Clinical trials: Disease;Neurological
Anxiety, Depression Disorders
Enhanced Ward Rounds and Communication for Pre-procedural Anxiety in GI Endoscopy Patients
This study tests a new way to help reduce anxiety in hospitalized patients waiting for therapeutic gastrointestinal (GI) endoscopy procedures, like EMR or ESD.
- Conditions
- Anxiety, Depression Disorders, Sleep Wake Disorders, Gastrointestinal Diseases
- Trial name
- NCT07286877
- Testing
- Enhanced Ward-Round Frequency With Standardized Communication, Usual Care Ward Rounds (2/day)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- LanZhou University
Strabismus, Retinal Thickening
Choroidal and Retinal Thickness Following Strabismus Surgery
Prospective study, conducted at Tanta University Ophthalmology Department Measurement of macular and choroidal thickness before and after strabismus surgery
- Trial name
- NCT04285177
- Testing
- Strabismus surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Stroke, Ischemic Stroke
Safety Study of Post Intravenous tPA Monitoring in Ischemic Stroke
Intravenous (IV) tissue plasminogen activator (tPA) is the only FDA-approved therapy for treatment of acute ischemic stroke. In the United States, IV tPA is typically administered in the Emergency Department (ED) for patients…
- Trial name
- OPTIMIST (NCT02039375)
- Testing
- "Hopkins" post tPA for ischemic stroke monitoring protocol
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Post-operative Pain, Spine, Open
The Effect of Press Needle in the Combination of Ear and Body Acupuncture Points on Visual Analog Scale in Post-Operative Patients of Open Spine Surgery
Postoperative pain is pain that arises after a surgical procedure, resulting from trauma during the surgical incision process. It is generally acute in nature and is accompanied by an inflammatory response.
- Trial name
- NCT06165575
- Testing
- Press needle
- Where
- 3 sites in Indonesia
- Volunteers
- 54 people
- Sponsor
- Universitas Indonesia
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma
Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma
This phase I/II trial studies the side effects and best dose of temsirolimus when given together with perifosine and to see how well it works in treating patients with recurrent or progressive malignant glioma.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Diffuse Astrocytoma, Adult Giant Cell Glioblastoma
- Trial name
- NCT01051557
- Testing
- Laboratory Biomarker Analysis, Perifosine, Temsirolimus
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Ischemic Stroke
Intra-arterial Bone-marrow Mononuclear Cells Infusion for Acute Ischemic Stroke
This trial aims to test that intra-arterial injection of autologous bone marrow mononuclear cells in acute ischemic stroke patients is safe and improves neurological outcomes.
- Trial name
- NCT02178657
- Testing
- Autologous bone marrow mononuclear cell intra-arterial injection
- Where
- 4 sites in Spain
- Volunteers
- 76 people
- Sponsor
- Andalusian Initiative for Advanced Therapies
Coma
Longitudinal Study of the Default-mode Network Connectivity in Brain Injured Patients Recovering From Coma
Several studies in healthy volunteers have suggested that the synchronized functional connectivity in the DMN (Deafult-Mode Network) would sustain the mental content at rest, and when required, a switch in the activity between…
- Trial name
- ACI-Coma (NCT01620957)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Multiple Sclerosis
Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue
The overarching aim is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers, [F-18]PBR06 and…
- Trial name
- NCT04144257
- Testing
- [F-18]PBR06, [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Ischaemic Stroke
Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial
When to start anticoagulation in patients with an acute ischaemic stroke and atrial fibrillation (AF) is a relevant unanswered question in clinical practice.
- Trial name
- ELAN (NCT03148457)
- Testing
- Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®), Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)
- Where
- 98 sites in Austria, Belgium and 13 more
- Volunteers
- 2,013 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Alzheimer's Disease
Evaluating Liraglutide in Alzheimer's Disease
This is a 12-month, multicentre randomised double-blind placebo-controlled Phase IIb study in patients with mild Alzheimer's dementia (AD). Patients will be randomised on a 1:1 ratio to receive liraglutide or matching placebo.
