Clinical trials: Discontinuation
Mouth Diseases
Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene
The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days.
- Trial name
- NCT02913235
- Testing
- Oral hygiene discontinuation group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Menopause
Study of Paxil Use in Menopausal Women
To evaluate the efficacy, safety, and tolerability of Paroxetine treatment in perimenopausal and postmenopausal women who present with menopause-related symptoms after discontinuing hormone therapy (HT), in the presence or…
- Trial name
- NCT00225914
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cancer, End Stage Cancer
Information Needs Around Parenteral nUTrition in Cancer
This study will explore the information needs of patient's with advanced cancer, and their carers, when making a decision to commence or discontinue parenteral nutrition.
- Conditions
- Cancer, End Stage Cancer, Terminal Cancer, Neoplasms
- Trial name
- INPUT (NCT04495530)
- Testing
- Non-interventional study
- Where
- 4 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Infertility
Psychosocial Determinants of Continuing or Discontinuing Infertility Treatment: A Psychological Analysis
The current study aims to explore and analyse the decision making process of couples in regards to continuing or discontinuing infertility treatment.
- Trial name
- NCT00974649
- Testing
- self-report questionnaire
- Where
- Belgium
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
End of Life
Impact of a Protocol for Announcing Decision of Withholding and Withdrawing Life-sustaining Treatments on the Stress of the Relatives in the Emergency Departments
Death is a daily reality in the emergency department. Deaths represent 0.3 to 0.5% of emergency admissions, i.e. approximately 26,000 per year for the whole of France.
- Trial name
- DISCUSS (NCT06071078)
- Testing
- Training of professionals according to the DISCUSS announcement protocol
- Where
- 9 sites in France
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Myopia
Discontinuation of Lens Wear in New Ortho-k Children (DOEE2)
This study aims at investigating the efficacy of myopic control using ortho-k in younger and older children.
- Trial name
- DOEE2 (NCT01236755)
- Testing
- single-vision glasses, ortho-k lenses
- Where
- China
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Treatment Free Remission, Chronic Myeloid Leukemia
Italian Treatment Free Remission Registry
The investigator propose an extension of the previous National, multicentric study, promoting an observational registry, both retrospective and prospective, in order to expand and further characterize the series of Italian…
- Trial name
- NCT04769947
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
BPH
Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term Study
Comparison between tamsulosin and Tadalafil in management of benign prostatic hyperplasia A Randomised Trial
- Trial name
- NCT05818670
- Testing
- Tamsulosin, Tadalafil
- Where
- 2 sites in Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Myopia
Discontinuation of Orthokeratology on Eyeball Elongation in Myopic Children
The primary aim of this study is to compare eyeball elongation in existing ortho-k subjects who stop the treatment with subjects who continue ortho-k lens wear and control subjects wearing single-vision glasses.
- Trial name
- DOEE1 (NCT01236742)
- Testing
- ortho-k lenses, single-vision glasses
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Labor Pain, Pregnancy
The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery
The objective of this study will be to compare epidural infusion management, specifically looking at infusion rate changes, in patients who receive forceps deliveries versus normal spontaneous vaginal deliveries.
- Trial name
- NCT00443560
- Testing
- Case controlled analysis of epidural labor analgesia patterns
- Where
- United States
- Volunteers
- 2,162 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lactose Intolerance
Does Daily Supplementation of Lactobacillus Acidophilus MPH734, for One Week, Affect Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo
The purpose of this study is to determine if twice or three times daily supplementation of Lactobacillus acidophilus MPH734 (Lacto-FreedomTM, or LF), for one week, affects acute (immediate), subacute (7 days), and post-treatment…
- Trial name
- LF (NCT04531033)
- Testing
- Lactobacillus acidophilus MPH734
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lemuel W. Taylor IV
MDMA Discontinuation Syndrome
Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.
The purpose of this study is to measure the effects of MDMA on sleep, mood, thinking, and how your body retains water. The researchers are interested in the effects that occur a few hours after taking MDMA as well as effects…
- Trial name
- 2C (NCT01053403)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- California Pacific Medical Center Research Institute
Psychosis
A Follow up Safety Study of Patients Who Participated in Previous Studies of the Drug Org 24448 (Study P05719)(COMPLETED)
This is a safety study evaluating the subjects who participated in previous Organon trials of the drug Org 24448. Patients will undergo a Screening visit, 1 or 2 Evaluation visits, and a possible Follow-Up period.
- Trial name
- NCT00780585
- Testing
- SCH 900460
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Patent Foramen Ovale, Ischemic Stroke
Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke
To determine the safety of antithrombotic treatment discontinuation 12 months following successful transcatheter PFO closure.
- Conditions
- Patent Foramen Ovale, Ischemic Stroke, Bleeding Ulcer
- Trial name
- HALTI (NCT04475510)
- Testing
- Antiplatelet treatment discontinuation
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josep Rodes-Cabau
Menopause, Atherosclerosis
Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life
Although the impact of postmenopausal hormone therapy (HT) on cardiovascular disease risk has been studied in several large randomized trials, little is known about the acute cardiovascular consequences of HT discontinuation.
- Conditions
- Menopause, Atherosclerosis, Cardiovascular Diseases, Estrogen Replacement Therapy
- Trial name
- NCT04050592
- Testing
- Estradiol
- Where
- Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hanna Savolainen-Peltonen
Contraceptive Device; Intrauterine
Discontinuation Rate Among Copper IUD Users
The intrauterine device (IUD) is one of the most widely used reversible, long-term contraceptive methods in the world. But despite all its advantages; discontinuation rate of IUD ranged from 9.6% to 37.3 % (according to…
- Trial name
- NCT03404102
- Testing
- Cu-IUD
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- noha mohamed elzaydy
Osteoporosis, Postmenopausal, Osteoporosis
Comparative Antiresorptive Efficacy Discontinuation of Denosumab
Osteoporosis remains a significant healthcare burden for the United States. Current FDA-approved osteoporosis treatments include teriparatide, abaloparatide, bisphosphonates, denosumab, and raloxifene.
- Trial name
- NCT03623633
- Testing
- denosumab, alendronate, raloxifene
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis, Autoimmune Diseases
One or Two Week Methotrexate Discontinuation on Efficacy of Influenza Vaccination in Rheumatoid Arthritis.
This is a multi-center, randomized, single-blinded, prospective, parallel group intervention study to investigate whether methotrexate (MTX) discontinuation for 1 week is non-inferior to MTX discontinuation for 2 weeks in regard…
- Conditions
- Rheumatoid Arthritis, Autoimmune Diseases, Influenza, Vaccine Reaction
- Trial name
- NCT05069714
- Testing
- MTX-hold
- Where
- 3 sites in South Korea
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
HIV Infections
The TAIL-PrEP Study
The goal of the TAIL-PrEP study is to understand how to support the safe discontinuation of injectable long-acting cabotegravir (cab-LA) and lenacapavir (LEN) while maximizing the public health impact of biomedical HIV prevention…
- Trial name
- NCT06868641
- Testing
- TAIL-PrEP for patients discontinuing cab-LA, TAIL-PrEP for patients considering discontinuing cab-LA, TAIL-PrEP for patients considering discontinuing LEN
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Columbia University
Contraception Behavior
Premature Discontinuation of Contraceptive Implants
To compare rates of etonogestrel implant discontinuation in implant initiators who are given advance provision of combined oral contraceptive pills (COCs) and a bleeding rescue regimen (COCR intervention) to participants given…
- Trial name
- NCT04828824
- Testing
- Ethinyl Estradiol / Norgestimate Oral Tablet
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver