Clinical trials: Disability, Evaluation
MPS II, Hunter Syndrome (MPS II)
RGX-121-3102 Gene Therapy in Participants With MPS II (Hunter Syndrome)
RGX-121 is a gene therapy which is intended to deliver a functional copy of the iduronate-2-sulfatase gene (IDS) to the central nervous system.
- Trial name
- NCT07236606
- Testing
- RGX-121-3102
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- REGENXBIO Inc.
Mucopolysaccharidosis (MPS), Hunter Syndrome
Observational Study to Evaluate Neurodevelopmental Status in Pediatric Patients With Hunter Syndrome (MPS II)
Hunter syndrome (Mucopolysaccharidosis II, [MPS II]) is a rare, genetically linked lysosomal storage disease (LSD) caused by deficiency of the enzyme, iduronate-2-sulfatase (I2S).
- Trial name
- NCT01822184
- Where
- 7 sites in United States, Argentina and 3 more
- Volunteers
- 100 people
- Sponsor
- Shire
Autism, Developmental Delay Disorders
Project EARLY: Engagement, Assessment, Referral, & Linkage for Young Children
Emerging evidence demonstrates that Autism Spectrum Disorder (ASD) can be reliably diagnosed by age two, and that early identification and intervention can improve outcomes.
- Trial name
- NCT02359084
- Testing
- Family Navigation, Conventional Care Management
- Where
- 10 sites in United States
- Volunteers
- 340 people
- Sponsor
- Boston University
Concussion, Mild, Post Concussion Symptoms
RTL Concussion Communication
This study is aimed at improving health outcomes for adolescents who sustain sport and recreation related concussions (SRRC) by enhancing Return to Learn (RTL).
- Conditions
- Concussion, Mild, Post Concussion Symptoms, Cognitive Impairments, Cognitive Impairments, Mild
- Trial name
- NCT06212726
- Testing
- InjureFree
- Sponsor
- University of Florida
Fragile X Syndrome (FXS), Fragile X Syndrome
Safety, Tolerability, and Preliminary Effectiveness of CTH120 in Fragile X Syndrome
The purpose of this Phase IIa study is to evaluate the safety, tolerability, and effectiveness of CTH120 in adult males with Fragile X syndrome.
- Trial name
- FXS-CTH120-01 (NCT07654114)
- Testing
- CTH120
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Connecta Therapeutics, S.L.
Chronotype, Fibromyalgia Syndrome
Evaluation of Chronotype and Central Sensitization in Patients With Fibromyalgia Syndrome
The aim of study is to examine the chronotype preferences of patients with fibromyalgia syndrome and the relationship between central sensitization and chronotype, and to examine its relationship with pain intensity, disability…
- Trial name
- NCT06197087
- Testing
- cross-sectional observational survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Oğuzhan Kandemir
Coxofemoral Pathologies
Transcultural and Psychometric Validation of SUSHI and HOOS-12 Scores in Patients With Coxofemoral Pathologies
The management of coxofemoral pathologies is constantly increasing. In addition to degenerative hip pathology, the orthopedic surgeon is now confronted with pathologies such as femoro-acetabular conflict, pathologies of the…
- Trial name
- HIP (NCT04470232)
- Testing
- Self-assessment questionnaires
- Where
- 3 sites in France, Martinique
- Volunteers
- 120 people
- Sponsor
- University Hospital Center of Martinique
Migraine
Validity and Reliability of the Greek Pain Catastrophizing Scale
Migraine is a common neurological disorder that can significantly affect daily activities, quality of life, and emotional well-being. How individuals think and feel about pain may also influence their experience of migraine.
- Trial name
- NCT07847528
- Where
- Greece
- Volunteers
- 130 people
- Sponsor
- National and Kapodistrian University of Athens
Dyslexia
Evaluation of the Performance and Safety of a Medical Device Developed to Improve the Reading of Dyslexic Patients
The aim of this study is to evaluate the efficacy and safety of a new medical device on the improvement of reading skills of dyslexic patients.
- Trial name
- DysLight (NCT04157829)
- Testing
- Scintilling lamp, Classic lamp
- Where
- 4 sites in France
- Volunteers
- 33 people
- Sponsor
- SATT Ouest Valorisation
Aneuploidy, Trisomy 21
Non-Invasive Chromosomal Evaluation of Trisomy Study
This study is being conducted to provide clinically annotated samples to support continued improvements in the Ariosa Test content, methodology, specimen processing and quality control.
