Clinical trials: Disability, Evaluation
Child Development Disorder, Child Development
Investigation of the Usability of the Dynamic Scaffolding System
The aim of the present study was to compare the duration of use of the Dynamic Scaffolding System (DSS) in children with different levels of motor impairment, to report adverse events during use, and to examine parental…
- Conditions
- Child Development Disorder, Child Development, Assistive Technology
- Trial name
- NCT05727046
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Karadeniz Technical University
Non-specific Low Back Pain (NSLBP)
Effects Of Sahrmann's Versus McGill Exercise In Patients With Non-Specific Low Back Pain
The goal of this clinical trial is to learn whether Sahrmann exercises or McGill exercises are more effective for reducing pain and improving function in adults with non-specific low back pain.
- Trial name
- NCT07659327
- Testing
- Sahrmann's Exercises, McGill Exercises
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Lipedema, Venous Insufficiency
Assessment of Venous Insufficiency and Clinical Features in Lipedema
Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment.
- Conditions
- Lipedema, Venous Insufficiency, Venous Disease, Disability Physical
- Trial name
- NCT07603076
- Testing
- Venous Doppler Ultrasonography, Numeric Rating Scale, Lower Extremity Functional Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Dyslexia
Evaluation of Speech Rhythm Training in Dyslexic Readers Aged 7 to 9 Years
Studies of dyslexia have shown altered oscillatory activity in the low gamma band (~25-35 Hz) in the left auditory cortex. Neural oscillations around 30 Hz constitute the basic sampling rate of speech, from which the ability to…
- Trial name
- RnDys (NCT05996497)
- Testing
- behavioral measures, Electrophysiological measures, Training 1
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Institut Pasteur
Mucopolysaccharidosis Type II, Metabolic Diseases
A Multi-cohort Study of the Tolerance, Safety, and Pharmacokinetics of GNR-055 in Healthy Volunteers
It is a phase I open-label single-dose, dose-escalation cohort study to evaluate of the tolerance, safety, and pharmacokinetics of GNR-055 in healthy volunteers
- Trial name
- NCT04539340
- Testing
- GNR-055
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Transition-age Youth, Developmental Disabilities
Evaluation of Project TEAM (Teens Making Environmental and Activity Modifications)
The purpose of this study is to determine the extent to which Project TEAM (Teens making Environment and Activity Modifications) is an effective, socially valid, and feasible intervention that prepares youth with developmental…
- Conditions
- Transition-age Youth, Developmental Disabilities, Cerebral Palsy, Autism
- Trial name
- ProjectTEAM (NCT02714868)
- Testing
- Project TEAM, Matched Comparison
- Volunteers
- 82 people
- Sponsor
- Boston University Charles River Campus
Neurodevelopmental Cognitive, Motor and Speech-language Disabilities
Assessment and Telerehabilitation of Cognitive and Motor Skills in Children With Neurodevelopmental Disabilities (Tablet Project)
The development and application of new technologies to support functional assessment and rehabilitation pathways for neurodevelopmental disabilities allow the evaluation and enhancement of cognitive, motor, and speech abilities…
- Trial name
- NCT06290297
- Testing
- Telerehabilitation VRRS
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- IRCCS Fondazione Stella Maris
Disability Physical, Neck Pain
Evaluation of the Relationship Between Neck Pain and Ergonomic Factors in Office Workers
Neck pain is a prevalent condition and leading causes of disability particularly in office workers compared to other occupations (1-3).
- Conditions
- Disability Physical, Neck Pain, Ergonomic Factors
- Trial name
- NCT04803760
- Testing
- A self-administered questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 1,028 people
- Sponsor
- Istanbul University
Shoulder Impingement Syndrome
Title of This Study is to Evaluate the Effects of Abdominal Drawing in Maneuver With Cross Pattern Limb Exercises in Patients With Subacromial Impingement Syndrome
SUMMARY : Introduction: Shoulder impingement syndrome is a slowly progressive disease.Among people with shoulder pain, shoulder impingement syndrome (SIS) has the highest prevalence and accounts for 36% of shoulder disorders.Most…
- Trial name
- NCT07521839
- Testing
- Abdominal Drawing Inn maneuver with cross pattern limb exercises, Shoulder Exercises
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Superior University
X-Linked Adrenoleukodystrophy (X-ALD), Cerebral Adrenoleukodystrophy (CALD)
Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD)
Study ALD-103 will be a multi-site, global, prospective and retrospective data collection study that is designed to evaluate outcomes of allo-HSCT in male subjects with CALD ≤17 years of age.
- Conditions
- X-Linked Adrenoleukodystrophy (X-ALD), Cerebral Adrenoleukodystrophy (CALD), Adrenoleukodystrophy (ALD)
- Trial name
- NCT02204904
- Testing
- Allo-HSCT
- Where
- 13 sites in United States, Argentina and 5 more
- Volunteers
- 59 people
- Sponsor
- Genetix Biotherapeutics Inc.
Down Syndrome, Amyloid Beta-protein
Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid.
To determine the sensitivity of the visual assessment of BAY94-9172 PET images in detecting cerebral β-amyloid in individuals with Down Syndrome (DS) and specificity in individuals without DS.
- Trial name
- NCT00928304
- Testing
- Florbetaben (BAY94-9172)
- Where
- 2 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Lantheus Biosciences Ltd.
Disability Evaluation, Recovery of Function
Effectiveness of VR Rehabilitation for People With Asymmetrical Gait Patterns
A randomized comparative study will be conducted to evaluate the rehabilitation process using a VR-based application versus conventional therapy in 40 patients (sample size determined using a sample size calculator).
- Conditions
- Disability Evaluation, Recovery of Function, Rehabilitation
- Trial name
- NCT07568821
- Testing
- Virtual Reality (VR) and Standard Rehabilitation, Standard Rehabilitation
- Volunteers
- 40 people
- Sponsor
- University of Rzeszow
Episodic Migraine, Chronic Migraine
CGRP Inhibition, Autonomic Function, and Migraine
The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e.
- Trial name
- CGRP-1 (NCT04628429)
- Testing
- Erenumab, Galcanezumab, Fremanezumab
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Down Syndrome
Early Ultrasound and Maternal Biochemical Markers to Evaluate the Risk of Down Syndrome During the First Trimester
The aim of the study is to evaluate the risk of Down syndrome during the first trimester of the pregnancy. The risk assessment is evaluated using early ultrasound and maternal biochemical markers.
- Trial name
- NCT00287417
- Testing
- echography, blood sample
- Where
- 7 sites in France
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Movement Disorders
Effectiveness of a Wheelchair Skills Training Program for Power Mobility Users: A Randomized Controlled Trial
This is a 3-year multi-centre, single-blinded, randomized controlled trial (RCT) to test the hypothesis that wheelchair skills training (using a systematic training program called the Wheelchair Skills Training Program) improves…
- Trial name
- NCT01432418
- Testing
- Wheelchair skills training program
- Where
- 6 sites in Canada
- Volunteers
- 116 people
- Sponsor
- Nova Scotia Health Authority
Intellectual Disability
Various Type of Genetic Events in Patients With Intellectual Disability
Currently, for a patient with intellectual disability without a recognizable syndrome (most cases), the way to diagnosis is often long, tedious and expensive because different approaches are used one after the other to identify…
- Trial name
- CNV-Seq (NCT02881333)
- Testing
- Blood samples
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Specific Learning Disorder
Fine Motor Function in Children With Specific Learning Disorders
Specific Learning Disorder (SLD) is a neurodevelopmental disorder in which a person shows difficulties in reading, written narration, and/or mathematics.
- Trial name
- NCT05902143
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Fragile X Syndrome (FXS), Autism Spectrum Disorder (ASD)
A Study to Investigate the Effects and Safety of Codabakalner for the Treatment of FXS in Male Participants and Adult Participants With ADS
This is a Study to Investigate the Effects and Safety of Codabakalner for the Treatment of Fragile X Syndrome in Male Participants and Adult Participants with Autism Spectrum Disorders
- Trial name
- NCT07439510
- Testing
- Codabakalner
- Volunteers
- 120 people
- Sponsor
- Spinogenix
Mucopolysaccharidosis II
Safety and Efficacy of HMI-203 in ERT-Treated Adults With MPS II
Phase 1, open-label, sequential ascending dose-escalation study. Designed to evaluate the safety and efficacy of a single IV infusion of investigational gene therapy HMI-203.
- Trial name
- NCT05238324
- Testing
- Genetic HMI-203
- Where
- 6 sites in United States, Canada
- Sponsor
- Homology Medicines, Inc
Low Back Pain, Non Specific Chronic Low Back Pain
Effects of Multifidus Lift Exercise on Endurance, Pain, and Disability in University Students With Low Back Pain
Nonspecific low back pain is a common musculoskeletal problem that also affects many young adults, including university students. It can negatively impact academic performance, daily life, and overall well-being.
- Conditions
- Low Back Pain, Non Specific Chronic Low Back Pain, Healthy Vollunteer
- Trial name
- LBP-MULEX (NCT07182825)
- Testing
- Modified Multifidus Lift Exercise (MLE)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Guler