Clinical trials: Disease;Neurological
Brain Metastases
Evaluating AGuIX® Nanoparticles in Combination With Stereotactic Radiation for Brain Metastases
This study evaluates the clinical impact of AGuIX® nanoparticles in combination with Fractionated Stereotactic Radiation in oligo brain metastases.
- Trial name
- NANOSTEREO (NCT04094077)
- Testing
- AGuIX
- Where
- 2 sites in France
- Volunteers
- 1 people
- Sponsor
- Centre Leon Berard
Focus: Anabolic Response to Food Intake in Young Individuals, Condition Relevance: Skeletal Muscle Health, Sarcopenia
Manipulation of Dietary Protein and the Anabolic Response
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.
- Trial name
- PRO-ADAPT (NCT01820975)
- Testing
- High protein intake
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetic Peripheral Neuropathy (DPN), Paresthesia
Study of Acetyllevocarnitine Hydrochloride Tablets in Chinese Patients With Paresthesias Caused by DPN
The purpose of this study is to assess the efficacy of Acetyllevocarnitine Hydrochloride Tablets compared with placebo after 24 weeks, in chinese patients with paresthesia caused by Diabetic Peripheral Neuropathy (DPN).
- Trial name
- NCT05319275
- Testing
- Acetyllevocarnitine Hydrochloride Tablets
- Where
- 34 sites in China
- Volunteers
- 516 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Addiction Opiate, Chronic Pain
Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population
This is a randomized controlled trial. Patients will be randomly assigned to either the control or treatment group, with equal allocation using block randomization.
- Conditions
- Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
- Trial name
- SUPER-ERAS (NCT04464512)
- Testing
- Sufentanil
- Where
- United States
- Sponsor
- West Virginia University
Tumor, Brain, Tumor, Breast
Microscopy Imaging of Whole-mount Stained Human Tissues
The goal of this clinical trial is to develop an imaging platform for intraoperative tumor margin delineation in 250 cases of tumor-suffered patients.
- Conditions
- Tumor, Brain, Tumor, Breast, Tumor Skin
- Trial name
- NCT05689112
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Learning Disabilities
Action Medical Research
Learning disability affects 3% of the population. Severe types of learning disability are more likely to have an underlying genetic cause but diagnosis is difficult because many different genetic abnormalities may be involved.
- Trial name
- NCT02227381
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- Manchester University NHS Foundation Trust
Disorder of Consciousness
rTMS and EEG in DOC Patients
Background: Severe brain injury could cause chronic disorders of consciousness (DOC). Treating DOC patients to improve recovery remains very challenging.
- Trial name
- NCT04401319
- Testing
- DLPFC Stimulation for Crossover Study, AG Stimulation for Crossover Study, DLPFC Stimulation for Parallel Study
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 90 people
- Sponsor
- University of Liege
Fibromyalgia
Mindfulness Intervention for Fibromyalgia Delivered Through a Smartphone App
The purpose of this pilot feasibility study is to evaluate the effects of a smartphone-based mindfulness intervention (MBI) on pain-related outcomes in individuals with fibromyalgia.
- Trial name
- Fibroapp (NCT07032519)
- Testing
- Mindfulness Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Brigham and Women's Hospital
Acute Pain
Open Label Placebo to Reduce Prescription Opioid Use
The goal of the proposed study is to examine the efficacy of using an honest placebo to relieve pain for patients with an acute pain condition.
- Trial name
- NCT05014230
- Testing
- Opioid medication as part of standard care
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Brown University
Sleep Apnea, Obstructive, Anovulation
Using CPAP to Improve Menstruation in Women With Polycystic Ovarian Syndrome and Obstructive Sleep Apnea
The purpose of this study is to determine if treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure in women with both OSA and polycystic ovarian syndrome will improve the regularity of the women's…
- Conditions
- Sleep Apnea, Obstructive, Anovulation, Polycystic Ovarian Syndrome
- Trial name
- NCT03155828
- Testing
- CPAP
- Where
- United States
- Sponsor
- University of Louisville
Sleep Apnea Syndromes, Heart Failure
The Role of Sleep Disordered Breathing in Heart Failure Admissions
The purpose of this study is to evaluate the effect of in-hospital diagnosis and treatment of sleep disordered breathing (SDB) on post-discharge mortality and readmissions in- hospitalized patients with acute heart failure…
- Trial name
- NCT02505867
- Testing
- Adaptive Servo Ventilation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rami Khayat
Neuropathic Pain
The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
Pain as a result of nerve injury (neuropathic pain) is a particularly severe form of chronic pain. Common examples of neuropathic pain are pain due to diabetes and shingles.
- Trial name
- NCT01669967
- Testing
- Lidocaine, Diphenhydramine
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Brain and Central Nervous System Tumors
Temozolomide + Everolimus in Newly Diagnosed, Recurrent, or Progressive Malignant Glioblastoma Multiforme
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00387400
- Testing
- everolimus, temozolomide, microarray analysis
- Where
- 9 sites in Canada
- Volunteers
- 32 people
- Sponsor
- NCIC Clinical Trials Group
Sleep Apnea, Obstructive
The Effects of Trazodone on Sleep Apnea Severity
In Obstructive sleep apnea (OSA), the upper airway closes over and over again during sleep. This leads to disrupted sleep (waking up during the night), daytime sleepiness, and an increased risk for developing high blood pressure.
- Trial name
- NCT01817907
- Testing
- Trazodone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Moyamoya Disease, Moyamoya Syndrome
Development and Validation of Risk Prediction Models for Stroke and Cognitive Impairment in Moyamoya Disease and Moyamoya Syndrome
This multicenter prospective observational cohort study aims to develop and validate individualized risk prediction models for stroke and cognitive decline in patients with moyamoya disease or moyamoya syndrome by integrating…
- Trial name
- NCT07894107
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tiantan Hospital
Infant Development, Hemiplegia
CIMT and taVNS for Hemiplegia in Infants
Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body.
- Conditions
- Infant Development, Hemiplegia, Constraint Induced Movement Therapy
- Trial name
- NCT05101707
- Testing
- transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical University of South Carolina
Traumatic Brain Injury
Analysis and Valuation of the Expertise of Use of the Close Friends of People Victims of Traumatic Brain Injury
Post-traumatic behavioral disorders : analysis and valuation of the expertise of use of the close friends of people victims of traumatic brain injury.
- Trial name
- AVEC-TC (NCT02341092)
- Testing
- Traumatic brain injury
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Angers
Spinal Cord Injury
Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition
The study will be conducted in two steps: 1. Determination of the Minimal Effective Dose (MED) among the four doses of the panel 2. Estimation of the probability of response associated to the MED.
- Trial name
- RILUSCI (NCT02859792)
- Testing
- Riluzole, Blood Samples
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
ADNP, Helsmoortel-Van Der Aa Syndrome
ADNP Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing ADNP-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
ADNP, also known as Activity Dependent Neuroprotective Protein, is a rare neurodevelopmental disorder caused by mutations encompassing the ADNP gene on chromosome 20.
- Conditions
- ADNP, Helsmoortel-Van Der Aa Syndrome, Autism Spectrum Disorder
- Trial name
- NCT03718936
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Vision Disorder
A Novel Acuity Testing Method
The purpose of this protocol is to develop a valid, reliable, better standardized, and more efficient test of visual acuity (ability to see fine details) for use in clinical trials.
- Trial name
- NCT00013936
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Eye Institute (NEI)
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