Clinical trials: Disorder Heart
Heart Failure
Necklace-Shaped Sensor for Non-Invasive Monitoring of Stroke Volume and Cardiac Output
Study will compare measurements made with Necklace device for stroke volume/cardiac output with values from a FDA-approved reference device. The gold standard that will be used is Cardiac MRI.
- Trial name
- NCT02719301
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Mitral Valve Prolapse
Exercise Capacity Evaluation in Patients With Non-rheumatic Mitral Valve Prolapse (MVP)
Mitral valve prolapse (MVP) is a relatively common cardial problem in which one or more of the leaflets of the mitral valve prolapse during systole into the left atrium.
- Trial name
- NCT02499419
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Acute Coronary Syndromes
Revascularisation or Medical Therapy in Elderly Patients With Acute Anginal Syndromes
For octogenarian patients with NSTEMI (non-ST segment elevation myocardial infarction) an invasive-guided strategy will prove superior to a conservative strategy with respect to a combined endpoint of all cause mortality and…
- Trial name
- RINCAL (NCT02086019)
- Testing
- Conservative Arm, Invasive Arm
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Coronary Disease, Cardiovascular Diseases
Dietary Fatty Acids, PPAR Activated Genes, and CHD
To examine the relationship between genetic and dietary factors that modify the risk of coronary heart disease (CHD).
- Conditions
- Coronary Disease, Cardiovascular Diseases, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00071019
- Volunteers
- 4,547 people
- Sponsor
- Harvard School of Public Health (HSPH)
Acute Kidney Injury
A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)
The purpose of this study is to determine whether THR-184 when administered around the time of cardiac surgery that requires cardiopulmonary bypass can prevent or ameliorate the development of acute kidney injury.
- Trial name
- NCT01830920
- Testing
- THR-184
- Where
- 41 sites in United States, Canada
- Volunteers
- 452 people
- Sponsor
- Thrasos Innovation, Inc.
Heart Block, CIED Related Infection
Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation
Effect of single dose \& intrapocket prophylactic antibiotic to cardiac implantable electronic device-related infection \& biomarkers
- Conditions
- Heart Block, CIED Related Infection, CIED-related Infections, Antibiotic Prophylaxis
- Trial name
- BI-PACED (NCT06448624)
- Testing
- Ampicillin sulbactam 3 days
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Diponegoro
Coronary Disease, Cardiovascular Diseases
Epidemiology of Breast Arterial Calcification
To test the hypothesis that breast arterial calcification (BAC) seen on mammograms can identify women with an increased risk of coronary artery disease (CAD).
- Conditions
- Coronary Disease, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00091780
- Sponsor
- Mayo Clinic
Heart Failure With Reduced Ejection Fraction; Hypertension
Feasibility and Effectiveness of a Ring-Type Blood Pressure Device (CART-BP) Compared With 24-Hour Ambulatory Blood Pressure Monitoring in HFrEF
This study aims to evaluate the feasibility and diagnostic accuracy of the CART-BP ring-type wearable blood pressure monitoring device in comparison with 24-hour ambulatory blood pressure monitoring (ABPM) in patients with heart…
- Trial name
- RING-HFrEF (NCT07626879)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Keimyung University Dongsan Medical Center
Right Ventricular Function, Prone Position
Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay.
- Conditions
- Right Ventricular Function, Prone Position, Atelectasis, Atelectases, Postoperative Pulmonary
- Trial name
- BAROLO (NCT07632027)
- Testing
- Prone position
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Patent Foramen Ovale
Cardiox Shunt Detection Technology Study
The CARDIOX Flow Detection System is designed to detect the presence of indocyanine green (ICG) dye in the blood and is being investigated to establish its efficacy in detecting the presence of right to left cardiac shunt (RTLS).
- Trial name
- NCT01333761
- Testing
- Cardiox FDS
- Where
- 7 sites in United States
- Volunteers
- 71 people
- Sponsor
- Cardiox Corporation
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60…
- Conditions
- Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities
- Trial name
- CERBERUS (NCT06133842)
- Testing
- Intra-op EEG and CO data collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Out-of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
Improving Bystander CPR Quality Through Dispatcher-assisted Basic Life Support Education Program
In an attempt to enhance OHCA survival by increasing bystander CPR rate, this study will assess the effectiveness of the new basic life support with dispatch assistance (DA-BLS) education program through a simulation experiment.
- Trial name
- NCT02527473
- Testing
- Dispatcher-Assisted Basic Life Support CPR Education
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Obstructive Sleep Apnea, Hypertension
Assessment of Heart Rate Variability for Predicting Obstructive Sleep Apnea in Patients With Hypertension
This study aims to investigate the relationship between hypertension and obstructive sleep apnea (OSA) using heart rate variability (HRV) as a non-invasive biomarker of autonomic nervous system function.
- Trial name
- HRV-OSA-HTN (NCT07603583)
- Testing
- Polysomnography
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kaohsiung Armed Forces General Hospital
Pain (Knee), Pain and Anxiety
A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty
The goal of this clinical trial is to compare the effects of heart rate variability biofeedback (HRVB), mindfulness meditation, and psychological education in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain (Knee), Pain and Anxiety, TKA
- Trial name
- NCT07896954
- Testing
- Heart rate variability biofeedback, Mindfulness, psychoeducation
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Coronary Artery Disease
TDI Preejection Velocities and Myocardial Viability
The purpose of the study is to test accuracy of positive preejection velocity to predict left ventricular remodeling and long-term prognosis after revascularization in 200 patients with chronically dysfunctional myocardium.
- Trial name
- NCT00231205
- Testing
- Revascularization
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Charles University, Czech Republic
Heart Failure
Renal Denervation in Chronic Heart Failure
Renal denervation can be carried out for heart failure
- Trial name
- REACH (NCT02146794)
- Testing
- Renal denervation
- Volunteers
- 7 people
- Sponsor
- Imperial College London
Coronary Artery Disease
Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents
Prospective, multicenter, registry of at least 11,000 (and up to 15,000) consecutive patients with coronary artery disease undergoing stent-assisted percutaneous coronary intervention (PCI) using DES without major procedural…
- Trial name
- ADAPT-DES (NCT00638794)
- Testing
- Drug -Eluting Stent (Taxus™, Cypher®, Endeavor™, Xience V™)
- Where
- 8 sites in United States
- Volunteers
- 8,575 people
- Sponsor
- Cardiovascular Research Foundation, New York
Obstructive Sleep Apnea, Heart Failure
Mandibular Advancement Device for Treatment of Obstructive Sleep Apnea and Its Impact on Cardiac Remodeling
Primary aim: The MOSAIC trial aims to assess the impact of a mandibular advancement device (MAD) on Apnea-Hypopnea Index (AHI) in Asian patients with Heart Failure with reduced Ejection Fraction (HFrEF) and obstructive sleep…
- Trial name
- MOSAIC (NCT02948894)
- Testing
- Mandibular advancement device
- Where
- 2 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- National University of Singapore
Atrial Fibrillation
Autoimmunity in the Pathogenesis of AF
This research study is being done to find out whether autoimmune mechanisms are associated with the development of atrial fibrillation.
- Trial name
- NCT03498729
- Testing
- Peripheral Blood Sample
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Coronary Artery Disease
Comparison of Two Methods of Strain by Perioperative Transesophageal Echo in CABG : An Observational Study
There is an increasing need for diagnostic modalities able to objectively quantify myocardial function. Quantification of regional myocardial function with ultrasound is challenging on its own.
- Trial name
- Strain (NCT02692131)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
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