Clinical trials: Disease Risk Prediction
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
Graves' Orbitopathy, Thyroid Eye Disease, TED
Early Risk Stratification of Thyroid Eye Disease in Newly Diagnosed Graves' Disease
The aim of this observational study is to investigate why some people with newly diagnosed Graves' disease (GD) develop thyroid eye disease (TED), also known as Graves' orbitopathy, while others do not.
- Conditions
- Graves' Orbitopathy, Thyroid Eye Disease, TED, Graves' Disease
- Trial name
- SOGO (NCT07812194)
- Testing
- Study-related ophthalmological assessment and biospecimen collection, Blood biomarkers and standardized blood samples including thyroid function status
- Where
- Denmark
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cardiovascular Diseases, Cardiovascular Morbidity
Prediction of the Risks of Cardiovascular Mortality
Monitoring risks of cardiovascular diseases in working population (18 - 65 years old) by monitoring their BMI, ankle-brachial index with pulse wave velocity, cholesterol and glycemia.
- Conditions
- Cardiovascular Diseases, Cardiovascular Morbidity, Stroke, Embolism
- Trial name
- NCT06103448
- Testing
- Ankle-brachial index - system 100
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jan Evangelista Purkyne University
Cardiovascular Diseases
Development of CV Risk Prediction Tools Based on AI and Fundus Imaging Technology Study (PERFECT)
This study aims to develop a cardiovascular disease (CVD) screening tool and cardiovascular risk prediction tool based on fundus imaging data with the method of artificial intelligence.
- Trial name
- PERFECT (NCT06181552)
- Testing
- fundus photograpgy, optical coherence tomography, optical coherence tomography angiography
- Volunteers
- 1,072 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Prediction of High-risk Populations for Sarcopenia
Evaluation of a Sarcopenia Prediction Model and Development and Effectiveness of a Nursing Guidance Mobile App
We evaluated a model for the prediction of high-risk populations for sarcopenia in home settings, developed a sarcopenia nursing guidance mobile application, and assessed the effectiveness of this application in influencing…
- Trial name
- NCT05363033
- Testing
- sarcopenia nursing guidance mobile application was developed
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Healthy Volunteers
Communicating Multiple Disease Risks: A Translation of Risk Prediction Science
Epidemiology seeks to improve public health by identifying risk factors for cancer and other diseases and conveying that information to relevant audiences (e.g., physicians, the public).
- Trial name
- NCT03255291
- Testing
- Risk Assessment App, Audio Recording - Sleep, Surveys
- Where
- United States
- Volunteers
- 554 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
AKI - Acute Kidney Injury
Risk Factors and Deep Learning Model for CI-AKI
Contrast-associated acute kidney injury (CI-AKI) is a sudden and significant decline in renal function resulting from the use of a contrast agent.
- Trial name
- NCT06596785
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xiao Li，MD
Hypertension
A Cluster-Randomized Trial of a Hypertension Risk Model-Based Precision Intervention in High-Risk Adults in Shunyi District
This community cluster-randomized controlled trial aims to evaluate the effectiveness of a hypertension risk model-based precision intervention among adults at high risk of developing hypertension in Shunyi District, Beijing…
- Trial name
- NCT07804420
- Testing
- Hypertension Risk Model-Based Precision Intervention, Standard Health Education
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University
Delirium, Cognitive Impairment
Stanford ICU Delirium PIPRA Study
The purpose of this study is to determine the accuracy of the Pre-Interventional Preventive Risk Assessment (PIPRA) tool in predicting clinical cases of Intensive Care Units (ICU)-delirium, in a population at high risk of…
- Conditions
- Delirium, Cognitive Impairment, Delirium, Postoperative
- Trial name
- SIDPVS (NCT06519890)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Stanford University
Moyamoya Disease, Intracranial Hemorrhages
5T MRI and Metabolomics-Based Hemorrhage Risk Prediction in Moyamoya Disease
Intracranial hemorrhage is a leading cause of death and disability in patients with moyamoya disease (MMD), yet clinically available tools for predicting long-term hemorrhage risk are lacking.
- Conditions
- Moyamoya Disease, Intracranial Hemorrhages, Stroke
- Trial name
- NCT07781579
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Sepsis, Early Diagnosis
The Biomarker Prediction Model of Septic Risk in Infected Patients
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Sepsis is associated with high mortality because of the complex mechanisms.
- Conditions
- Sepsis, Early Diagnosis, Biomarkers
- Trial name
- NCT05095324
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- PRESAGE (NCT05640141)
- Testing
- MRI evaluation, Actimetry & IMU, Gait evaluation
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Burnout, Sleep Disturbance
Non-Invasive Sleep Monitoring for Burnout and Retention Risk in Postgraduate Nurses
Newly graduated nurses often experience high levels of psychological stress, sleep disturbance, fatigue, and burnout during the early transition into clinical practice.
- Conditions
- Burnout, Sleep Disturbance, Occupational Stress, Mental Health
- Trial name
- NCT07666633
- Testing
- Non-Invasive Sleep Monitoring
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Armed Forces General Hospital
Melanoma (Skin Cancer), Artificial Intelligence (AI)
Artificial Intelligence Based Melanoma Early Diagnosis and Risk Prediction in Children, Adolescents and Young Adults
The goal of this study is to develop supportive diagnostic artificial intelligence algorithms to distinguish melanoma from nevi or other benign pigmented skin lesions, especially in younger patients (below the age of 30).
- Conditions
- Melanoma (Skin Cancer), Artificial Intelligence (AI), Pediatric Cancer
- Trial name
- AI-MEL (NCT06621810)
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Pulmonary Embolism
Nudging Provider Adoption of Clinical Decision Support: Implementation of an EHR-Agnostic Pulmonary Embolism Risk Prediction Tool
The purpose of this study is to examine the impact of the nudge implementation strategy (CDS tool + Nudge) on adoption of guideline-concordant CT ordering for pulmonary embolism (PE) in 10 EDs.
- Trial name
- NCT07249385
- Testing
- Clinical Decision Support (CDS) tool with Nudges
- Where
- 3 sites in United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Gestational Diabetes
Early Prediction of Gestational Diabetes in High-risk Women Based on Breath Metabolomics
This study aim to develope novel breath markers of gestational diabetes through a prospective high-risk population cohort study and achieve early prediction of gestational diabetes based on an interpretable machine learning model.
- Trial name
- NCT06753734
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Tianjin Central Hospital of Gynecology Obstetrics
Hypertension
Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy
The MAPEC study was designed to investigate whether normalizing the circadian blood pressure profile towards a more dipper pattern (increasing the diurnal/nocturnal ratio of blood pressure) by the use of Chronotherapy (that is…
- Trial name
- MAPEC (NCT00295542)
- Testing
- Ambulatory blood pressure monitoring, Chronotherapy, timing of antihypertensive medication, ACEI (including spirapril, enalapril, quinapril, lisinopril)
- Where
- Spain
- Volunteers
- 3,344 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Breast Cancer, Lung Cancer
Predicting Cancer Risk With Digital and Molecular Markers
The goal of this study is to identify new markers to predict the risk of developing cancer, primarily breast cancer. For this purpose, researchers will compare data obtained from cancer patients and healthy individuals.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Gynecologic Cancer
- Trial name
- PräDigt (NCT06962670)
- Testing
- Biomaterial collection, BayPass mobile application
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Carotid Atherosclerosis
Carotid Risk Prediction (CRISP) Consortium
Develop adverse event prediction and plaque phenotype classification models for patients with known or suspected carotid artery disease.
- Trial name
- CRISP (NCT04448353)
- Testing
- vascuCAP
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Elucid Bioimaging Inc.