Clinical trials: Disinfection
Disinfection By-products
A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia
Appalachian Kentuckians in Martin and Letcher Counties are grappling with a health-threatening drinking water crisis arising from exposures to disinfection by-products (DBPs).
- Trial name
- NCT05172752
- Testing
- Citizen Scientist Training Program, Stakeholder Consultation Core Program
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Anna Hoover
Chronic Periodontitis
Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD)…
- Trial name
- NCT02316652
- Testing
- Scaling and root planing, Scaling and root planing with solution
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cross Infection
Randomized Pilot Study Evaluating Isopropyl Alcohol and UVC Rays in Disinfection of Cell Phones
Cell phones have become a fundamental accessory of our lives and clinical practice, often kept in contact with the body. Since most modern smartphones are equipped with touch screens, they can serve the function of reservoirs for…
- Trial name
- SaniPhone (NCT06194903)
- Testing
- isopropyl alcohol wipes, UVC box
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
This Study Will be Performed to Evaluate the Efficiency of 810 nm Diode Laser Disinfection on Periapical Healing in Root Canal Retreatment Cases
The Efficiency of 810 nm Diode Laser on Periapical Healing After Root Canal Retreatment
The main cause of endodontic disorders is microbial infection. From the infected root canal, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue through the apical foramen and…
- Trial name
- Retreatment (NCT07194837)
- Testing
- diode laser, Calcium Hydroxide (Ca(OH)2)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Liver Tumors
The Efficacy of Chlorhexidine Gluconate Pre - Disinfection Scrubbing in Preventing Surgical Site Infections for Hepatectomy Patients
To test whether pre - disinfection skin scrub with 4% chlorhexidine gluconate is more effective on the reduction of surgical site microbial colonization and subsequent infection than is normal saline.
- Trial name
- NCT01782573
- Testing
- Chlorhexidine gluconate, 0.9% Sodium Chloride
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Changhua Christian Hospital
Hand, Hygiene Practices and Knowledge
Effectiveness of VR on the Sustainability of Hand Hygiene Compliance: School-based RCT With 10-month Follow-up
This study aims to evaluate the effectiveness of a VR intervention on teaching handwashing skills which are promoted by the Centre for Health Protection, Department of Health, HKSAR.
- Trial name
- HKU-VR-2026 (NCT07659340)
- Testing
- VR Handwashing Game (2 sessions), VR Handwashing Game (1 session) + Video on hand hygiene (1 session)
- Where
- Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthcare Associated Infection, Clostridium Difficile Infection
Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection
The objective is to conduct a prospective, sham controlled, double-blinded, interventional crossover trial to compare standard terminal cleaning plus PX-UV (intervention) with standard terminal cleaning plus sham PX-UV (control)…
- Conditions
- Healthcare Associated Infection, Clostridium Difficile Infection, Infection Due to Multidrug Resistant Bacteria
- Trial name
- NCT03349268
- Testing
- Pulsed xenon ultraviolet (PX-UV) Device
- Where
- United States
- Volunteers
- 25,732 people
- Sponsor
- University of Michigan
Diarrhea
Solar Water Disinfection Intervention Trial in Bolivia
The importance of waterborne gastrointestinal illness throughout the developing world, the existence of a cheap and effective intervention (SODIS), the concurrent limited dissemination program for SODIS, the need for a controlled…
- Trial name
- SODIS_Bolivia (NCT00731497)
- Testing
- Solar Water Disinfection (SODIS)
- Where
- 2 sites in Bolivia
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Apical Periodontitis, Root Canal Infection
Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal
The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by…
- Trial name
- ENDOA (NCT06949176)
- Testing
- Root canal tratment using mecchanical and chemical preparation., Sodium Hypochlorite., Hydrogen peroxide.
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Periodontal Disease, Chronic Periodontitis
Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection
Evaluate and compare the effectiveness in a clinical and microbial perspective one stage full-mouth disinfection technique in relation to scaling and root planing per quadrant associated with chlorhexidine or azithromycin.
- Trial name
- NCT02126267
- Testing
- Scaling and root planing, Full mouth disinfection, Chlorhexidine gel and gluconate
- Where
- Brazil
- Volunteers
- 77 people
- Sponsor
- Centro Universitario de Lavras
Pain, Postoperative
Evaluation of Postoperative Pain With Eddy Tips (EPPET)
This investigation will focus on the use of EDDY tips, because it is known that the complete debridement of the canal is very difficult, which leads to an accumulation of tissue debris, bacteria and their products, resulting in…
- Trial name
- NCT03946306
- Testing
- 5,25% NaOCl with syringe needle irrigation alone, EDDY
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Universidade do Porto
Periprosthetic Joint Infections
Laser Disinfection in Periprosthetic Joint Infection
The eradication of biofilms from infected implants is still an unsolved challenge. The high-energy light beam of an Er:YAG laser causes rapid heating and explosive ablation of tissue.
- Trial name
- NCT06440564
- Testing
- Er:YAG Laser irradiation
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Post Operative Pain
Efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol
The ultimate biological aim of endodontic therapy is to either prevent or heal apical periodontitis. Root canal treatment can fail for various reasons, such as persistent infection, missing canals, ledges, canal transportation…
- Trial name
- NCT07800403
- Testing
- Novel Nanoparticle
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Minia University
Root Canal Infection, Periapical; Infection
Bacteria Elimination in Retreatment Cases Using Different Disinfection Techniques
Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.It has been stated that the one of the main cause of posttreatment…
- Trial name
- NCT03750162
- Testing
- VDW Ultra, AMD picasso, ProtaperNext X3 gutta-percha
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Perineal Infection, Maternal Infections Affecting Fetus or Newborn
Different Perineal Preparations Before Vaginal Birth to Maternal/Neonatal Infections and Cost Effectiveness
The vaginal microbiome plays a crucial role in women's health, primarily composed of beneficial bacteria such as Lactobacillus, which help maintain an acidic environment in the vagina, preventing the growth of pathogens.
- Conditions
- Perineal Infection, Maternal Infections Affecting Fetus or Newborn, Cost Effectiveness
- Trial name
- NCT06880445
- Testing
- Povidone-Iodine (PVP-I), Water
- Where
- Taiwan
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Tzu-Ying Huang
All Cause Mortality
Heat Disinfection of HD Water Treatment System in Hemodialysis Patients
Hemodialysis (HD) may lead to increase inflammatory response through a number of mechanisms. HD-related inflammation is mainly due to underlying kidney disease, coexisting comorbidities, uremia per se, dialyzer membrane…
- Trial name
- NCT01138280
- Testing
- CWP 103H (Gambro, Sweden): a heat disinfection device
- Where
- Taiwan
- Volunteers
- 540 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Catheter-related Bloodstream Infection
High-Flow Needleless Valve and DualCap Disinfection Devices Associate With Catheter-related Bloodstream Infection
The purpose of this study is to investigate whether the usage of High-Flow Needleless Valve and DualCap Disinfection Devices would reduce the incidence of catheter-related bloodstream infection in hemodialysis patients.
- Trial name
- NCT02990923
- Testing
- High-Flow Needleless Valve, DualCap Disinfection Devices
- Volunteers
- 102 people
- Sponsor
- Peking University First Hospital
Pain, Acute, Premature
Can Warm Skin Disinfection Reduce the Pain Peripheral Central Catheter Application in Premature Babies?
Peripheral central catheter application, especially in extremely low birth weight premature babies, is an intensive care follow-up procedure.
- Trial name
- w-pi (NCT04458441)
- Testing
- warm group/cold group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Surgical Site Infection
Impact of Postoperative Skin Disinfection With Chlorhexidine on Bacterial Colonization
A double-blinded, controlled study was conducted at one county hospital in Sweden. Patients were randomly assigned, skin samples were collected at four times; baseline, preoperative, after intervention and after 48 hours.
- Trial name
- NCT06114459
- Testing
- Sodium Chloride
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Linkoeping University
Water-Related Diseases
SAFEWATER Health & Behaviour Impact Field Trials; Colombia
At least 1.8 billion people globally use a source of drinking water that is faecally contaminated and thus likely to lead to diarrheal illness: nearly 1,000 children die each day due to water and sanitation-related diarrhoeal…
- Trial name
- SAFEWATER (NCT04829981)
- Testing
- SAFEWATER systems for drinking water disinfection, Behaviour change interventions
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster