Clinical trials: Disease;Neurological
Multiple Sclerosis
Methylphenidate to Improve Balance and Walking in MS
Methylphenidate is an amphetamine-like psychomotor stimulant drug currently approved for the treatment of attention-deficit hyperactivity disorder (ADHD), postural orthostasis tachycardia syndrome and narcolepsy.
- Trial name
- NCT01896700
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Migraine Disorders
Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache
The purpose of this study is to determine which drug makes lower migraine headache
- Trial name
- NCT01791400
- Testing
- metoclopramide, injection,20mg, one time, Sumatriptan, injection, 6 mg, one time
- Where
- Iran
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Hyper IgD Syndrome, Mevalonate Kinase Deficiency
B7 Coreceptor Molecules in Hyper IgD Syndrome Form of Mevalonate Kinase Deficiency
The hyper IgD syndrome (HIDS) is an inflammatory disease caused by mevalonate kinase deficiency. There is no cure, and available treatments of HIDS febrile episodes have shown limited clinical efficacy.
- Trial name
- HIDS-MKD (NCT01568736)
- Where
- 4 sites in United States, Netherlands
- Sponsor
- Michigan Technological University
Stroke
Effects of Transcranial Magnetic Stimulation Associated to Sensory Therapy for Treatment of Motor Function of Upper Limb of Stroke Patients
The aim of this research will be to investigate in stroke patients whether upper limb motor function can be maximized in response to sensory stimulation by comparing protocols for the application of Transcranial Magnetic…
- Trial name
- NCT03329807
- Testing
- Transcranial Magnetic Stimulation, conventional sensory therapy
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Pernambuco
Chronic Neck Pain
Diaphragmatic Breathing and Electroacupuncture for Chronic Neck Pain
Chronic non specific neck pain is a prevalent musculoskeletal disorder with significant impact on pain, forward head posture, and neck disability.
- Trial name
- NCT07684092
- Testing
- physiotherapy care, diaphragmatic breathing, and electroacupuncture, physiotherapy care, simple focused breathing exercises, and electroacupuncture
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Posttraumatic Stress Disorder
Sleep-directed Hypnosis As A Complement To Cognitive Processing Therapy (CPT) In Treating Posttraumatic Stress Disorder (PTSD)
Sleep impairment is the most often reported of the 17 PTSD symptoms and is considered one of the most refractory to treatment. This study proposes the use of sleep-directed hypnotherapy to address sleep issues as a complementary…
- Trial name
- Hypnosis (NCT00725192)
- Testing
- Cognitive Processing Therapy, Hypnosis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Center for Trauma Recovery, St Louis
Chronic Troublesome Sialorrhea, Cerebral Palsy
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability
The objective of this study is to investigate the efficacy and safety of NT 201 compared with placebo for the treatment of chronic troublesome sialorrhea associated with neurological disorders (e.g.
- Conditions
- Chronic Troublesome Sialorrhea, Cerebral Palsy, Stroke, Traumatic Brain Injury
- Trial name
- SIPEXI (NCT02270736)
- Testing
- NT 201
- Where
- 31 sites in Georgia, Hungary and 4 more
- Volunteers
- 256 people
- Sponsor
- Merz Pharmaceuticals GmbH
Trauma, Neurologic Deficits
CT Change Management in Trauma Patients
In high-volume trauma centers, multi-slice CT scanners have become the routine imaging modality for screening trauma patients due to their speed and accuracy.
- Trial name
- NCT05138536
- Testing
- Pan-Computer Tomography
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Methodist Health System
Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases
Randomized Control Trials of Surgery for Pediatric OSA
Randomized study on pediatric OSA with 2 groups: mild-moderate OSA and severe OSA. Mild-moderate are randomized to either expectancy or ATE. Severe are randomized to either ATE or APP. Pediatric age span of 2 until 4,9 years.
- Conditions
- Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases, Pediatric Disorder
- Trial name
- NCT02315911
- Testing
- ATE, APP
- Where
- Sweden
- Volunteers
- 143 people
- Sponsor
- Karolinska University Hospital
Central Nervous System Disorder, Spine Disease
Neurological Surgery & Affiliated Services De-Identified Clinical Outcomes Database
The collection of data from the myriad of services described is significantly impacted by NIH guidelines defining medical research involving humans as well as the recent implementation of HIPAA constraints which further…
- Conditions
- Central Nervous System Disorder, Spine Disease, Peripheral Nerve Disorder
- Trial name
- MDAnalyze (NCT00593411)
- Where
- United States
- Volunteers
- 732 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Encephalopathy, Ischemic
End-of-life Intervention for African American Dementia Caregivers
In a community-based approach, the investigators long-term goal is to empower African American family caregivers who are designated healthcare proxies to make informed end-of-life treatment decisions for participants with…
- Trial name
- NCT03323411
- Testing
- Advance Care Treatment Plan
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Acute Coronary Syndrome
Variation Between Hospitals in Short-term Mortality After Acute Coronary Syndromes: A CALIBER Study
We seek to investigate whether hospitals in England and Wales vary in their rate of mortality following admission for heart attack or unstable angina, the extent of such variation, whether discharge diagnosis affects the extent…
- Trial name
- NCT01111071
- Where
- United Kingdom
- Volunteers
- 316,648 people
- Sponsor
- University College, London
Stroke
Balance Training After Stroke - a Randomized, Controled Pilot Study
This pilot study is part of a master's thesis. In the rehabilitation of stroke patients should be compared whether individual balance training has a greater effect than group balance training.
- Trial name
- NCT03791671
- Testing
- individual balance training, group balance training
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- RehaClinic AG
Brain and Central Nervous System Tumors, Leukemia
Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment
RATIONALE: Drugs used in chemotherapy, such as talotrexin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Leukemia, Lymphoma, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00458744
- Testing
- talotrexin, chemotherapy
- Sponsor
- Children's Oncology Group
Vertigo, Dizziness
Translation of Dizziness Handicap Inventory Scale Into Local Languages of Pakistan
The aim of the present study is to translate the Dizziness Handicap Inventory Scale into Urdu, Pashto, Punjabi, Sindhi and Balochi languages.
- Trial name
- NCT04849078
- Where
- Pakistan
- Volunteers
- 1,000 people
- Sponsor
- Riphah International University
Familial Amyloid Polyneuropathy (FAP)
Study of SOM0226 in Familial Amyloid Polyneuropathy
Clinical proof of concept study to evaluate SOM0226 efficacy in TTR Amyloidosis.
- Trial name
- NCT02191826
- Testing
- SOM0226
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- SOM Innovation Biotech SA
Cancer, Terminal Disease
Occupational Therapy Modulates the Pain in Cancer Patient Under Palliative Care
Pain is one of the most incapacitating symptoms because it is a complex experience that includes sensory and emotional perceptions, in which sensory, affective, cognitive, behavioral, cultural and social characteristics interact.
- Conditions
- Cancer, Terminal Disease, Pain
- Trial name
- NCT02102178
- Testing
- Tapestry, Regular occupation therapy, Weaving a scarf on a nail frame
- Volunteers
- 58 people
- Sponsor
- Barretos Cancer Hospital
Pain
The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery
The analgesic effect of dexamethasone is not well described, but studies have shown that dexamethasone can be a safe part of a multimodal analgesic strategy after surgery.
- Trial name
- NCT01953978
- Testing
- Dexamethasone, Morphine, Zofran
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sarcopenia
The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults
Aging is associated with a decline in muscle mass, strength, and physical function, leading to sarcopenia and frailty. This deterioration of muscle and physical capabilities impacts an individual's functional independence and…
- Trial name
- NCT06157385
- Testing
- Culinary Medicine, Control
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Major Depressive Disorder (MDD), Schizophenia Disorder
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for…
- Conditions
- Major Depressive Disorder (MDD), Schizophenia Disorder, Bipolar 1 Disorder, Alzheimer Disease
- Trial name
- Synapsing-SD (NCT07239843)
- Where
- Spain
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
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