Clinical trials: Disabilities, open to volunteers
Mobility Disability
Wearable Robotics to Overcome Exercise Dose Limitations in Older Adults - Study 2
The purpose of this research is to learn whether a lightweight wearable robotic device called We Innovate Mobility (WIM) can improve exercise capacity and physical function for older adults.
- Trial name
- NCT07859605
- Testing
- We Innovate Mobility (WIM) Device, Conventional Treadmill Walking
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Stroke, Dementia
Taiwan Post-Stroke Disability Study
Stroke remains a major health issue in Taiwan, being the fourth leading cause of death and the top cause of disability. While past research has focused on functional outcomes at three months post-stroke, stroke can cause a range…
- Conditions
- Stroke, Dementia, Epilepsy, Depression
- Trial name
- T-PODS (NCT06772194)
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- National Taiwan University Hospital
Down Syndrome, Down Syndrome, Partial Trisomy 21
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Progressive age-related cognitive deficits occurring in both AD and DS have been connected to the degeneration of several neuronal populations, but mechanisms are not fully elucidated.
- Conditions
- Down Syndrome, Down Syndrome, Partial Trisomy 21, Alzheimer Disease
- Trial name
- NCT05231798
- Testing
- [18F]-FEOBV Radiotracer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Menkes Disease
NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease
This clinical trial will evaluate the safety, tolerability, dosing, and efficacy of Northera (Droxidopa) in children with Menkes disease aged 7 to 17 years who survived the major neurodegenerative and neurocognitive effects of…
- Trial name
- NCT07398508
- Testing
- Droxidopa Oral Product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stephen G. Kaler
Shoulder Pain, Sleep Quality
Effects of Respiratory Muscle Strengthening and Diaphragmatic Breathing on Shoulder Pain and Disability
The aim of the study is to investigate the effects of respiratory muscle strengthening and diaphragmatic breathing on pain levels, respiratory capacity and sleep quality in participants with shoulder pain and disability.
- Conditions
- Shoulder Pain, Sleep Quality, Lung Cavity, Pain Intensity
- Trial name
- NCT07885215
- Testing
- shoulder rehabilitation, respiratory muscle strengthening exercises and diaphragmatic breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Zonguldak Bulent Ecevit University
Chronic Non-Specific Low Back Pain, Myofascial Release
Effects of 3-dimensional Versus Dynamic Myofascial Release Techniques With Lumbar Mobilization and Exercise Therapy Program in Chronic Non-specific Low Back Pain.
Ninety percent of cases of LBP are nonspecific, which means they do not have an obvious reason like an infection or tumor. Pain that spreads from the thoracic spine to the gluteal area and upper leg is a common sign.
- Trial name
- NCT07920991
- Testing
- 3 Dimensional Myofascial Release, Dynamic Myofascial Release, Lumbar Mobilization
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
Child, Only, Disabilities Multiple
Pediatric Medication Therapy Management Trial
The purpose of this study is to evaluate whether an intervention called Pediatric Medication Therapy Management (pMTM) improves the identification and management of medication-related problems among children with medical…
- Conditions
- Child, Only, Disabilities Multiple, Medication Interaction, Medication Compliance
- Trial name
- pMTM (NCT05761847)
- Testing
- Pediatric Medication Therapy Management (pMTM)
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- University of Colorado, Denver
Supraspinatus Tendinopathy, Type 2 Diabetes Mellitus (T2DM)
Effects of Aerobic Exercise on Shoulder Pain, Disability, and Ultrasonographic Outcomes in Patients With Type 2 Diabetes Mellitus With Supraspinatus Tendinopathy
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by elevated blood glucose levels over a prolonged period. If left untreated, it can lead to serious and long-term vascular and neurological complications.
- Trial name
- NCT07784543
- Testing
- Conventional Shoulder Rehabilitation, Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Pamukkale University
Mobility Disability
Cocoa to Maximize Exercise Training in Older Adults - The COMET Trial
The purpose of the study is to see if regular exercise when combined with a cocoa supplement will improve physical performance and muscle strength compared to regular exercise alone.
- Trial name
- COMET (NCT07161726)
- Testing
- (-)-Epicatechin-rich cocoa supplementation combined with exercise training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Cancer Awareness and Prevention Education, Breast Cancer Awareness
A Single-Arm Interventional Trial of Pepper- Robot Delivered Cancer Education for Adults With Intellectual Disability
Individuals with Intellectual disability face numerous barriers to cancer education, awareness and screening, including communication challenges, anxiety, and a lack of accessible educational resources.
