Clinical trials: Disorders of Gallbladder
Cholelithiasis
Lithotripsy for the Treatment of Gallstones
The purpose of this study is to determine the effectiveness and safety of using the Medstone lithotripter to treat single non-calcified gallstones from 4 to 20 mm in diameter.
- Trial name
- NCT00042549
- Testing
- Extracorporeal Shock Wave Lithotripsy, ursodiol
- Where
- 2 sites in United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Medstone International
Common Bile Duct Gallstones
Conventional Versus Rendezvous Technique of Intraoperative Endoscopic Retrograde Cholangiopancreatography
One of the new methods for management of common bile duct stones is intraoperative endoscopic sphincterotomy. It can be performed by many techniques.
- Trial name
- NCT01190332
- Testing
- endoscopic sphincterotomy by conventional method, endoscopic sphincterotomy by rendezvous method
- Where
- Egypt
- Volunteers
- 98 people
- Sponsor
- Mansoura University
Biliary Tract Cancer
XL119 Versus 5-Fluorouracil (5-FU) Plus Leucovorin (LV) in Subjects With Advanced Biliary Tumors
The main purpose of this study is to determine if XL119 is more effective than the combination of 5-fluorouracil (5FU) and leucovorin (LV) in prolonging the survival of subjects with advanced biliary tumors.
- Trial name
- NCT00090025
- Testing
- becatecarin, 5-Fluorouracil Plus Leucovorin
- Where
- 59 sites in United States, Belgium and 9 more
- Volunteers
- 248 people
- Sponsor
- Helsinn Healthcare SA
Ovarian Cancer, Cholecystolithiasis
Safety of Opportunistic Salpingectomy During Elective Laparoscopic Cholecystectomy.
The knowledge, coupled with epidemiological studies demonstrating lower ovarian cancer rates in women with a history of tubal sterilization has led to recommendations for opportunistic salpingectomy at the time of benign…
- Trial name
- NCT07642791
- Testing
- Opportunistic salpingectomy, Cholecystectomy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Acute Cholecystitis, Acute Cholecystitis With Obstruction
Patient Satisfaction After Ambulatory Emergency Laparoscopic Cholecystectomy
Acute cholecystitis is a common surgical emergency that, if left untreated, can result in significant morbidity and even death. It is characterized by inflammation of the gallbladder, usually caused by gallstones.
- Trial name
- NCT07616713
- Testing
- Laparoscopic Cholecystectomy
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Hospital General de Chihuahua - Dr. Salvador Zubirán Anchondo
Gallstones
Feasibility of Transvaginal Cholecystectomy
Today there are three different ways to remove a gallbladder with gallstones. Surgeons can remove the gallbladder through small incisions in the abdomen. This is called laparoscopic cholecystectomy. It is the current standard.
- Trial name
- TVC (NCT01232959)
- Testing
- Transvaginal Cholecystectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Cholecystitis
EUS-guided Gallbladder Drainage Instead of Laparoscopic Cholecystectomy for Acute Cholecystitis. A Feasibility Study.
To evaluate the feasibility of performing EGBD as a treatment of acute calculous cholecystitis in patients that are indicated for laparoscopic cholecystectomy.
- Trial name
- EGDB (NCT04197908)
- Testing
- EUS-guided gallbladder drainage (EGBD)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Fluorouracil, Cisplatin, and Radiation Therapy or Gemcitabine and Oxaliplatin in Treating Patients With Nonmetastatic Biliary Tract Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, cisplatin, oxaliplatin, and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer
- Trial name
- NCT00304135
- Testing
- cisplatin, gemcitabine hydrochloride, oxaliplatin
- Where
- 20 sites in France
- Volunteers
- 34 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Biliary Tract Cancer
Study of Hepatic Arterial Infusion to Treat Biliary Tract Carcinomas
This Phase II clinical trial is to study the effectiveness and safety of continuous hepatic arterial infusion (HAI) of Oxaliplatin and Fluorouracil in Patients with Unresectable Biliary tract carcinomas, and to explore a better…
- Trial name
- NCT01572324
- Testing
- Oxaliplatin, Fluorouracil, Leucovorin, Capecitabine
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Peking University
Biliary Tract Cancer (CCA), Intrahepatic Cholangiocarcinoma
Immunotherapy With Durva and Treme With or Without Capecitabine in Adjuvant Treatment for Biliary Tract Cancer
This is an interventional, prospective multicenter, open-label, phase II study in patients after curative surgery for BTC in a classic adjuvant situation, consisting of a two arm feasibility pilot part with a randomized…
- Conditions
- Biliary Tract Cancer (CCA), Intrahepatic Cholangiocarcinoma, Hilar Cholangiocarcinoma, Distal Cholangiocarcinoma
- Trial name
- NCT05239169
- Testing
- Durvalumab, Tremelimumab, Capecitabine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Cholecystitis, Perforated Duodenal Ulcer
Incentive Spirometry and Upper Abdominal Laparoscopic Surgery
To compare the effects of volume-oriented versus flow-oriented incentive spirometry on pulmonary function tests and functional capacity in patients of upper abdominal laparoscopic surgery.
- Conditions
- Cholecystitis, Perforated Duodenal Ulcer, Diaphragmatic Hernia, Benign Pancreas Tumor
- Trial name
- NCT04716166
- Testing
- Volume-oriented incentive spirometry, Flow-oriented incentive spirometry
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Cholecystitis, Acute, Common Bile Duct Calculi
Endoscopic Nasogallbladder Drainage Versus Gallbladder Stenting Before Cholecystecomy
Early laparoscopic cholecystectomy is the current standard therapy for acute cholecystitis, but temporary decompression of the gallbladder (GB) through percutaneous or endoscopic route can be required to alleviate inflammatory…
- Trial name
- NCT02394327
- Testing
- 7-Fr Pigtail type naso-cholecystic drainage tube (Liguory nasal biliary drainage set; Wilson-Cook Medical, Salem, NC, USA), 7-Fr double pigtail plastic stent (Zimmon; Wilson-Cook Medical, Salem, NC, USA)
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Ajou University School of Medicine
Cholecystolithiasis
Safety and Cost-effectiveness Study of Single Port Laparoscopic Cholecystectomies
Many feasibility studies have been published on Single Port surgery, but no comparative studies have shown any advantages compared to standard laparoscopy.
- Trial name
- SPoCOT (NCT00974194)
- Testing
- Single Trocar CCK, Standard CCK
- Where
- Switzerland
- Volunteers
- 268 people
- Sponsor
- University of Lausanne Hospitals
Biliary Tract Neoplasms, Cholangiocarcinoma
ABC-04 a Study of Cisplatin, Gemcitabine and Selumetinib in Patients With Advanced Biliary Tract Cancer
The objective of this study is to establish the recommended dose of selumetinib, a novel MEK inhibitor for use in combination with gemcitabine and cisplatin.
- Conditions
- Biliary Tract Neoplasms, Cholangiocarcinoma, Gallbladder Neoplasms
- Trial name
- ABC-04 (NCT01242605)
- Testing
- selumetinib, gemcitabine, cisplatin
- Where
- 3 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University College, London
Pancreatic Neoplasms Malignant, Malignant Neoplasm of Gall Bladder Non-resectable
Tomotherapy in Locally Advanced Gallbladder and Pancreatic Cancers
SUMMARY PROJECT TITLE: Concurrent chemo-radiation using Tomotherapy based IMRT in locally advanced Gallbladder and Pancreatic cancers: A Phase II study SPECIFIC OBJECTIVES: Primary To assess the radiological response by dose…
- Trial name
- NCT01118897
- Testing
- Tomotherapy
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Tata Memorial Hospital
Cholelithiasis, Cholecystitis, Acute
Evaluation of Risk Factors Leading to Conversion From Laparoscopic Cholecystectomy to Open Surgery
This retrospective controlled study aims to evaluate risk factors that affect open conversion in laparoscopic cholecystectomy. Patient characteristics, medical history, biochemical and radiological studies of the patient will…
- Conditions
- Cholelithiasis, Cholecystitis, Acute, Cholecystitis, Chronic, Gallbladder Diseases
- Trial name
- NCT06244589
- Testing
- Laparoscopic cholecystectomy, Open-conversion cholecystectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 1,695 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Cholecystitis, Acute
Usefulness of the CADISS® System for the Cleavage of Severe Adhesions in Cholecystectomy
Acute cholecystitis is the most common complication of cholelithiasis. Acute cholecystitis is inflammation of the gallbladder that develops over hours, usually due to an obstruction of the cystic duct by a gallstone.
- Trial name
- NCT05041686
- Testing
- CADISS® System
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- AuXin Surgery SA
Pancreatic Cancer, Cholangiocarcinoma
Association Between Cell-free Nucleic Acid in Blood, Urine and Microbiome in Stool With Pancreatobiliary Cancer
Based on the cell free nucleic acid analysis information of blood samples, the results of microbiome and metabolite analysis of stool and urine samples of pancreatic cancer and bile duct cancer patients, the clinical correlations…
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Gallbladder Cancer
- Trial name
- NCT05596370
- Testing
- cell free DNA in blood and urine, metabolite/microbiome in urine and stool
- Where
- 2 sites in South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cholecystolithiasis, Surgery
The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course
Uncomplicated laparoscopic cholecystectomy will in most patients result in moderate to severe pain until the first postoperative day. This will subside during the second and third postoperative day [1].
- Conditions
- Cholecystolithiasis, Surgery, Pain
- Trial name
- TRAVAKOL (NCT01552421)
- Testing
- TV NOTES cholecystectomy
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Abdominal Pain, Gallstone; Colic
RELIEF-pathway in Patients With Upper Abdominal Pain
Upper abdominal pain (UAP) is a common symptom and frequently the reason to visit the hospital. The prevalence of epigastric pain in the Dutch population is estimated to be as high as 37%.
- Conditions
- Abdominal Pain, Gallstone; Colic, Dyspepsia, Irritable Bowel Syndrome
- Trial name
- RELIEF (NCT06002516)
- Testing
- RELIEF-pathway
- Where
- Netherlands
- Volunteers
- 471 people
- Sponsor
- Radboud University Medical Center