Clinical trials: Disease Exacerbation
Chronic Obstructive Pulmonary Disease, Diastolic Dysfunction
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD
This is a prospective study to determine the relationships between pauci-inflammatory exacerbations and diastolic dysfunction, and their implications in hospitalized patients with acute exacerbations of COPD.
- Trial name
- NCT03110614
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Alabama at Birmingham
COPD Exacerbation
Prevalence, Associated Factors Points and Implementation of Care Procedures of Chronic Obstructive Pulmonary Disease Exacerbation in Healthcare Institution
Chronic Obstructive Pulmonary Disease (COPD) is a public health problem responsible for high mortality rate and significant costs for society.
- Trial name
- OPEDEXA (NCT05682404)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Schizophrenia, Schizoaffective Disorder
Prediction of Relapse in Schizophrenia/Schizoaffective Disorder With Smartphones and On-body Sensors
This study is dedicated to achieving a better understanding of how to identify patterns that indicate someone might be at high risk for relapse in schizophrenia or schizoaffective disorder.
- Trial name
- NCT02224430
- Testing
- schizophrenia/schizoaffective disorder.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Cystic Fibrosis
Early Intervention in Cystic Fibrosis Exacerbation
Individuals with cystic fibrosis (CF) develop chronic lung infections and suffer intermittent acute exacerbations of their lung disease.
- Trial name
- eICE (NCT01104402)
- Testing
- Home lung function and symptom monitoring
- Where
- 3 sites in United States
- Volunteers
- 267 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (COPD): The AURA Study (BY217/M2-124)
The aim of the study is to investigate the effect of roflumilast on exacerbation rate and pulmonary function in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00297102
- Testing
- Roflumilast
- Where
- 179 sites in United States, Australia and 9 more
- Volunteers
- 1,523 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Characteristics That Identify Exacerbation Risk Following Colds in COPD Patients
Respiratory virus infections are a common cause of COPD exacerbations and antiviral therapies have potential as treatments for exacerbations.
- Trial name
- NCT01376830
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation
The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- RECOPD (NCT01786928)
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo
COPD, COPD Exacerbation
Outgoing Lung Team - a Cross-sectorial Intervention in Patients With COPD
This study examines the effects of the work of an outgoing lung team in the Municipality of Aarhus, Denmark to patients with COPD (Chronic obstructive pulmonary disease) at risk of exacerbation of COPD.
- Trial name
- NCT04119856
- Testing
- Affiliation with the outgoing lung team
- Where
- Denmark
- Volunteers
- 144 people
- Sponsor
- University of Aarhus
Pulmonary Disease, Chronic Obstructive, Bronchospasm
Prophylactic Efficacy of Relenza Against Influenza A and B
In response to the European regulatory authorities, GSK is conducting a post-marketing observational study to assess the efficacy of Relenza when used as prophylaxis against influenza. SPECIFIC AIMS 1.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Bronchospasm, Influenza, Human, Asthma
- Trial name
- NCT01156701
- Testing
- Receiving a prescription of Relenza for prophylaxis, No prophylaxis with Relenza
- Volunteers
- 171,705 people
- Sponsor
- GlaxoSmithKline
Schizophrenia
A Study to Evaluate the Efficacy and Safety of ALKS 9072 (Also Known as Aripiprazole Lauroxil, ALKS 9070, or ARISTADA) in Subjects With Schizophrenia
The study will determine the efficacy of ALKS 9072 (also known as aripiprazole lauroxil or ALKS 9070) for the treatment of schizophrenia in subjects experiencing an acute exacerbation.
- Trial name
- NCT01469039
- Testing
- ALKS 9072
- Where
- 84 sites in United States, Bulgaria and 6 more
- Volunteers
- 623 people
- Sponsor
- Alkermes, Inc.
Chronic Obstructive Pulmonary Disease
PPSV23 Pneumococcal Vaccine in Chronic Obstructive Pulmonary Disease (COPD)
Streptococcus pneumoniae is the most common causes of community-acquired pneumonia and exacerbations in chronic obstructive pulmonary disease (COPD) patients, which are associated with morbidity, mortality, and higher health-care…
- Trial name
- NCT01381367
- Testing
- PPSV23 pneumococcal vaccine (Pneumovax®), Normal Saline
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- Far Eastern Memorial Hospital
Hepatitis B, Chronic
The Safety of Anti-viral Therapy in Preventing HBV MTCT in Pregnant Women After Discontinuation
Mother-to-child transmission (MTCT) is the most common mode of perpetuating chronic hepatitis B virus (HBV) infection in endemic countries.
