Clinical trials: Disorder of Upper Respiratory System
Homogeneous Emphysema
Biologic Lung Volume Reduction (BLVR) Phase 2 Homogeneous Study
The purpose of the study is to evaluate the efficacy and safety of the 20 mL BLVR System in patients with homogeneous emphysema.
- Trial name
- NCT00630227
- Testing
- Biologic Lung Volume Reduction
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Aeris Therapeutics
Acute Rhinitis, Acute Pharyngitis
Efficacy and Safety of Jinhua Qinggan Granules (JHQG) for the Use of Acute Upper Respiratory Infection
The goal of this clinical trial is to learn if drug Jinhua Qinggan Granules (JHQG) works to treat acute upper respiratory tract infection in adults. It will also learn about the safety of drug JHQG.
- Conditions
- Acute Rhinitis, Acute Pharyngitis, Acute Tonsillitis, Acute Sinusitis
- Trial name
- (JHQG-AURI) (NCT07720583)
- Testing
- Jinhua Qinggan Granules
- Where
- Pakistan
- Volunteers
- 546 people
- Sponsor
- University of Karachi
Healthy Volunteers, Chronic Rhinosinusitis (Diagnosis)
Study of Probiotic Potential of Lactobacillus Strains in the Upper Respiratory Tract After Nasal Spray Application
Probiotics are defined as "live micro-organisms that, when administered in adequate amounts, confer a health benefit to the host" (Hill et al, 2014).
- Conditions
- Healthy Volunteers, Chronic Rhinosinusitis (Diagnosis), Probiotics, Sprays
- Trial name
- NCT03587545
- Testing
- Probiotic nasal spray
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Hypotension, Hypoxemia
Predictors of Clinically Relevant Hypotension and Hypoxemia During Propofol-Based Diagnostic Gastrointestinal Endoscopy
This prospective observational cohort study will evaluate the incidence and independent predictors of clinically relevant hypotension and hypoxemia during propofol-based diagnostic gastrointestinal endoscopy in adult patients at…
- Trial name
- PRO-GI SAFE (NCT07613073)
- Testing
- Propofol, Diagnostic gastrointestinal endoscopy
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- Bach Mai Hospital
Upper Respiratory Tract Infections
A Safety Study to Compare the Effect of Two PrEP-001 Nasal Powder Formulations on Nasal Mucosa and Serum Cytokine Production
A safety study to compare the effect of two different formulations of PrEP-001 nasal powder when dosed in healthy subjects
- Trial name
- NCT03198676
- Testing
- PrEP-001 6.4 mg, PrEP-001 3.2 mg
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prep Biopharm Limited
Upper Respiratory Tract Infection
Effect of eHealth on AB Use of Children With Acute, Uncomplicated URTIs
The goal of this clinical trial is to test the effectiveness of two self-care eHealth applications in parents of children with uncomplicated upper respiratory tract infections (URTIs).
- Trial name
- NCT06140446
- Testing
- FeverApp, DMT App
- Where
- Netherlands
- Volunteers
- 411 people
- Sponsor
- Max Nieuwdorp
Common Cold, Upper Respiratory Tract Infections
Hypertonic Saline Nasal Irrigation and Gargling for the Common Cold.
Viral upper respiratory tract infections (URTI), one of the commonest infection faced by humans, have a significant impact on individuals, families, health service and economy.
- Trial name
- ELVIS (NCT02438579)
- Testing
- Nasal Irrigation & Gargling
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- NHS Lothian
Cough, Superior Laryngeal Nerve Block
Efficacy of SLN Block for Chronic Cough
This is a research study to find out if superior laryngeal nerve blocks are an effective way to reduce cough when compared to placebo (a substance without any medical value).
- Conditions
- Cough, Superior Laryngeal Nerve Block, Neurogenic Cough
- Trial name
- NCT04421092
- Testing
- Superior laryngeal nerve block, Injection of steroid-lidocaine mixture
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Covid19, Corona Virus Infection
Safety, Tolerability and Pharmacokinetics of Inhaled Nanoparticle Formulation of Remdesivir (GS-5734) and NA-831
The clinical study is designed to evaluate the safety, tolerability and pharmacokinetics of inhaled nanoparticle nanoparticle formulation of Remdesivir (GS-5734) alone and in combination with NA-831 in 48 healthy volunteers.
- Conditions
- Covid19, Corona Virus Infection, Severe Acute Respiratory Syndrome, Severe Acute Respiratory Infection
- Trial name
- NEUROSIVIR (NCT04480333)
- Testing
- Drug: NA-831 - 0.10 mg/kg, Drug: NA-831 - 0.20 mg/kg, Drug: GS-5734 - 1.00 mg/kg
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Biomed Industries, Inc.
