Clinical trials: Disease-Free Survival
Colorectal Cancer Stage III
The Prognosis Effect of Indocyanine Green (ICG) Fluorescence Guided Surgery on Disease-free Survival (DFS) of Stage III Colorectal Cancer
Previous studies of Indocyanine green (ICG) in colorectal surgery have focused on lymphatic mapping, lymph node detection, and the number of harvested lymph nodes.
- Trial name
- NCT06583564
- Testing
- ICG lymphangiography procedure
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Shanghai Tong Ren Hospital
Myeloma
Dasatinib in Combination With Melphalan and Prednisone to Treat Relapsed and Refractory Multiple Myeloma Patients
Clinically demonstrated efficacy of Melphalan and Prednisone in MM subjects as well as the confirmed inhibitory effect of dasatinib on several tyrosine kinase receptors and pathways implicated in the pathophysiology of MM.
- Trial name
- D-MP (NCT01116128)
- Testing
- dasatinib, melphalan, prednisone
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione EMN Italy Onlus
Non Small Cell Lung Cancer, Small-cell Lung Cancer
DIAGNOSIS, TREATMENT AND OUTCOME OF LUNG CANCER PATIENTS
Observational, prospective clinical research, multi-center clinical research platform with the main objective to assess molecular biomarker testing, treatment and outcome of patients with NSCLC or SCLC in Turkey
- Trial name
- REGISTURK-LUNG (NCT05254119)
- Where
- 39 sites in Turkey (Türkiye)
- Volunteers
- 6,000 people
- Sponsor
- Mahmut Gumus
Epithelial Ovarian Cancer, Ovarian Neoplasms
Centralization and Oncologic Outcomes in Ovarian Cancer
This is a multicenter, observational, retrospective and prospective study conducted within the REMO (Reggio Emilia - Modena) network in the Emilia-Romagna region (Italy), promoted by AUSL-IRCCS of Reggio Emilia.
- Conditions
- Epithelial Ovarian Cancer, Ovarian Neoplasms, Advanced Ovarian Cancer
- Trial name
- COOC - REMO (NCT07075939)
- Testing
- No Intervention: Observational Cohort
- Where
- 7 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Colorectal Neoplasms
The Predictive Value of Guangzhou Panel for Recurrence in Early-stage Colorectal Cancer
This study aims to evaluate the predictive value of a four-gene methylation assay called Guangzhou Panel in early-stage colorectal cancer. Patients will be divided into two groups: high risk group and low risk group.
- Trial name
- NCT03923335
- Testing
- DNA methylation detection
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Non-small Cell Lung Cancer, Progression, Disease
Energy for Lymphocytes
CERTIM is a cohort created in July 2015 to set up a multidisciplinary follow-up of cancer patients treated with immune checkpoint inhibitors.
- Trial name
- ELY (NCT04879316)
- Testing
- Resting Energy Expenditure measurement
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Hôpital Cochin
Stage II Colorectal Cancer, Stage III Colorectal Cancer
Thymosin-alpha 1 for Adjuvant Treatment After Radical Resection of High-risk Stage II and III Colorectal Cancer
For high-risk stage II and stage III colorectal cancer, even after radical resection and postoperative adjuvant chemo/radiotherapy, 30-40% of patients will still have recurrence and metastasis.
- Trial name
- NCT05086614
- Testing
- Thymosin Alpha1
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Fudan University
B-cell Acute Lymphoblastic Leukemia
A Study of Fludarabine Dosing in Children and Young Adults With B-cell Acute Lymphoblastic Leukemia
The researchers are doing this study to find out whether PK-targeted fludarabine is an effective Lymphodepletion (LD) chemotherapy approach for people with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) who will…
- Trial name
- NCT07223021
- Testing
- Fludarabine, Cyclophosphamide, CAR-T
- Where
- 6 sites in United States, Netherlands
- Volunteers
- 130 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Neuroendocrine Carcinoma, Digestive Cancer
Efficacy of Neoadjuvant Chemotherapy in Terms of DFS in Patients With Localized Digestive Neuroendocrine Carcinomas
NEONEC is a single-phase, phase II study evaluating the efficacy of the 12-month neoadjuvant chemotherapy in patients with locally differentiated digestive NEC.
- Trial name
- NEONEC (NCT04268121)
- Testing
- Neoadjuvant treatment, Adjuvant treatment
- Where
- 14 sites in France
- Volunteers
- 78 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Prostate Cancer Metastatic
Testing Radical Prostatectomy in Chinese Men With Prostate Cancer and oligoMetastases to the Bone
This study is to examine whether radical prostatectomy can impact survival and quality-of-life in men with oligo-metastatic prostate cancer.
- Trial name
- NCT03988686
- Testing
- Radical prostatectomy plus standard care, Standard of care for metastatic prostate cancer
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fudan University
Quality of Life, Cervical Cancer
Comprehensive Study on the Quality of Life in Cervical Cancer Patients
This is prospective cohort study. All the patients with primary cervical cancer in the future three years in Peking Union Medical College Hospital will be included in this study.
- Conditions
- Quality of Life, Cervical Cancer, Urodynamics, Rectum Dynamics
- Trial name
- NCT03967457
- Testing
- questionnaires survey, Urodynamic testing, Rectum dynamics testing
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Endocarditis
Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis
The purpose of the EARLY study is to evaluate the efficacy and effectiveness of early surgery in patients with Infective Endocarditis (IE).
- Trial name
- NCT03411499
- Testing
- Early surgery, Conventional therapy
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Maria Vittoria Hospital
Prostate Cancer
Prostate Specific Membrane Antigen (PMSA)-Based PET Imaging of High Risk Prostate Cancer
Background: People with prostate cancer usually have their cancer imaged with a CT scan and bone scan. They then have their prostate gland removed.
- Trial name
- NCT03976843
- Testing
- 18F-DCFPyL
- Where
- 6 sites in United States
- Volunteers
- 175 people
- Sponsor
- National Cancer Institute (NCI)
Locally Advanced Oral Squamous Cell Carcinoma, Locally Advanced Oropharyngeal Squamous Cell Carcinoma
Impact of Postoperative Radiotherapy Versus PD-1 Inhibitor Maintenance on Survival in Resectable Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma
Neoadjuvant immunochemotherapy (NAIC) has demonstrated promising pathological and survival outcomes in patients with resectable locally advanced oral and oropharyngeal squamous cell carcinoma (LA-OSCC/OPSCC).
- Trial name
- NCT07457099
- Testing
- Observation, Postoperative Radiotherapy, PD-1 Inhibitor Maintenance Therapy
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Zhujiang Hospital
Multiple Myeloma
VELCADE-Thalidomide-Dexamethasone (VTD) vs Thalidomide-Dexamethasone (TD) Incorporated Into Double Autotransplantation for Untreated Multiple Myeloma (MM)
Thalidomide-Dexamethasone (TD) is a standard induction therapy for Multiple Myeloma (MM). The present study is designed to compare TD with VELCADE-Thalidomide-Dexamethasone (VTD) as induction therapy in preparation for, and as…
- Trial name
- NCT01134484
- Testing
- Velcade, Thalidomide, Dexamethasone
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Michele Cavo
Locally Advanced Non Small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer
Local Ablative Stereotactic Radiotherapy for Residual Hypermetabolic Lesion in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Long-term Responders to Immunotherapy
At present, it is recommended to continue immunotherapy until progression or unacceptable toxicity. However, only a minority of patients benefits from a durable response and most see the disease progress despite several months of…
- Trial name
- TRAILOCLORI01 (NCT05111197)
- Testing
- SRT, Immunotherapy
- Where
- 5 sites in France
- Volunteers
- 112 people
- Sponsor
- Institut Cancerologie de l'Ouest
Carcinoma, Renal Cell
REGISTRY OF COMPLETE RESPONSES TO SUNITINIB IN SPANISH PATIENTS WITH METASTATIC RENAL CELL CARCINOMA
Observational, retrospective, multicentre study in spanish patients with metastatic Renal Cell Carcinoma (mRCC) treated with sunitinib as a first-line treatment (treatment with previous cytokine therapy is accepted) according to…
- Trial name
- ATILA (NCT03916458)
- Where
- 31 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Pfizer
Metastatic Colorectal Cancer (Mcrc), Intrahepatic Cholangiocarcinoma (Icc)
PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
Background: One way to treat liver cancer is to deliver chemotherapy drugs only to the liver (and not to the whole body). Researchers want to see if adding the drug PDS01ADC can improve the treatment.
- Conditions
- Metastatic Colorectal Cancer (Mcrc), Intrahepatic Cholangiocarcinoma (Icc), Intrahepatic Bile Duct Cancer, Colorectal Neoplasms
- Trial name
- NCT05286814
- Testing
- Dexamethasone, PDS01ADC, Intera 3000 Hepatic Artery Infusion Pump (HAIP)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Gastric Carcinoma
Apatinib Versus Placebo as a Third Line Treatment in Patients With Advanced or Metastatic Gastric Cancer
Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor receptor (VEGFR), and it's anti-angiogenesis effect has been viewed in preclinical tests.
- Trial name
- NCT00970138
- Testing
- apatinib tablet
- Where
- China
- Volunteers
- 141 people
- Sponsor
- Fudan University
Esophageal Squamous Cell Carcinoma (ESCC)
The Efficacy of Inflatable Mediastinoscopic-assisted Transhiatal Laparoscopic Esophagectomy
Abstract Background China has a high incidence of esophageal cancer, with surgery being the primary treatment modality. While the right thoracic approach for radical esophagectomy remains the standard surgical method, it is…
- Trial name
- NCT07581236
- Testing
- inflatable video-assisted mediastinoscopic transhiatal esophagectomy (IVMTE) combined with laparoscopy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-sen University