- Trial name
- NCT03468907
- Testing
- Telbivudine 600mg, Tenofovir disoproxil fumarate 300mg
- Volunteers
- 111 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Asthma
Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Project Aim: To determine if intramuscular epinephrine is an effective adjunct to inhaled bronchodilators (β2 agonists) for children with severe asthma exacerbation.
- Trial name
- NCT01705964
- Testing
- IM epinephrine 1:1000, No intervention
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Louisville
COPD
Efficacy and Safety of AQX-1125 in Unstable COPD
The primary objective of this study is to evaluate the effect of 12 weeks of treatment with once daily administration of AQX-1125 compared to placebo in subjects following exacerbations of Chronic Obstructive Pulmonary Disease…
- Trial name
- FLAGSHIP (NCT01954628)
- Testing
- AQX-1125
- Where
- 8 sites in United States, Australia and 6 more
- Volunteers
- 400 people
- Sponsor
- Aquinox Pharmaceuticals (Canada) Inc.
Heart Failure; With Decompensation, Lower Extremity Edema
Above-Knee-High Application of Lower Limb Compression and Its Impact on Clinical Outcome in Patients Hospitalized With Heart Failure Exacerbation.
Heart failure (HF) remains one of the most common causes of hospitalization with high morbidity and mortality, and its worldwide prevalence is increasing.
- Conditions
- Heart Failure; With Decompensation, Lower Extremity Edema, Heart Failure，Congestive
- Trial name
- A-KHALIFE (NCT05467735)
- Testing
- Application of compression to bilateral lower extremities of patients using appropriately-sized elastic compression stockings.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Asthma Exacerbation, Emergency Department
Continuous Versus Intermittent Nebulization Therapy in Acute Asthma Exacerbation at Emergency Department
The goal of this clinical is to compare treatment outcomes between continuous nebulization and intermittent therapy in the management of acute exacerbation of asthma in the emergency department(ED).
- Conditions
- Asthma Exacerbation, Emergency Department, Nebulization
- Trial name
- NCT06291740
- Testing
- continuous nebulization, Intermittent nebulization
- Volunteers
- 40 people
- Sponsor
- Thammasat University
COPD Exacerbation Acute, Asthma Acute
Study on Acupuncture Treatment of Chronic Airway Diseases(Asthma and Chronic Obstructive Pulmonary Disease)
For patients in the acute phase of chronic airway diseases, on the basis of guideline-directed treatment, the experimental group was given acupuncture treatment, while the control group was given sham acupuncture treatment.
- Trial name
- NCT06869525
- Testing
- Acupuncture
- Volunteers
- 576 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Asthma
Trial of One Versus Two Doses of Dexamethasone for Pediatric Asthma Exacerbation
Comparing one versus two doses of oral dexamethasone for the treatment of asthma in the pediatric emergency department.
- Trial name
- R2D2 (NCT02725008)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Geoffrey W Jara-Almonte
Cystic Fibrosis (CF), Cystic Fibrosis Pulmonary Exacerbation
Understanding Inflammation, InFection and Interventions in Severe Exacerbations of Cystic Fibrosis
The UNIFIED-CF study is an observational study designed to investigate the impacts of treatment given for severe pulmonary exacerbations in people living with cystic fibrosis (pwCF).
- Trial name
- UNIFIED-CF (NCT07484607)
- Where
- 6 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Alexander Horsley
COPD, COPD Exacerbation
Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes (IbICEnCa)
We have demonstrated for the very first time that it is possible to isolate CPCs (circulating pulmonary cells) in patients with COPD in a sample of 17 patients (with a recovery rate of nearly 40%) and none of 10 healthy, non…
- Conditions
- COPD, COPD Exacerbation, COPD, Severe Early-Onset
- Trial name
- IbICEnCa (NCT03591978)
- Testing
- Isolation of Circulating Pulmonary Cells in peripheral blood
- Where
- 4 sites in Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
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