Coronavirus, Covid19
COVID-19: A Study to Evaluate Safety, Reactogenicity and Immunogenicity of the SARS-CoV-2 mRNA Vaccine CVnCoV in Adults With Co-morbidities
The primary objectives of this study are to evaluate the safety and reactogenicity profile after 1 and 2 dose administrations of investigational SARS-CoV-2 mRNA vaccine CVnCoV, and to evaluate the humoral immune responses 14 days…
- Conditions
- Coronavirus, Covid19, SARS-CoV-2, Severe Acute Respiratory Syndrome
- Trial name
- NCT04860258
- Testing
- CVnCoV Vaccine
- Where
- 4 sites in Belgium
- Volunteers
- 129 people
- Sponsor
- CureVac
Bronchiectasis
Comparison of Upper Extremity Exercise Capacity and ADL Between Subjects With Bronchiectasis and Healthy Controls
Bronchiectasis is a chronic lung disease characterized by permanent dilatation and destruction, resulting from the destruction of elastic tissue and muscular components in the bronchial walls, due to infection or inflammation.
- Trial name
- NCT05084547
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Nasal Obstruction, Exposure to Pollution
Rhinopharyngeal Retrograde Clearance is Effective to Adequate Upper Airways Function in Adults
Professionals working in polluted areas may present increased clinical airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and…
- Trial name
- NCT01976039
- Testing
- rhinopharyngeal retrograde clearance (RRC)
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Upper Respiratory Tract Infection, Bacterial Infection
Qingfei Granule for the Treatment of the Pediatric Acute Upper Respiratory Tract Infection With Bacterial Infection
The study aims to assess the antibacterial effect and symptoms-relief of Qingfei Granule in the patients with pediatric acute upper respiratory tract infection with bacterial infection.
- Conditions
- Upper Respiratory Tract Infection, Bacterial Infection, Chinese Medicine, Pediatric Acute Upper Respiratory Tract Infection
- Trial name
- NCT04479657
- Testing
- QingFei Granule, Cefuroxime
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhong Wang
SARS-CoV2 Infection
Clinical Study of the Third Dose Immunization Schedule of COVID-19 Inactivated Vaccine, (Vero Cells) in Adults Aged 18 Years and Above
To evaluate the immunogenicity and safety of the third dose SARS-CoV-2 Vaccine, Inactivated (Vero Cell) in adults aged 18 years and above, who inoculated the third dose after 3, 4, 5, or 6 months since finished two doses schedule…
- Trial name
- NCT05164731
- Testing
- SARS-CoV-2 Vaccine, Inactivated (Vero Cell)
- Where
- China
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Sleep Apnea, Obstructive
BAY2586116 Nasal Spray and OSA Severity
This investigator-initiated study aims to determine the effects of BAY2586116 (a novel TASK channel blocker nasal spray) on sleep apnoea severity and the potential influence of route of breathing.
- Trial name
- NCT05527457
- Testing
- BAY2586116
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Flinders University
COVID-19
Immunogenicity，Safety and Cross - Immune Response With Mutant Strains of a Third Dose of an Inactivated COVID-19 Vaccine
This is a phase Ⅳ follow-up clinical trial based on the previous Phase Ⅳ clinical trial of an inactivated COVID-19 vaccine (CoronaVac) manufactured by Sinovac Life Sciences Co., Ltd.The purpose of this study is to evaluate the…
- Trial name
- NCT05329038
- Testing
- Inactivated COVID-19 Vaccine
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Obstructive Sleep Apnea of Adult
Does Race Make a Difference in Obstructive Sleep Apnea?
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder, often associated with a compromised upper airway space and an increase in upper airway collapsibility.
- Trial name
- NCT03463785
- Testing
- cone beam computed tomography
- Where
- 2 sites in China, Netherlands
- Volunteers
- 58 people
- Sponsor
- Academic Centre for Dentistry in Amsterdam
Healthy Volunteers, Influenza
Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.
The study aims to evaluate an egg-based H5N8 influenza vaccine up to 3 dose levels (low, medium, and high dose) given with or without adjuvant to see if the adjuvant improves vaccine effectiveness.
- Trial name
- NCT07779408
- Testing
- Flu H5 egg pandemic low dose vaccine, with adjuvant, Flu H5 Egg Pandemic medium dose vaccine, with adjuvant, Flu H5 Egg Pandemic high dose vaccine, with adjuvant
- Where
- 16 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Sanofi
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
HA Residents With PVD, 6MWD Assessed at HA (2840m) vs LA (Sea Level)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT05996302
- Testing
- Relocation to sea level
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Sleep Apnea
Effects of Upper Airway Muscle Training on Obstructive Sleep Apnea Severity
The purpose of this study is to evaluate the effect of Asate Silent Sleep Training on obstructive sleep apnea (OSA) severity in patients with mild to moderate OSA.
- Trial name
- NCT04053153
- Testing
- Exercise equipment (a musical instrument that is based on the Medical Didgeridoo)
- Sponsor
- Stanford University