- Trial name
- ELAD (NCT01843075)
- Testing
- Liraglutide
- Where
- United Kingdom
- Volunteers
- 204 people
- Sponsor
- Imperial College London
Cancer, Brain Metastases, Adult
Re-TREAT: Re-irradiation for Relapsed Brain Metastases
The Re-TREAT study is a prospective clinical, phase 2, interventional, single-arm, multicenter trial for patients with local relapse of one or more brain metastases.
- Trial name
- RE-TREAT (NCT05126875)
- Testing
- Repeated stereotactic radiosurgery
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Blindness, Legal
Functional Assessment Questionnaire for the Visually Challenged
The purpose of this research is to evaluate how accurately a proposed "Functionality Assessment Questionnaire" measures the differences between low-functioning and high-functioning visually challenged individuals who are legally…
- Trial name
- NCT00407901
- Volunteers
- 31 people
- Sponsor
- George Washington University
Hydrocephalus
Improving Infant Hydrocephalus Outcomes in Uganda
Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and…
- Trial name
- NCT03650101
- Testing
- ETV/CPC
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 400 people
- Sponsor
- Boston Children's Hospital
Parkinson's Disease
Study of Tai Chi Exercise and Balance in Persons With Parkinson's Disease
Patients practicing Tai Chi will exhibit significant improvements in primary outcome measures of balance, and secondary outcomes of gait, physical performance, Unified Parkinson's Disease Rating Scale, Falls, muscle strength.
- Trial name
- NCT00611481
- Testing
- Tai Chi, Strength training, Low-Impact Exercise Control
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Oregon Research Institute
Hypoxic-Ischemic Encephalopathy, Cardiac Arrest
Propofol-induced EEG Changes in Hypoxic Brain Injury
PROPEA3 is a prospective observational study investigating the recovery of propofol-induced EEG slow-wave activity and its association with neurological outcome after cardiac arrest.
- Trial name
- PROPEA3 (NCT03485781)
- Where
- 2 sites in Finland
- Volunteers
- 102 people
- Sponsor
- University of Oulu
Hearing Loss
Orientation for Hearing Aid Users: Information Retention
Aim: To verify how much of the orientation provided at diagnosis and hearing aid fitting are retained by new hearing aid users and analyze whether age, degree of hearing loss, academic and socio-economics status have an influence…
- Trial name
- NCT01017419
- Testing
- Counseling
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Postural Tachycardia Syndrome, Orthostatic Intolerance
Peripheral Dopamine in Postural Tachycardia Syndrome
The purpose of the proposed research is to determine how changes in kidney dopamine (DA) activity influence urinary sodium excretion.
- Trial name
- NCT00685919
- Testing
- Carbidopa
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Multifocal Motor Neuropathy (MMN), Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Do IgG Level Variations in CIDP and MMN Patients Following Initial Intravenous IVIg Treatment Correlate With Ultimate Dosing
CIDP and MMN are part of a group of chronic inflammatory conditions that affect the peripheral nervous system. In CIDP, there is chronic inflammation of the peripheral nerves and nerve roots leading to demyelination.
- Trial name
- digG (NCT04356781)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Walton Centre NHS Foundation Trust
Ischemic Stroke, Acute
Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial
Several clinical trials have produced variable conclusions regarding the effects of intensive blood pressure (BP) lowering in post-EVT acute ischaemic stroke (AIS) patients.
- Trial name
- ENCHANTED3/MT (NCT06352619)
- Testing
- Conservative SBP Control, Moderate SBP Control, Intensive SBP Control
- Where
- 2 sites in Australia, Canada
- Volunteers
- 2,000 people
- Sponsor
- The George Institute
Multiple Sclerosis
Paris Visual Learning Test: a New French Task for Assess Visual Learning and Memory to Multiple Sclerosis Patients
Cognitive impairment affects up to 65% of multiple sclerosis (MS) subjects, especially memory function. Rothschild Foundation has developped the Paris Visual Learning and memory Test (PVLT).
- Trial name
- valid-PVLT (NCT02893683)
- Testing
- Paris Visual Learning Test
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
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