Clinical trials: Disc Herniations
Adult Spinal Deformity, Degenerative Scoliosis
Gait and Paraspinal sEMG in Degenerative Spinal Diseases
This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal…
- Conditions
- Adult Spinal Deformity, Degenerative Scoliosis, Sagittal Deformity, Sagittal Imbalance
- Trial name
- TDGKSEPDSD (NCT07309926)
- Testing
- Gait analysis and surface electromyography analysis
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Herniated Disc, Sciatica
Intradiscal Discogel® in Resistant Sciatica
Sciatica due to herniated disc is a major cause of disability in young adults. Surgery is the gold-standard and the only controlled treatment in case of failure of conservative treatment.
- Conditions
- Herniated Disc, Sciatica, Persistent Pain, Leg
- Trial name
- EDIS (NCT02313350)
- Testing
- Chemonucleolysis with Discogel, open discectomy
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Sciatica, Foot Deformity
Foot Orthoses in Patients With Sciatica
Chronic sciatica is a frequent problem whose symptoms could be related to the abnormal stresses applied to the musculoskeletal system during the gait cycle due to foot alterations.
- Trial name
- NCT05129540
- Testing
- Custom-made foot orthosis
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Seville
Lumbar Disc Herniation, Postoperative Pain
Comparison of the Effects of Quadratus Lumborum Block and Retrolaminar Block on Postoperative Pain in Lumbar Disc Herniation Surgery
This study aims to compare the analgesic efficacy of quadratus lumborum block (QLB) and retrolaminar block (RLB) in patients undergoing lumbar disc herniation surgery.
- Trial name
- NCT07166250
- Testing
- Quadratus Lumborum Block, Retrolaminar Block
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Kocaeli University
Sciatica
Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation
The primary objective of the study is to evaluate the safety and efficacy of CEP-37247 compared with placebo as assessed by the occurrence of adverse events, and the mean change in average pain intensity (API) in the affected leg.
- Trial name
- NCT01240876
- Testing
- CEP-37247
- Where
- 24 sites in United States, Australia
- Volunteers
- 98 people
- Sponsor
- Cephalon
Disc Herniation
Comparison of the Effectiveness of Reformer Pilates and Conventional Physiotherapy in Lumbar Disc Herniation
This study aims to examine the effects of Reformer Pilates on patient-reported outcomes such as pain level, fatigue, sleep quality, anxiety, kinesiophobia, and quality of life in individuals with lumbar disc herniation (LDH) and…
- Trial name
- NCT06846892
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yasemin Şahbaz
Lumbar Herniated Intervertebral Disc
Biportal Endoscopic Discectomy Versus Microdiscectomy: RCT, Non-inferiority Trial
This study is to compare the clinical outcome between the biportal endoscopic discectomy and microdiscectomy in herniated intervertebral disc of lumbar spine
- Trial name
- BESS (NCT03924700)
- Testing
- Biportal endoscopy, Microdiscectomy
- Where
- 2 sites in South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Hospital
Pain, Lumbar Disc Herniation
The Diagnostic and Prognostic Value of Two Quantitative Clinical Tests in Patients With Lumbar Disc Herniation
This study will investigate whether two clinical tests can be used to diagnose and predict the outcome in patients with lumbar disc herniation undergoing surgery and non-surgery treatment.
- Conditions
- Pain, Lumbar Disc Herniation, Back Pain, Spinal Diseases
- Trial name
- NCT03832036
- Testing
- Paraspinal Mapping and Quantitative Sensory Pain Test
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Spine Centre of Southern Denmark
Pain, Neck
Clinical Effects of Ozone Therapy in Cervical Disc Hernia
The aim of the study is to evaluate the clinical effects of Ozone-oxygen therapy as therapeutic substance for nucleolysis application in the patients with cervical disc hernia who had chronic pain and weakness on the neck…
- Trial name
- NCT03056911
- Testing
- Ozone
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Sakarya University
Herniated Lumbar Disc
High Power Laser Therapy for Herniated Disc and Lumbosacral Radiculopathy
To determine the effect of high-power laser therapy on the size of herniated disc and functional outcome in patients with lumbosacral radiculopathy.
- Trial name
- NCT06831227
- Testing
- High power Laser Therapy, physical therapy exercise program and hot pack
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Lumbar Disc Herniation, Acute Pain
Short-Term Effects of Dynamic Taping in Patients With Lumbar Disc Herniation
Previous evidence has shown that kinesio tape application reduces pain levels and improves disability in patients with chronic low back pain due to lumbar disc herniation.
- Trial name
- NCT05940519
- Testing
- Dynamic taping technique
- Volunteers
- 34 people
- Sponsor
- NAİME ULUG
Surgical Wound Infection
Study of the Efficacy of Preoperative Cefuroxime Prophylaxis to Prevent Surgical Site Infection in Herniated Disk Surgery
The purpose of the study is to determine whether a single, pre-operative dose of cefuroxime is effective in preventing surgical site infection in patients undergoing surgery for herniated disk
- Trial name
- NCT00530400
- Testing
- cefuroxime
- Where
- 2 sites in Switzerland
- Volunteers
- 1,369 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Low Back Pain and Core Muscle, Disc Herniation
Neural Control and Mechanosensation in Spine Muscle
Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization.
- Trial name
- NCT07003802
- Testing
- Resistance exercise
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Paresis, Lumbar Disc Herniation
Validation of a Methodology Using Isometric Dynamometer for Ankle STrength Assessment to Quantify LDH-induced Paresis
Lumbar disc herniation (LDH) is a common condition that may cause lower limb motor weakness (paresis), particularly affecting ankle dorsiflexion and plantarflexion.
- Trial name
- VAST-LDH (NCT07763522)
- Testing
- Strength test validity and reliability
- Where
- Finland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Lumbar Disc Herniation
Comparative Study Between UBE and PETD for the Treatment of Lumbar Spinal Canal Stenosis
OBJECTIVE Both unilateral biportal endoscopy technique(UBE) and percutaneous endoscopic transforaminal discectomy(PETD) are minimally invasive and effective surgical procedures for lumbar spinal stenosis.The object of this…
- Trial name
- NCT05033457
- Testing
- unilateral biportal endoscopy technique or percutaneous endoscopic transforaminal discectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shaanxi Provincial People's Hospital
Radiculopathy, Spinal Stenosis
Steroid Injections Given at the "Level of MRI Pathology" Versus at the "Level of Clinical Symptoms" to See if One is More Effective Than the Other.
Patients are being asked to participate in a research study because the patients are being treated for low back pain and the patients have decided to have an epidural steroid injection.
- Conditions
- Radiculopathy, Spinal Stenosis, Intervertebral Disc Displacement
- Trial name
- NCT02196883
- Testing
- Transforaminal Epidural Steroid Injection
- Where
- United States
- Sponsor
- State University of New York - Upstate Medical University
Lumbar Disc Herniation, Degenerative Disc Disease
Peri-Incisional Drug Injection in Lumbar Spine Surgery
This is a randomized prospective study that will compare the use of narcotics in a control group of non-injected patients with a treatment arm of patients injected intra-operatively with a ropivacaine, morphine, and epinephrine…
- Conditions
- Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
- Trial name
- NCT03513445
- Testing
- Morphine, Epinephrine, naropin
- Where
- United States
- Sponsor
- University of Minnesota
Cervical Foraminal Stenosis, Cervical Disc Herniation
Safety and Efficacy of Electromagnetic Navigation System Assisted Percutaneous Endoscopic Lumbar Decompression
There is a shallow learning curve with TELD (transforaminal endoscopic lumbar discectomy). The aim of this study is to assess the safety and efficacy of TELD assisted by electromagnetic navigation for treating lumbar disc…
- Trial name
- NCT05270486
- Testing
- Electromagnetic navigation system
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Régional de la Citadelle
Lumbar Herniated Disc
Percutaneous Transforaminal Endoscopic Discectomy vs Microendoscopic Discectomy for Treatment of Lumbar Disc Herniation
The purpose of this study is to evaluate the effectiveness of two minimal invasive endoscopic discectomy, PTED and MED, for the treatment of symptomatic lumbar disc herniation.
- Trial name
- NCT01997086
- Testing
- Percutaneous transforaminal endoscopic discectomy (PTED), Microendoscopic discectomy (MED)
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Infection, Intervertebral Disc Herniation
Subclinical Propionibacterium Acnes Infection Estimation in the Intervertebral Disc (SPInE-ID)
Subclinical infection of the intervertebral disc after lumbar disc herniation surgery has been correlated to chronic low back pain and vertebral endplate changes. The most commonly reported agent is Propionibacterium acnes.
- Conditions
- Infection, Intervertebral Disc Herniation, Propionibacterium Infection, Spinal Diseases
- Trial name
- SPInE-ID (NCT03158766)
- Testing
- Microdiscectomy
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- Hospital Israelita Albert Einstein