- Conditions
- Cancer Awareness and Prevention Education, Breast Cancer Awareness, Intellectual Disabilities (F70-F79)
- Trial name
- Pep-SMARTID (NCT07477938)
- Testing
- Robot delivered Education
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- National University of Ireland, Galway, Ireland
Sports Physical Therapy
Comparative Effects of Spencer Muscle Energy Technique Versus Post Facilitation Stretch Among Fast Bowlers
This study compares the effectiveness of Spencer Muscle Energy Technique and Post Facilitation Stretch in reducing shoulder pain in 32 fast bowlers aged 18-35.
- Trial name
- NCT07062926
- Testing
- Spencer Muscle Energy Technique, Post Facilitation Stretch
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Lumbar Spinal Stenosis, Numerical Rating Scale
Presence of Dural Pulsation in Patients Diagnosed With Lumbar Spinal Stenosis
Lumbar spinal stenosis is defined as the narrowing of the spinal canal resulting from degenerative changes in the spinal joints, intervertebral discs, and the ligamentum flavum.
- Conditions
- Lumbar Spinal Stenosis, Numerical Rating Scale, Disability Physical, Magnetic Resonance
- Trial name
- NCT07233798
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Chronic Migraine
Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine
The goal of this clinical trial is to learn if the behavioral treatment called Acceptance and Commitment Therapy (ACT) works to improve disability in adults with chronic migraine.
- Trial name
- NCT06795867
- Testing
- acceptance and commitment therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Cerebral Palsy
Effects of Associated Impairments on Activity and Participation in Children With Cerebral Palsy
This study will investigate the effects of associated impairments on the activity levels and social participation of school-aged children with Cerebral Palsy (aged 6-12) and their impact on their families' quality of life and…
- Trial name
- NCT06944171
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Hacettepe University
X-linked Adrenoleukodystrophy
Validation of a Prognostic Biomarker Using Brain Diffusion MRI in X-linked Adrenoleukodystrophy
CALD is an inflammatory demyelinating disease that causes severe motor and cognitive deficit leading to rapid death. Hematopoietic stem cell transplantation (HSCT) can halt neuroinflammation in CALD through the replacement of…
- Trial name
- CALDIFF (NCT05911919)
- Testing
- brainQuant module of brainTale-care platform
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hearing Disability, Depression
Reduction of Depression Through Dual Treatment: Digital CBT & NBHWC Coaching
The purpose of this study is to see if a mobile-delivered mental health program called Toivoa-002, which combines digital cognitive behavioral therapy (CBT) with personal coaching, can effectively reduce depression in adults with…
- Conditions
- Hearing Disability, Depression, Mobility Disability
- Trial name
- NCT07195292
- Testing
- Toivoa-002 - A digital Cognitive Behavioral Therapy program combined with NBHWC-certified coaching.
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Toivoa Inc
Headache (Migraine)
Prevalence and Determinants of Migraine Among Headache Patients
Migraine is a prevalent and disabling neurological condition that often coexists with other health issues, such as hypertension and impaired physical, mental, and social functioning.
- Trial name
- NCT07038499
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Universiti Tunku Abdul Rahman
Down Syndrome (DS)
Suspension Therapy Effects on Mobility and Balance in Down Syndrome
Down syndrome (DS) is one of the most common congenital disorders. Individuals with Down syndrome present with several impairments such as hypotonia, ligament laxity, decreased muscle strength, insufficient muscular…
- Trial name
- STOMP (NCT06748248)
- Testing
- suspension Therapy, Routine Treatment
- Where
- 2 sites in Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Cerebral Palsy, Pediatric Stroke
BCI@Home: Brain Computer Interface Solutions to Enable Youth Living With Severe Disabilities
The goal of this trial is to evaluate use of brain computer interfaces (BCI) at home for children with severe severe physical disabilities. The main questions it aims to answer are: 1.
- Conditions
- Cerebral Palsy, Pediatric Stroke, Genetic Condition, Acquired Brain Injury (Including Stroke)
- Trial name
- BCI@home (NCT07073378)
- Testing
- Brain computer interface
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Elbow Stiffness, Elbow Pain
Comparative Effects of Mulligan Mobilization With and Without Myofascial Release Technique in Management of Post Traumatic Elbow Stiffness
The Randomize Clinical Trial will involve 30 participants with post traumatic elbow stiffness recruited from Madinah Teaching Hospital and Chiniot General hospital Faisalabad. Consecutive sampling technique will be used.
- Trial name
- NCT07598526
- Testing
- Group A (Mulligan Mobilization with Myofascial Release Technique), Group B (Mulligan Mobilization alone)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Faisalabad