- Conditions
- Aneuploidy, Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- NICHE (NCT02201862)
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Cindy Cisneros
Dementia
Cross-cultural Adaptation of the Greek Version of Disability Assessment for Dementia
The main purpose of this study is primarily the translation and cross-cultural adaptation into Greek and then the investigation of validity and reliability in the Greek target population.
- Trial name
- DAD-Gr (NCT05850715)
- Testing
- Disability Assessment for Dementia (DAD)
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Spasticity
Vanderbilt University Spasticity Management Program Evaluation Plan
People with severe developmental disabilities frequently have comorbidities that make providing care to them more difficult. Spasticity is one such comorbidity.
- Trial name
- NCT00179114
- Testing
- Botulinum Toxin Type A, Intrathecal baclofen administered by the Medtronic SyncroMed(TM) pump (ITB)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Mucopolysaccharidosis II
Long-term Follow-Up for RGX-121
RGX-121-5101 is an observational long-term follow-up study to the RGX-121-101 or RGX-121-1102 studies where participants received RGX-121, a gene therapy intended to deliver a functional copy of the iduronate-2-sulfatase gene…
- Trial name
- NCT04597385
- Testing
- Long-term Follow-Up
- Where
- 4 sites in United States, Brazil
- Volunteers
- 27 people
- Sponsor
- REGENXBIO Inc.
Disability Physical, Stroke
Comparing the Responsiveness of Barthel Index and Longshi Scale in Assessing the ADL of Stroke Survivors
The aim of this research was to compare the responsiveness of Barthel Index (BI) and Longshi Scale (LS) for assessing activities of daily living (ADL) in stroke survivors at different stage and we also aimed to observe changes of…
- Trial name
- NCT05150743
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shenzhen Second People's Hospital
Prader-Willi Syndrome, Obesity
Improving Care of Prader-Willi Syndrome : Evaluation of a New Care Program Combining Adapted Physical Activity, Nutrition and Therapeutic Education
Prader-Willi syndrome (PWS) is a rare and complex genetic disease characterized by hypothalamic-pituitary axis dysfunction combining eating disorders associated with hyperphagia and satiety deficiency, mild intellectual deficit…
- Trial name
- APHYNET (NCT05249998)
- Testing
- Program combing APA, Nutrition, and Therapeutic Education
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis (MS), Telenursing
TELESM-edu.Nursing: a Personalised Nursing Intervention for People With Multiple Sclerosis
The primary aim of this study is to evaluate the impact of the telenursing intervention "TELESM-edu.nursing" on people with Multiple Sclerosis (pwMS), specifically focusing on their navigational capacity within the healthcare…
- Trial name
- TELESM-edu (NCT07640698)
- Testing
- TELESM-edu.nursing, Standard
- Volunteers
- 110 people
- Sponsor
- G. d'Annunzio University
Autism Spectrum Disorder, Teacher Training
Implementation of a Teacher Classroom Program to Support Preschool Children With Autism or Developmental Problems
The Incredible Years® "Helping Preschool Children with Autism" (IY-HPCA) program is designed for teachers of children aged 2 to 5 years who have students with autism in their classrooms.
- Conditions
- Autism Spectrum Disorder, Teacher Training, Teacher Skills in Addressing Child Mental Health Problem, Developmental Disorders
- Trial name
- NCT06790199
- Testing
- Incredible Years® "Helping Preschool Children with Autism" program (IY-HPCA)
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundació Sant Joan de Déu
Psoriasis Vulgaris
Pre-Post Multimodal Assessment Of Severe Psoriasis Vulgaris Using Clinical, Dermoscopic And QoL Measures
The goal of this observational study is to learn about the comprehensive changes in severe plaque psoriasis (Psoriasis Vulgaris) in adult participants undergoing standard treatment.
- Trial name
- NCT07495657
- Volunteers
- 45 people
- Sponsor
- Assiut University
Low Back Pain, Chronic
Person-Centered Lifestyle Redesign in Chronic Low Back Pain
This study is designed to examine the effects of a person-centered lifestyle intervention on pain, occupational performance, quality of life, disability, physical activity levels, and mental status in individuals with chronic low…
- Trial name
- NCT07163546
- Testing
- Lifestyle intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Participation, Patient, Child, Only
Turkish Version of the "Children's Assessment of Participation With Hands Scale
To the best of our knowledge, there is no Turkish validity and reliability scale that can reveal children's hand involvement. In the study in which the CAP-H was developed, it was stated that this scale could be used in…
- Trial name
- NCT04904848
- Testing
- Survey evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 182 people
- Sponsor
- Pamukkale University