrome Population
This will be a prospective validation study of a sample of consecutive pediatric Down syndrome patients who are seen through the weekly Down syndrome clinic at OHSU/Doernbecher's.
- Trial name
- NCT03771469
- Testing
- Sleep study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Down Syndrome
Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS)
Purpose: To assess the feasibility of using videos depicting people with DS to teach other adults with DS to perform healthy behaviors.
- Trial name
- NCT02895802
- Testing
- Verbal instructions with picture diagram, Verbal instructions with video of ADSC, verbal instructions w. video of w/o DS
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Down Syndrome
Digital Dysmorphology Project
In this study, the investigators propose a novel method to detect Down syndrome using photography for facial dysmorphology, a tool called computer-aided diagnosis (CAD).
- Trial name
- NCT02651493
- Testing
- photographs
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Kevin Cleary
Alzheimer's Disease, Dementia
Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical…
- Conditions
- Alzheimer's Disease, Dementia, Down's Syndrome
- Trial name
- NCT00001178
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Trisomy 21
Down Syndrome Screening Based on Dried Blood Spots and Cell-free Fetal DNA
There are 26,600 Down Syndrome newborns every year in China. The economic burden of this disease is 65,000 USD for lifetime of every patient.
- Trial name
- DBS&CFF (NCT01837979)
- Testing
- cell-free fetal DNA
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital