Clinical trials: Disorder of Aging
Inflammation, Malnutrition
Effects of Camelina Sativa Oil in Free-living Older Adults
The present study aims at evaluating the anti-inflammatory effects of a novel food in older adult volunteers. Briefly, this randomized, double-blind and placebo-controlled study is performed on 91 apparently healthy older adults…
- Conditions
- Inflammation, Malnutrition, Hyperglycemia, Dyslipidemias
- Trial name
- NCT04965948
- Testing
- Novel food snack
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Aging, Insulin Sensitivity
Antecedent Metabolic Health and Metformin Aging Study
Aging is the number one risk factor for the majority of chronic diseases. There are no pharmaceutical treatments to slow aging and prolong healthspan.
- Conditions
- Aging, Insulin Sensitivity, Chronic Disease, Mitochondria
- Trial name
- ANTHEM (NCT04264897)
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Sensorineural Hearing Loss
Efficacy of Digital Noise Reduction Strategies: A Hearing Aid Trial
The purpose of this study is to see if noise reduction programs in digital hearing aids help patients hear better than hearing aids without these programs.
- Trial name
- NCT00261768
- Testing
- Digital noise reduction
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- US Department of Veterans Affairs
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Healthy Ageing, Cognitive Decline
Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilities in Healthy Ageing.
This project investigates the relative benefits of regular physical activity and bilingualism for ameliorating cognitive decline in healthy ageing, with a particular focus on language function.
- Conditions
- Healthy Ageing, Cognitive Decline, Cardiorespiratory Fitness
- Trial name
- FAB (NCT07443189)
- Testing
- Home-Based HIIT
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Agder
Diabetes Mellitus Type 1, Healthy Ageing
FinnDiane LifeOne Study - Impact of Ageing on People With Type 1 Diabetes
Healthy aging refers to functional ability that enables well-being in older individuals. The focus thus shifts from chronological age to functional capacity and the individual's own experience of well-being.
- Trial name
- LifeOne (NCT07289204)
- Where
- Finland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Hearing Loss, Functional
The Effectiveness of Over the Counter Hearing Products for Middle-Aged Adults
The investigators will examine the effectiveness of selected over-the-counter personal sound amplifiers in addressing functional hearing problems in middle-aged listeners with mild hearing loss.
- Trial name
- NCT03511417
- Testing
- over-the-counter hearing device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
PARKINSON DISEASE (Disorder), Aged 65 Years or Older
Multidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease
With our study, the investigators aim to assess the impact of the fatigue experienced during daily life activities (tiredness) and whether there is a relationship with muscle fatigue during an exercise task.
- Trial name
- LifeLike (NCT07485218)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Mild Cognitive Impairment, Prediabetes
Piedmont Aging, Cognition & Exercise Study-2
The purpose of this research study is to examine the effects of high and low intensity exercise for those with mild memory loss and pre-diabetes.
- Trial name
- PACE-2 (NCT02312843)
- Testing
- Exercise/Aerobic, Exercise/Stretching
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Aging
The Eggs and actiVity in hEalth agiNg Pilot (EVEN-P) Trial in Older Persons
Two of the most effective lifestyle-based approaches to reduce the risk of adverse health events and enhance quality of life with aging are exercise and a healthy diet.
- Trial name
- EVEN-P (NCT04264013)
- Testing
- Exercise, Exercise plus diet (egg)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Ageing
Study to Assess the Effect of Leucine Along With Resistance Exercise on Muscle Strength and Quality of Life in Elders
The purpose of this study is to determine whether a nutritional supplement with an amino acid called leucine along with resistance exercise are effective in the improvement of muscle strength and quality of life in elderly people.
- Trial name
- NCT00929929
- Testing
- L-leucine., Maltodextrin., Exercise program.
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
COPD
Novel Predictors of Premature Aging in COPD Patients
•Examine whether COPD is associated with accelerated aging using a biological marker of aging and dermatological score
- Trial name
- NCT06019286
- Testing
- SCINEXA score
- Volunteers
- 100 people
- Sponsor
- Assiut University
Wellness Programs, Hospitalization
The Effectiveness of Peer-to-Peer Community Support to Promote Aging in Place
The investigators' overall objective is to evaluate the effectiveness of peer-to-peer support programs in preventing the necessity of acute health care and nursing home services for older adult populations and in promoting their…
- Conditions
- Wellness Programs, Hospitalization, Emergency Room
- Trial name
- NCT02308696
- Testing
- Peer-to-Peer Support, Standard Community Services
- Where
- 5 sites in United States
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes, Prediabetes
Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France - 3-year Follow-up
Populations in precarious situations or with low socio-economic status are at greater risk of diabetes and accelerated ageing. Depending on the population studied, the factors that may explain these health inequalities are not…
- Trial name
- PrévenDIAB 2 (NCT06866002)
- Testing
- Biological analysis, Physical examination and Questionnaires, Physical examination and Questionnaires
- Where
- France
- Volunteers
- 2,011 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Parkinson's Disease (PD), Healthy Aging
Exoskeleton-Assisted Mobility in Aging and in Parkinson's Disease
This study will evaluate whether a wearable robotic exoskeleton can improve mobility, balance, and walking in healthy older adults and in individuals living with Parkinson's disease, populations at high risk of falls and mobility…
- Trial name
- NCT07567482
- Testing
- Exoskeleton
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre intégré de santé et de services sociaux de l'Outaouais
Cardiovascular Diseases
Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical Function
The purpose of this study is to determine if treatment with a drug called fenofibrate, which is a PPAR-alpha agonist and controls how the heart metabolizes fats, will reverse the age-related decline in cardiac fat metabolism and…
- Trial name
- PPAR (NCT00627653)
- Testing
- fenofibrate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Anemia, Clonal Hematopoiesis
Aging of Hematopoietic Stem Cells - Molecular Architecture of Marrow Dysplasia and Clinical Contribution of Ineffective Hematopoiesis to Frailty in the Elderly
The prevalence and incidence of anemia tend to increase with advancing age. Relatively low hemoglobin concentrations are a common laboratory finding in the elderly, for the most part judged by physicians as a sign without…
- Trial name
- NCT03907553
- Testing
- targeted genome sequencing
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Aging, Undernutrition
Determination of In-vivo Plasma AA Appearance From Plant Protein Fibre Products
This study aims to assess the digestibility and efficacy of the study groups previously developed innovative plant-based protein and fibre products.
- Conditions
- Aging, Undernutrition, Appetite Loss, Age-Related Sarcopenia
- Trial name
- NCT05420142
- Testing
- Net peripheral AA appearance following ingestion of 3 selected PPF products compared to whey
- Where
- 2 sites in Ireland, Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Wrinkles, Ageing
Assessment of the Impact of a Coenzyme Q10 Supplementation on the Skin
Objective of the study is to determine the influence of dietary supplementation with coenzyme Q10 (CoQ10) on skin conditions. 33 healthy female subjects will be randomly assigned to a placebo group, a low-dose (LD) group…
- Conditions
- Wrinkles, Ageing, Photoprotection
- Trial name
- NCT02604641
- Testing
- Quvital LD group, Quvital HD group
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Deglutition Disorders
Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging
Oropharyngeal dysphagia (OD) is the most frequent digestive disorder in older people (>70 years) and has been recently recognized as a geriatric syndrome.
- Trial name
- NCT03050957
- Testing
- menthol
- Volunteers
- 38 people
- Sponsor
- Hospital de Mataró
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